Sequential methotrexate and fluorouracil for the treatment of node- negative breast cancer patients with estrogen receptor-negative tumors

Journal of Clinical Oncology

Volumn 14, Issue 7, 1996, Pages 1982-1992

  Fisher, B ^a   Dignam, J ^a   Mamounas, E P ^a   Costantino, J P ^a   Wickerham, D L ^a   Redmond, C ^a   Wolmark, N ^a   Dimitrov, N V ^a   Bowman, D M ^a   Glass, A G ^a   Atkins, J N ^a   Abramson, N ^a   Sutherland, C M ^a   Aron, B S ^a   Margolese, R G ^a  

^a National Surgical Adjuvant Breast   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; ESTROGEN RECEPTOR; FLUOROURACIL; METHOTREXATE;

ADULT; AGED; ALOPECIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; FEMALE; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; PRIORITY JOURNAL; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 8944231160     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1996.14.7.1982     Document Type: Article

References (18)

1. Fisher B, Redmond C, Dimitrov NV, et al: A randomized clinical trial evaluating sequential methotrexate and fluorouracil in the treatment of patients with node-negative breast cancer who have estrogen-receptor-negative tumors. N Engl J Med 320:473-478, 1989
2. Bonadonna G, Valagussa P, Tancini G, et al: Current status of Milan adjuvant chemotherapy trials for node-positive and node-negative breast cancer. NCI Monogr 1:45-49, 1986
3. Mansour EG, Gray R, Shatila AH, et al: Efficacy of adjuvant chemotherapy in high-risk node-negative breast cancer: An intergroup study. N Engl J Med 320:485-490, 1989
4. Fisher B, Fisher ER, Redmond C: Ten-year results from the NSABP clinical trial evaluating the use of L-phenylalanine mustard (L-PAM) in the management of primary breast cancer. J Clin Oncol 4:929-941, 1986
5. Fisher B, Redmond C, Brown A, et al: Treatment of primary breast cancer with chemotherapy and tamoxifen. N Engl J Med 305:1-6, 1981
6. Pocock SJ: Allocation of patients to treatments in clinical trials. Biometrics 35:183-197, 1979
7. Efron B: Forcing a sequential experiment to be balanced. Biometrika 58:403-417, 1972
8. Fisher B, Wolmark N, Fisher ER, et al: Lumpectomy and axillary dissection for breast cancer: Surgical, pathological and radiation considerations. World J Surg 9:692-698, 1985
9. Cutler SJ, Ederer F: Maximum utilization of the life-table method in analyzing survival. J Chronic Dis 8:699-712, 1958
10. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170, 1966
11. Byar D: Analysis of survival data in heterogeneous populations, in Barra JR, et al (eds): Recent Developments in Statistics. Amsterdam, the Netherlands, North-Holland, 1977, pp 51-68
12. Pepe MS, Mori M: Kaplan-Meier, marginal, or conditional probability curves in summarizing competing risks failure time data? Stat Med 12:737-751, 1993
13. Cox DR: Regression models and life tables. J R Stat Soc 34:187-220, 1972
14. Andersen PK: Testing goodness-of-fit of Cox's regression and life model. Biometrics 38:67-77, 1982
15. Shapiro CL, Gelman RS, Hayes DF, et al: Comparison of adjuvant chemotherapy with methotrexate and fluorouracil with and without cyclophosphamide in breast cancer patients with one to three positive axillary lymph nodes. J Natl Cancer Inst 85:812-817, 1993
16. Early Breast Cancer Trialists' Collaborative Group: Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy: 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Lancet 339:1-15, 71-85, 1992
17. Cobleigh MA, Tracy DM, Kleinman MB, et al: Methotrexate, 5-fluorouracil and leucovorin (M to F), with or without tamoxifen (tam), adjuvant chemotherapy for breast cancer: Effect on menstruation. Proc Am Soc Clin Oncol 12:73, 1993 (abstr)
18. Fisher B, Andersen S, Redmond C, et al: Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 333:1456-1461, 1995