"Statistics" is not a sausage machine: A statistician's viewpoint and some comments on experimental design

Alternatives to Laboratory Animals

Volumn 32, Issue SUPPL. 2, 2004, Pages 5-8

  Gaines Das, Rose E ^a  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Communication; Experimental design; Randomisation; Replication

Indexed keywords

ANIMAL EXPERIMENT; CONFERENCE PAPER; COOPERATION; EXPERIMENTAL ANIMAL WELFARE; EXPERIMENTAL DESIGN; INFORMATION PROCESSING; INTERPERSONAL COMMUNICATION; PRIORITY JOURNAL; RANDOMIZATION; RESEARCH ETHICS; SCIENCE; STATISTICS; TEAMWORK;

ANIMALIA;

EID: 8744306242     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290403202s03     Document Type: Conference Paper

References (13)

1. Cotes, P.M., Bartlett, W.A., Gaines Das, R.E., Flecknell, P. & Termeer, R. (1980). Dose regimens of human growth hormone: effects of continuous infusion and of a-gelatin vehicle on growth in rats and rate of absorption in rabbits. Journal of Endocrinology 87, 303-312.
2. MacIntyre, I., Hillyard, C.J., Murphy, P.K., Reynolds, J.J., Gaines Das, R.E. & Craig, R.K. (1982). A second plasma calcium-lowering peptide from the human calcitonin precursor. Nature, London 300, 460-462.
3. Deacon, R., Hellebostad, M., Gaines Das, R.E., Milne, A., Rowley, M. & Cotes, P.M. (1993). Invalidity from nonparallelism in a radioimmunoassay for erythropoietin accounted for by human serum antibodies to rabbit IgG. Experimental Hematology 21, 1680-1685.
4. Xing, D., Gaines Das, R., Newland, P. & Corbel, M. (2002). Comparison of the bioactivity of reference preparations for assaying Bordetella pertussis toxin activity in vaccines by the histamine sensitisation and Chinese hamster ovary-cell tests: assessment of validity of expression of activity in terms of protein concentration. Vaccine 20, 3535-3542.
5. Storring, P.L., Gaines Das, R.E., Mulders, J.W.M. & Halder, M. (2002). Physicochemical methods for predicting the biological potency of recombinant follicle stimulating hormone: an international collaborative study of isoelectric focusing and capillary zone electrophoresis. Biologicals 30, 217-234.
6. Festing, M.F.W., Overend, P., Gaines Das, R., Cortina Borja, M. & Berdoy, M. (2002). The Design of Animal Experiments: Reducing the Use of Animals in Research Through Better Experimental Design, 112pp. London, UK: Royal Society of Medicine Press.
7. Rao, C.R. (1992). R.A. Fisher: the founder of modern statistics. Statistical Science 7, 34-48.
8. Fisher, R.A. (1931). Principles of plot experimentation in relation to the statistical interpretation of the results. Rothamsted Conference 3, 11-13.
9. Miles, A.A. (1951). Biological standards and the measurement of therapeutic activity. British Medical Bulletin 7, 283-291.
10. Storring, P.L. & Gaines Das, R.E. (2001). The fourth International Standard for Human Urinary FSH and LH: specificities of LH seminal vesicle weight gain assays in the collaborative study differ between laboratories. Journal of Endocrinology 171, 119-129.
11. Gaines Das, R.E. (2002). Role of ancillary variables in the design, analysis, and interpretation of animal experiments. ILAR Journal 43, 214-222.
12. Finney, D.J. (1970). Discussion. In Statistics in Endocrinology (ed. J.W. McArthur & T. Colton), p. 25. Cambridge, MA, USA: MIT Press.
13. Marriott, F.H.C. (1974). The Interpretation of Multiple Observations, 117pp. London, UK: Academic Press.