Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors

Carcinogenesis

Volumn 25, Issue 11, 2004, Pages 2101-2105

  Nishikawa, Manabu ^a   Chang, Bao Jun ^a   Inoue, Masayasu ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; ENZYME KINETICS; GROWTH RATE; IN VIVO STUDY; INOCULATION; MOUSE; MOUSE STRAIN; NONHUMAN; PERITONEAL CAVITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SOLID TUMOR; SUBCUTANEOUS TISSUE; WILD TYPE;

ANIMALS; CARCINOMA, EHRLICH TUMOR; CELL DIVISION; DNA FRAGMENTATION; KINETICS; MICE; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE II; PERITONEAL NEOPLASMS;

EID: 8844252998     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgh218     Document Type: Article

References (22)

1. Nathan,C. (1992) Nitric oxide as a secretary product of mammalian cells. FASEB J., 6, 3051-3064.
2. Bredt,D.S. and Snyder,S.H. (1992) Nitric oxide, a novel neuronal messenger. Neuron, 8, 3-11.
3. Moncada,S., Palmer,R.M.J. and Higgs,E.A. (1991) Nitric oxide: physiology, pathology, and pharmacology. Pharmacol. Rev., 43, 109-142.
4. Nishikawa,M., Sato,E., Kashiba,M., Kuroki,T., Utsumi,K. and Inoue,M. (1998) Macrophage-derived nitric oxide induces apoptosis of rat hepatoma cells in vivo. Hepatology, 28, 1474-1480.
5. Nishikawa,M., Sato,E.F., Utsumi,K. and Inoue,M. (1996) Oxygen-dependent regulation of energy metabolism in ascites tumor cells by nitric oxide. Cancer Res., 56, 4535-4540.
6. Dembinska-Kiec,A., Dulak,J., Partyka,L., Huk,I. and Maitnski,T. (1997) VEGF-nitric oxide reciprocal regulation. Nature Med., 11, 1177.
7. Kennovin,G.D., Hirst,D.G., Stratford,M.R.L. and Flitney,F.W. (1994) In Moncada,S., Feelisch,M., Busse,R. and Higgs,E.A. (eds) The Biology of Nitric Oxide. Portland Press, London, pp, 259-263.
8. Laubach,V.E., Shesely,E.G., Smithies,O. and Sherman,P.A. (1995) Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl Acad. Sci. USA, 92 10688-10692.
9. 15N]nitrate in biological fluids. Anal. Biochem., 126, 131-138.
10. Olivotto,M. and Paoletti,F. (1981) The role of respiration in tumor cell transition from the noncycling to the cycling state. J. Cell. Physiol., 107, 243-249.
11. Liu,X., Kim,C.N., Yang,J., Jemmerson,R. and Wang,X. (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86, 147-57.
12. 2+ in toxic cell killing. Trends Pharmacol., 10, 281-285.
13. Jenkins,D.C., Charles,I.G, Thomsen,L.L., Moss,D.W., Holmens,L.S., Baylis,S.A., Rhodes,P., Westmore,K., Emson,P.C. and Moncada,S. (1995) Roles of nitric oxide in tumor growth. Proc. Natl Acad. Sci. USA, 92, 4392-4396.
14. Maeda,H., Matsumura,Y. and Kato,H. (1988) Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer. J. Biol. Chem., 263, 16051-16054.
15. Keller,R., Geiges,M. and Keist,R. (1990) L-Arginine-dependent reactive nitrogen intermediates as mediators of tumor cell killing by activated macrophages. Cancer Res., 50, 1421-1425.
16. Andrade,S.P., Hart,I.R. and Piper,P.J. (1992) Inhibitors of nitric oxide synthase selectively reduce flow in tumor-associated neovasculature. Br. J. Pharmacol., 107, 1092-1095.
17. Jenkins,D.C., Charles,I.G., Thomsen,L.L., Moss,D.W., Holmes,L.S., Baylis,S.A., Rhodes,P., Westmore,K., Emson,P.C. and Moncada,S. (1995) Roles of nitric oxide in tumor growth. Proc. Natl Acad. Sci. USA, 92, 4392-4396.
18. Thomsen,L.L., Miles,D.W., Happerfield,L., Bobrow,L.G., Knowles,R.G. and Moncada,S. (1995) Nitric oxide synthase activity in human breast cancer. Br. J. Cancer, 72, 41-44.
19. Senger,D.R., Galli,S.J., Dvorak,A.M., Perruzzi,C.A., Harvey,V.S. and Dvorak,H.F. (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science, 219, 983-985.
20. Ziche,M., Morbidelli,L., Choudhuri,R., Zhang,H.T., Donnini,S., Granger,H.J. and Bicknell,R. (1997) Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Invest. 99, 2625-2634.
21. Zhang,H.T., Scott,P.A., Morbidelli,L., Peak,S., Moore,J., Turley,H., Harris,A.L., Ziche,M. and Bicknell,R. (2000) The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo. Br. J. Cancer, 83, 63-68.
22. Tisdale,M.J. (1991) Cancer cachexia. Br. J. Cancer, 63, 337-342.