A novel candidate region for ALS on chromosome 14q11.2

Neurology

Volumn 63, Issue 10, 2004, Pages 1936-1938

  Greenway, Matthew J ^a,f   Alexander, M D ^a   Ennis, S ^c   Traynor, B J ^c,d   Corr, B ^b   Frost, E ^e   Green, A ^c   Hardiman, O ^a,b  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b BEAUMONT HOSPITAL   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d MassGeneral Institute for Neurodegenerative Disease   (United States)

^e Irish Motor Neuron Dis Association   (Ireland)

^f OUR LADY S CHILDREN S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIN; VASCULOTROPIN;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CHROMOSOME 14Q; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC LINKAGE; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; ONSET AGE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS;

EID: 8844263662     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000144344.39103.F6     Document Type: Article

References (10)

1. Hayward C, Colville S, Swingler RJ, Brock DJ. Molecular genetic analysis of the APEX nuclease gene in amyotrophic lateral sclerosis. Neurology 1999;52:1899-1901.
2. Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Incidence and prevalence of ALS in Ireland, 1995-1997: a population-based study. Neurology 1999;52:504-509.
3. Distler JH, Hirth A, Kurowska-Stolarska M, Gay RE, Gay S, Distler O. Angiogenic and angiostatic factors in the molecular control of angiogenesis. Q J Nucl Med 2003;47:149-161.
4. Weiner HL, Weiner LH, Swain JL. Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Science 1987;237:280-282.
5. Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001;28:131-138.
6. Lambrechts D, Storkebaum E, Morimoto M, et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 2003;34:383-394.
7. Strydom DJ, Fett JW, Lobb RR, et al. Amino acid sequence of human tumor derived angiogenin. Biochemistry 1985;24:5486-5494.
8. Tomkins J, Dempster S, Banner SJ, Cookson MR, Shaw PJ. Screening of AP endonuclease as a candidate gene for amyotrophic lateral sclerosis (ALS). Neuroreport 2000;11:1695-1697.
9. Hallahan TW, Shapiro R, Vallee BL. Dual site model for the organogenic activity of angiogenin. Proc Natl Acad Sci USA 1991;88:2222-2226.
10. Shapiro R, Fox EA, Riordan JF. Role of lysines in human angiogenin: chemical modification and site-directed mutagenesis. Biochemistry 1989;28:1726-1732.