Base-catalyzed deuterium and tritium labelling of 1-biphenyl-4-ylpropane-1, 2-dione and deuteration of aryl methyl ketones

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 47, Issue 12, 2004, Pages 891-894

  Berthelette, Carl ^a   Scheigetz, John ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Aryl methyl ketone; Base catalyzed exchange; Diketone; Labelled compounds; Tritium

Indexed keywords

CATALYSIS; DEUTERIUM; KETONES;

ARYL METHYL KETONE; BASE CATALYZED; BASE-CATALYZED EXCHANGE; DEUTERATIONS; DIKETONES; EXCHANGE REACTION; LABELED COMPOUND; LABELINGS; METHYL GROUP; METHYL KETONES;

TRITIUM;

1 BIPHENYL 4 YLPROPANE 1,2 DIONE; BASE; DEUTERIUM; DIKETONE; KETONE; METHYL GROUP; RADIOPHARMACEUTICAL AGENT; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CATALYST; CHEMICAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME KINETICS; ISOTOPE LABELING; MASS SPECTROMETRY; RADIOACTIVITY;

TRITIUM;

EID: 8844226674     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.879     Document Type: Article

References (9)

1. (a) Warkentin J, Lam LKM. Can J Chem 1964; 42: 1676.
2. (b) Barraclough P, Young DW. Tetrahedron Lett 1970; 11: 2293.
3. (c) Peng CT, Buchman O. Tetrahedron Lett 1985; 26: 1375.
4. (d) Coller BAW, Roy Jackson W, Stragalinou A, Strauss JUG. Tetrahedron Lett 1979; 20: 2261.
5. (e) Kabalka GW, Pagni RM, Bridwell P, Walsh E, Hassaneen HM. J Org Chem 1981; 46: 1513.
6. (a) Borodina GM, Lyubchanskaya VM, Kraft MYa. Zh Org Khim 1967; 3: 2216.
7. (b) Bunnett JF, Sundberg JE. Chem Pharm Bull 1975; 23: 2620.
8. Nahm S, Weinreb SM. Tetrahedron Lett 1981; 22: 3815.
9. Bonadies F, Bonini C. Synth Commun 1988; 18: 1573.