Targets for Alzheimer's disease: Lessons learnt from flies

Drug Discovery Today: TARGETS

Volumn 3, Issue 2, 2004, Pages 64-70

  Konsolaki, M ^a   Cohen, D ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Alzheimer's Disease; beta amyloid; disease pathways; Drosophila; Drug Discovery; genetic analysis; Genetics; Molecular Medicine; Neurobiology; Pharmaceutical Science

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; CHOLESTEROL; GAMMA SECRETASE; KINESIN; MEVINOLIN; NICASTRIN; POLYGLUTAMINE; PRESENILIN 1; TAU PROTEIN;

ALZHEIMER DISEASE; CHOLESTEROL SYNTHESIS; DROSOPHILA; ENZYME ACTIVITY; GENE IDENTIFICATION; GENE MUTATION; GENETIC LINKAGE; LIGHT CHAIN; MOLECULAR CLONING; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; REVIEW; SENILE PLAQUE; SIGNAL TRANSDUCTION; TRANSGENE;

EID: 8844226196     PISSN: 17418372     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1741-8372(04)02395-3     Document Type: Review

References (65)

1. Drachman D.A. Preventing and treating Alzheimer's disease: strategies and prospects. Expert Rev. Neurotherapeutics. 3:2003;565-569
2. Walsh D.M., et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416:2002;535-539
3. Luo L., et al. Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor. J. Neurosci. 10:1990;3849-3861
4. Torroja L., et al. APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons. J. Neurosci. 16:1996;4638-4650
5. Coulson E.J., et al. What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochem. Int. 36:2000;175-184
6. Wasco W., et al. Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc. Natl. Acad. Sci. U. S. A. 89:1992;10758-10762
7. Wasco W., et al. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat. Genet. 5:1993;95-100
8. Zheng H., et al. beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell. 81:1995;525-531
9. Luo L., et al. Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron. 9:1992;595-605
10. Torroja L., et al. The Drosophila β-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J. Neurosci. 19:1999;7793-7803
11. Allinquant B., et al. Amyloid precursor protein in cortical neurons: coexistence of two pools differentially distributed in axons and dendrites and association with cytoskeleton. J. Neurosci. 14:1994;6842-6854
12. Nitsch R.M., et al. Regulation of proteolytic processing of the amyloid beta-protein precursor of Alzheimer's disease in transfected cell lines and in brain slices. J. Neural Transm. Suppl. 44:1994;21-27
13. Fossgreen A., et al. Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype. Proc. Natl. Acad. Sci. U. S. A. 95:1998;13703-13708
14. Yagi Y., et al. Overexpression of human amyloid precursor protein in Drosophila. Mol. Cell Biol. Res. Commun. 4:2000;43-49
15. Torroja L., et al. Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr. Biol. 9:1999;489-492
16. Gunawardena S., Goldstein L.S. Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron. 32:2001;389-401
17. Kamal A., et al. Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron. 28:2000;449-459
18. Kamal A., et al. Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP. Nature. 414:2001;643-648
19. Mattson M.P. A multi-talented secreted protein. Trends Neurosci. 24:2001;441-442
20. Vassar R. The β-secretase, BACE: a prime drug target for Alzheimer's disease. J. Mol. Neurosci. 17:2001;157-170
21. Struhl G., Greenwald E. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature. 398:1999;522-525
22. Ye Y., et al. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 398:1999;525-529
23. Wolfe M.S., et al. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity. Nature. 398:1999;513-517
24. De Strooper B., et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:1999;518-522
25. Cao X., Sudhof T.C. A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 293:2001;115-120
26. Duilio A., et al. A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases. Nucleic Acids Res. 19:1991;5269-5274
27. McLoughlin D.M., Miller C.C. The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. FEBS Lett. 397:1996;197-200
28. Guo Y., et al. Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling. J. Neurosci. 19:1999;8435-8442
29. Selkoe D., Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu. Rev. Neurosci. 26:2003;565-597
30. Yu G., et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature. 407:2000;48-54
31. Chung H.M., Struhl G. Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila. Nat. Cell Biol. 3:2001;1129-1132
32. Francis R., et al. aph-1 and pen-2 are required for Notch pathway signaling, γ-secretase cleavage of βAPP, and presenilin protein accumulation. Dev. Cell. 3:2002;85-97
33. Takasugi N., et al. The role of presenilin cofactors in the γ-secretase complex. Nature. 422:2003;438-441
34. Jackson G.R., et al. Polyglutamine-expanded human Huntington transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 21:1998;633-642
35. Warrick J.M., et al. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. Cell. 93:1998;939-949
36. Kazemi-Esfarjani P., Benzer S. Genetic suppression of polyglutamine toxicity in Drosophila. Science. 287:2000;1837-1840
37. Fernandez-Funez P., et al. Identification of genes that modify ataxin-1-induced neurodegeneration. Nature. 408:2000;101-106
38. Steffan J.S., et al. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 413:2001;739-743
39. Auluck P.K., et al. Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease. Science. 295:2002;865-868
40. Konsolaki M., et al. Genetic studies of AD-related genes in Drosophila melanogaster. Neurobiol. Aging. 23:2002;S238-S239
41. Delacourte, A. (2001) Neurofibrillary degeneration: patterns of tau isoform expression. In: Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics (Iqbal, K. et al., eds), pp. 587-607, John Wiley & Sons
42. Goedert M.R., et al. Tau mutations cause frontotemporal dementias. Neuron. 21:1998;955-958
43. Lewis J., et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 293:2001;1487-1491
44. Lewis J., et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat. Genet. 25:2000;402-405
45. Heidary G., Fortini M.E. Identification and characterization of the Drosophila tau homolog. Mech. Dev. 108:2001;171-178
46. Wittmann C.W., et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science. 293:2001;711-714
47. Jackson G.R., et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron. 34:2002;509-519
48. Giles R.H., et al. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim. Biophys. Acta. 1653:2003;1-24
49. Cedazo-Minguez A., Cowburn R.F. Apolipoprotein E: a major piece in the Alzheimer's disease puzzle. J. Cell. Mol. Med. 5:2001;254-266
50. Refolo L.M., et al. A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8:2001;890-899
51. Petanceska S.S., et al. Statin therapy for Alzheimer's disease: will it work? J. Mol. Neurosci. 19:2002;155-161
52. Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572
53. Frears E.R., et al. The role of cholesterol in the biosynthesis of β-amyloid. Neuroreport. 10:1999;1699-1705
54. Wolozin B., et al. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57:2000;1439-1443
55. Deak P., et al. P element insertion alleles of essential genes on the third chromosome of Drosophila melanogaster: correlation of physical and cytogenetic maps in chromosomal region 86E-87F. Genetics. 147:1997;1697-1722
56. Winder W.W., Hardie D.G. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am. J. Physiol. 277:1999;E1-10
57. Tschape J.A., et al. The neurodegeneration mutant lochrig interferes with cholesterol homeostasis and Appl processing. EMBO J. 21:2002;6367-6376
58. Fonte V., et al. Interaction of intracellular beta amyloid peptide with chaperone proteins. Proc. Natl. Acad. Sci. U. S. A. 99:2002;9439-9444
59. Kraemer B.C., et al. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc. Natl. Acad. Sci. U. S. A. 100:2003;9980-9985
60. Clemens J.C., et al. Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl. Acad. Sci. U. S. A. 97:2000;6499-6503
61. Boutros M., et al. Genome-wide RNAi screens to dissect signaling pathways in Drosophila. Europ. Dros. Res. Conf. 18:2003;B03
62. Kiger A.A., et al. A functional genomic analysis of cell morphology using RNA interference. J. Biol. 2:2003;27-41
63. Giot L., et al. A protein interaction map of Drosophila melanogaster. Science. 302:2003;1727-1736
64. Ye Y., Fortini M.E. Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster. J. Cell Biol. 146:1999;1351-1364
65. Hu Y., Fortini M.E. Different cofactor activities in γ-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex. J. Cell Biol. 161:2003;685-690