Efficacy and tolerability of hypericum extract STW 3-VI in patients with moderate depression: A double-blind, randomized, placebo-controlled clinical trial

Advances in Therapy

Volumn 21, Issue 4, 2004, Pages 265-275

  Uebelhack, Ralf ^a   Gruenwald, Joerg ^b,c   Graubaum, Hans Joachim ^b   Busch, Regina ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b Phytopharm Research   (Germany)

^c PhytoPharm Consulting   (Germany)

Author keywords

Hamilton Depression Scale; Hypericum perforatum; St. John's wort; Von Zerssen Adjective Mood Scale

Indexed keywords

GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN; HYPERICUM EXTRACT;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GASTROINTESTINAL DISEASE; HAMILTON SCALE; HEARTBURN; HEMOGLOBIN DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; SIDE EFFECT; TREATMENT OUTCOME;

EID: 8744306967     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02850158     Document Type: Article

References (19)

1. Judd L. Mood disorders in the general population represent an important and worldwide public health problem. Int Clin Psychopharmacol. 1995;10(suppl 4)5-10.
2. Bilia AK, Gallori S, Vincieri FF. St. John's wort and depression: efficacy, safety and tolerability - an update. Life Sci. 2002;70:3077-3096.
3. Laakmann G, Schüle C, Baghai T, Kieser M. St. John's wort in mild to moderate depression: the relevance of hyperforin for the clinical efficacy. Pharmacopsychiat. 1998;31(suppl):54-59.
4. Kalb R, Trautmann-Sponsel RD, Kieser M. Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. Pharmacopsyciat. 2001;34:96-103.
5. Laakmann G, Jahn G, Schüle C. Hypericum-perforatum-Extrakt bei der Behandlung leichter bis mittelschwerer Depressionen: Klinische und pharmakologische Aspekte. Nervenarzt. 2002;73: 600-612.
6. Hippius H. St. John's wort (Hypericum perforatum): a herbal antdipressant. Curr Med Res Opin. 1998;14:171-184.
7. Müller WE, Rolli M, Schäfer C, Hafner U. Effects of Hypericum Extract (LI 160) in Biochemical Models of Antidepressant Activity. Pharmacopsychiat. 1997;30(suppl):102-107.
8. Uebelhack R, Franke L. In vitro effects of St. John's Wort Extract and hyperforin on 5HT uptake and efflux in human blood platelets. Pharmacopsychiatry. 2001;34(suppl 1):S146-S147.
9. Schrader E, Meier B, Brettström A. Hypericum treatment of mild-moderate depression in a placebo-controlled study: a prospective, double-blind, randomized, placebo-controlled, multicentre study. Human Psychopharmacol. 1998;13:163-169.
10. Hänsgen KD, Vesper J. Antidepressive Wirksamkeit eines hochdosierten Hypericum-Extraktes. Münch Med Wschr. 1996;138:29-33.
11. Vorbach EU, Hübner WD, Arnold KH. Wirksamkeit und Verträglichkeit des Hypericum-Extraktes LI 160 im Vergleich mit Imipramin. Nervenheilkunde. 1993;12:290-296.
12. Philipp M, Kohen R Hiller KO. Hypericum extract versus imipramine or placebo in patients with moderate depression: randomized multicentre study of treatment for eight weeks. BMJ. 1999;319:1534-1538.
13. Linde K, Ramirez G, Mulrow D, Pauls A, Weidenhammer W, Melchart D. St. John's wort for depression. An overview and meta-analysis of randomized clinical trials. BMJ. 1996;313:253-258.
14. Schulz V. Clinical trials with Hypericum extracts in patients with depression:results, comparisons, conclusions for therapy with antidepressant drugs. Phytomedicine. 2002;9:468-474.
15. Volz HP. Controlled clinical trials of hypericum extracts in depressed patients. An overview. Pharmacopsychiat. 1997;30(suppl 2):72-76.
16. Gaster B, Holroyd J. St. John's Wort for Depression. A Systematic Review. Arch Intern Med. 2000; 160:152-156.
17. Brockmöller J, Reum T, Bauer S, Kerb R, Hübner WH, Roots J. Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans. Pharmacopsychiat. 1997;30(suppl): 94-101.
18. Hänsgen KD, Vesper J, Ploch M. Multizentrische Doppelblindstudie zur antidepressiven Wirksamkeit des Hypericum-Extraktes LI 160. Nervenheilkunde. 1993;12:285-289.
19. Sommer H. Besserung psychovegetativer Beschwerden durch Hypericum im Rahmen einer multizentrischen Doppelblindstudie. Nervenheilkunde. 1991;10:308-310.