The GSTT1 deletion polymorphism is associated with initial response to glucocorticoids in childhood acute lymphoblastic leukemia [8]

Leukemia

Volumn 18, Issue 11, 2004, Pages 1920-1923

  Meissner, B ^a   Stanulla, Martin ^a   Ludwig, W D ^b   Harbott, J ^c   Moricke A ^a   Welte, K ^a   Schrappe, M ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Section of Pathology   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; DAUNORUBICIN; GLUCOCORTICOID; GLUTATHIONE TRANSFERASE; METHOTREXATE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER REGRESSION; CHILD; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; GENE DELETION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEMOGLOBIN DETERMINATION; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; IMMUNOPHENOTYPING; LETTER; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 8844260372     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403521     Document Type: Letter

References (8)

1. Schrappe M, Reiter A, Zimmermann M, Harbott J, Ludwig WD, Henze G et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Munster. Leukemia 2000; 14: 2205-2222.
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3. Listowsky I. High capacity binding by glutathione S-transferases and glucocorticoid resistance. In: Tew KD, Pickett CB, Mantle TJ, Mannervik B, Hayes JD (eds). Structure and Function of Glutathione Transferases. Boca Raton, FL: CRC Press, 1993, pp 199-209.
4. Anderer G, Schrappe M, Müller-Brechlin A, Lauten M, Muti P, Welte K et al. Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia. Pharmacogenetics 2000; 10: 715-726.
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6. Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM et al. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 1994; 300: 271-276.
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8. Sprenger R, Schlagenhaufer R, Kerb R, Bruhn C, Brockmoeller J, Roots I et al. Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation. Pharmacogenetics 2000; 10: 557-565.