Severe gemcitabine-induced capillary-leak Syndrome mimicking cardiac failure in a patient with advanced pancreatic cancer and high-risk cardiovascular disease

Clinical Oncology

Volumn 16, Issue 8, 2004, Pages 577-579

  Biswas, S ^a   Nik, S ^a   Corrie, Pippa G ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Capillary leak syndrome; Corticosteroids; Gemcitabine; Pancreatic adenocarcinoma; Pulmonary toxicity

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GEMCITABINE; HYDROCORTISONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METFORMIN; PREDNISOLONE;

ABDOMEN; ADULT; ARTICLE; CAPILLARY LEAK SYNDROME; CARCINOMATOSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CASE REPORT; CENTRAL VENOUS PRESSURE; CORONARY ARTERY ATHEROSCLEROSIS; DIABETES MELLITUS; DISEASE SEVERITY; EDEMA; HEART ARRHYTHMIA; HEART FAILURE; HEART INFARCTION; HIGH RISK PATIENT; HUMAN; HYPERCHOLESTEROLEMIA; LEUKOCYTE DIFFERENTIAL COUNT; LEUKOCYTOSIS; LUNG EDEMA; LUNG TOXICITY; LYMPHANGITIS; MALE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; RESPIRATORY DISTRESS; RESPIRATORY FAILURE; SEPSIS;

ADENOCARCINOMA; ANTIMETABOLITES, ANTINEOPLASTIC; CAPILLARY LEAK SYNDROME; CORONARY ARTERIOSCLEROSIS; DEOXYCYTIDINE; DIAGNOSIS, DIFFERENTIAL; HEART FAILURE, CONGESTIVE; HUMANS; MALE; MIDDLE AGED; PANCREATIC NEOPLASMS; PULMONARY EDEMA;

EID: 8744303684     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2004.06.019     Document Type: Article

References (7)

1. T. De Pas G. Curigliano L. Franceschelli C. Catania L. Spaggiari F. de Braud Gemcitabine-induced systemic capillary leak syndrome Ann Oncol 12 2001 1651-1652
2. P. Corrie V.J. Spanswick R. Sehmbi et al. Increased persistence of treosulfan-induced DNA interstrand crosslinks when combined with gemcitabine: Proof of principle of a phase I trial Proc Am Soc Clin Oncol 22 2004 128a
3. K. Pulkkanen V. Kataja R. Johansson Systemic capillary leak syndrome resulting from gemcitabine treatment in renal cell carcinoma: A case report J Chemother 15 2003 287-289
4. P.M. Boiselle M.M. Morrin M.S. Huberman Gemcitabine pulmonary toxicity: CT features J Comput Assist Tomogr 24 2000 977-980
5. N.J. Vander Els V. Millar Successful treatment of gemcitabine toxicity with a brief course of oral corticosteroid therapy Chest 114 1998 1779-1781
6. N. Pavlakis D.R. Bell M.J. Millward J.A. Levi Fatal pulmonary toxicity resulting from treatment with gemcitabine Cancer 80 1997 286-291
7. S. Hosoe K. Komuta K. Shibata et al. Gemcitabine and vinorelbine followed by docetaxel in patients with advanced non-small-cell lung cancer: A multi-institutional phase II trial of nonplatinum sequential triplet combination chemotherapy (JMTO LC00-02) Br J Cancer 88 2003 342-347