A neuroprotective derivative of erythropoietin that is not erythropoietic

Expert Opinion on Investigational Drugs

Volumn 13, Issue 11, 2004, Pages 1517-1519

  Doggrell, Sheila A ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Doggrell Biomedical Communications   (New Zealand)

Author keywords

Animal models of neurotoxicity; CEPO; EPO; Ischaemic stroke; Neuroprotection

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN DERIVATIVE; ERYTHROPOIETIN RECEPTOR; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ARTICLE; BLOOD BRAIN BARRIER; CARBAMOYLATION; CEREBROVASCULAR ACCIDENT; DIABETIC NEUROPATHY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSE REGIMEN; DRUG HALF LIFE; DRUG MECHANISM; DRUG PENETRATION; DRUG RECEPTOR BINDING; ERYTHROPOIESIS; HUMAN; IN VIVO STUDY; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE COMPRESSION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; SCIATIC NERVE; SPINAL CORD DISEASE;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; HUMANS; MICE; NEUROPROTECTIVE AGENTS; RATS;

EID: 8844285169     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.13.11.1517     Document Type: Article

References (5)

1. LEIST M, GHEZZI P, GRASSO G et al.: Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science (2004) 305:239-242.
2. SASAKI R: Pleiotropic functions of erythropoietin. Intern. Med. (2003) 42:142-149.
3. BIACHI R, BUYUKAKILLI B, BRINES M et al.: Erythropoietin both protects from and reverses experimental diabetic neuropathy. Proc. Natl. Acad. Sci. USA (2004) 101:823-828.
4. SIREN A-L, FRATELLI M, BRINES M et al.: Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl. Acad. Sci. USA (2001) 98:4044-4049.
5. ERBAYRAKTAR S, GRASSO G, SFACTERIA A et al.: Asialoerythropoieten is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc. Natl. Acad. Sci. USA (2003) 100:6741-6746.