The brain IGF system: Implications for Down syndrome

Developmental Brain Dysfunction

Volumn 9, Issue 2-3, 1996, Pages 85-92

  Sara, Vicki R ^a   Clayton, Kharen ^a   Cooke, Peter ^a   Craven, Cyril J ^a   Garcia Aragon, Juanita ^a   Hormon, Brian ^a   Harvey, Mark ^a   Haase, Helen ^a   Plenderleith, Mark ^a   Richardson, Neil ^a   Sherrard, Rachel ^a   Stahlbom, Par Axel ^a   Walker, Gillian ^a   Walsh, Terry P ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Brain; Down syndrome; IGF; Insulin like growth factors; Mental retardation; Neurodegeneration; Receptors

Indexed keywords

MESSENGER RNA; SOMATOMEDIN B; SOMATOMEDIN C;

ARTICLE; DOWN SYNDROME; HUMAN; MENTAL DEFICIENCY;

EID: 8944227507     PISSN: 10195815     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Sara VR, Hall K: Insulin-Like Growth Factors and Their Binding Proteins. Physiol Rev, 1990, vol 70, pp 591-614.
2. Sara VR, Lazarus L: The prenatal action of growth hormone on brain and Behavior. Nature 1974; 250:257-258.
3. Sara VR, Lazarus L, Stuart MC, King T: Fetal brain growth; selective action by growth hormone. Science 1974;185:446-447.
4. Sara VR, Carlsson-Skwirut C, Andersson C, Hall E, Sjögren B, Holmgren A, Jörnvall H: Characterisation of somatomedins from human fetal brain: Identification of a variant of insulin-like growth factor 1. Proc Natl Acad Sci USA 1986; 84:4904-4907.
5. Sandberg Nordqvist A-C, Ståhlbom P-A, Lake M, Sara VR: Characterization of two DNAs encoding insulin-like growth factor 1 (IGF 1) in the human fetus brain. Brain Res Mol Brain Res 1992;12:275-277.
6. Sara VR, Carlsson-Skwirut C, Drakenberg K, Giacobini MB, Håkansson L, Mirmiran M, Nord- berg A, Olson L, Reinecke M, Ståhlbom P-A, Sandberg Nordqvist A-C: The biological role of truncated insulin-like growth factor-1 and the tripeptide GPE in the central nervous'system. Ann NY Acad Sci 1993;692:183- 191.
7. Sara VR, Carlsson-Skwirut C, Bergman T, Jörnvall H, Roberts PJ, Crawford M, Nilsson-Häkansson L, Civalero I, Nordberg A: Identification of the truncated aminoterminal tripeptide of IGF-1, Gly-Pro-Glu (GPE), as a novel neuroactive peptide. Biochem Biophys Res Commun 1989; 165:766-771.
8. De Patger-Holthuizen P, Jansen M, Van der Kammen RA, Van Schaik FM A, Sussenbach JS: Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein. Biochim Biophys Acta 1988;950:282-295.
9. Bondy C, Werner H, Roberts CT Jr, Le Roith D: Cellular pattern of type-1 insulin-like growth factor receptor gene expression during maturation of the rat brain: Comparison with insulin-like growth factors I and II. Neuroscience 1992;46:909-923.
10. Ayer-Lelievre C, Ståhlbom P-A, Sara VR: Expression of IGF-1 and IGF-2 mRNA in the brain and cranio-facial region of the rat fetus. Development 1991;3:105-115.
11. Bondy CA, Werner H, Roberts CT Jr, Le Roith D: Cellular pattern of insulin-like growth factor-1 (IGF-1) and type 1 IGF receptor gene expression in early organogenesis: Comparison with IGF-II gene expression. Mol Endocrinol 1990;4:1386-1398.
12. Tseng LY-H, Brown AL, Yang YW-H, Romanus JA, Orlowski CC, Taylor T, Redder MM: The fetal rat binding protein for insulin-like growth factors is expressed in the choroid plexus and cerebrospinal fluid of adult rats. Mol Endocrinol 1989; 3:1559-1568.
13. Wood TL, Brown AL, Rechler MM, Pintar JE: The expression pattern of an insulin-like growth factor (IGF)-binding protein gene is distinct from IGF-II in the midgestational rat embryo. Mol Endocrinol 1990;4:1257-1263.
14. Adem A, Jossan SS, Argy R, Gillberg PG, Nordberg A, Winblad B, Sara VR: Insulin-like growth factor 1 (IGF-1) receptors in the human brain: Quantitative autoradiographic localization. Brain Res 1989;503:299-303.
15. Roghani M, Lassare C, Zapf J, Povoa G, Binoux M: Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins. J Clin Endocrinol Metab 1991;73:658-666.
16. Carlsson-Skwirut C, Jörnvall CH, Holmgren A, Anderson C, Bergman T, Lindqvist G, Sjögren B, Sara VR: Isolation and characterisation of variant IGF-1 as well as IGF-2 from adult human brain. FEBS Lett 1986;210:46-50.
17. Carlsson-Skwirut C, Lake M, Hartmanis M, Hall K, Sara VR: A comparison of the biological activities of recombinant intact and truncated insulin-like growth factor 1 (IGF-1). Biochim Biophys Acta 1989;1011:192-197.
18. Påhlman S, Meyerson G, Lindgren E, Schalling M, Johansson I: Insulin-like growth factor I shifts from promoting cell division to potentiating maturation during neuronal differentiation. Proc Natl Acad Sci USA 1991;88:9994-9998.
19. Giacobini M-B, Olson L, Sara VR: A truncated form of IGF-1 found in brain exerts trophic effects on fetal brain tissue grafts. Exp Neurol 1990;108:33-37.
20. McMorris FA, Smith TM, De Salvo S, Furlanetto RW: Insulin-like growth factor I/somatomedin C: A potent induces of oligodendrocyte development. Proc Natl Acad Sci USA 1986;83:822-826.
21. D'Ercole AJ: Expression of insulin-like growth factor-I in transgenic mice. Ann NY Acad Sci 1993;692:149-161.
22. Bourguignon JP, Gonzalez MLA, Gerard A, Franchimont P: Gondotropin releasing hormone inhibitory autofeedback by subproducts antagonist at N-methyl-d-aspartate receptors: A model of autocrine regulation of peptide secretion. Endocrinology 1994;134(3):1589-1592.
23. Bourguignon JP, Gerard A, Bonzalex M-LA, Franchimont P: Acute suppression of gonadotropin-releasing hormone secretion by insulin-like growth factor I and subproducts: An agedependent endocrine effect. Neuroendocrinology 1993;58:525-530.
24. Calissano P, Ciotti MT, Battistini L, Zone C, Angelini A, Merlo D, Mercanti D: Recombinant human insulin-like growth factor I exerts a trophic action and confers glutamate sensitivity on glutamate-resistant cerebellar granule cells. Proc Natl Acad Sci USA 1993;90:8752-8756.
25. Nilsson-Håkansson L, Civalero I, Zhang X, Carlsson-Skwirut C, Sara VR, Nordberg A: Effects of IGF-1, truncated IGF-1 and the tripeptide Gly-Pro-Glu on acetylcholine release from parietal cortex of rat brain. Neuropharm Neurotox 1993; 4:1111-1114.
26. Komoly S, Hudson LD, Webster HD, Bondy C: Insulin-growth factor I gene expression is induced in astrocytes during experimental demyelination. Proc Natl Acad Sci USA 1992;89:1894-1898.
27. Lee W-H, Clemens JA, Bondy CA: Insulin-like growth factors in the response to cerebral ischaemia. Mol Cell Neurosci 1992;3:36-43.
28. Gluckman P, Klempt N, Guan J, Mallard C, Sirimanne E, Dragunow M, Klempt M, Singh K, Williams C, Nikolics K: A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischaemic injury. Biochem Biophys Res Commun 1992;182:593-599.
29. Tham A, Nordberg A, Grissom FE, Carlsson-Skwirut C, Vitanen M, Sara VR: Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type. J Neural Transm Gen Sect 1993;5:165-176.
30. Adem A, Ekblom J, Gillberg PG, Jossan SS, Hoog A, Winblad B, Aquilonius S-M, Wang L-H, Sara V: Insulin-like growth factor-1 receptors in human spinal cord: Changes in amyotrophic lateral sclerosis. J Neural Transm Gen Sect 1994;97:73-84.
31. Sara VR, Hall K, Rodeck CH, Wetterberg L: Human embryonic somatomedin. Proc Natl Acad Sci USA 1981;78:3175-3179.
32. Sara VR, Gustavson K-H, Annerén G, Hall K, Wetterberg L: Somatomedins in Down's syndrome. Biol Psychiatry 1983;18:803-811.
33. Annerén G, Sara VR, Hall K, Tuvemo T: Growth and somatomedin responses to growth hormone in Down's syndrome. Arch Dis Child 1986;61:48-52.
34. Annerén G, Gustafsson J, Sara VR, Tuvemo T: Normalized growth velocity in children with Down's syndrome during growth hormone therapy. Intell Disabil Res 1993;37:381-387.
35. Annerén G, Carlsson-Skwirut C, Sara VR, Tuvemo T, Gustafsson J: The effects of growth hormone therapy on growth and mental development in children with Down syndrome. Dev Brain Dysfunct 1996;9:138-143.
36. Lobie PE, Garcia-Aragon J, Lincoln DT, Barnard R, Wilcox JN, Waters MJ: Localization and ontogeny of growth hormone receptor gene expression in the central nervous system. Brain Res Dev Brain Res 1993;74:225-233.