Effects of 1,3-butadiene, isoprene, and their photochemical degradation products on human lung cells

Environmental Health Perspectives

Volumn 112, Issue 15, 2004, Pages 1488-1495

  Doyle, Melanie ^a   Sexton, Kenneth G ^a   Jeffries, Harvey ^a   Bridge, Kevin ^a   Jaspers, Ilona ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

1,3 butadiene; Air pollution; Atmospheric chemistry; Hydrocarbons; In vitro; Interleukin 8; Irradiative chambers; Isoprene; Lung epithelial cells; Photochemical products

Indexed keywords

1,3 BUTADIENE; ACETALDEHYDE; ACROLEIN; FORMALDEHYDE; HYDROCARBON; INTERLEUKIN 8; ISOPRENE; KETONE DERIVATIVE; NITRIC OXIDE;

AIR POLLUTION; ARTICLE; CELL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; GAS CHROMATOGRAPHY; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS CELL; MASS SPECTROMETRY; PHOTOCHEMISTRY; PRIORITY JOURNAL; TOXICITY TESTING;

BUTADIENES; CARCINOGENS; CELL CULTURE TECHNIQUES; GENE EXPRESSION REGULATION; HEMITERPENES; HUMANS; INFLAMMATION; INTERLEUKIN-8; LUNG; PENTANES; PHOTOCHEMISTRY; PLANTS;

EID: 8744283767     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.7022     Document Type: Article

References (54)

1. Alarie Y, Schaper M, Nielson GD, Abraham MH. 1998. Structure-activity relationships of volatile organic chemicals as sensory irritants. Arch Toxicol 72:125-140.
2. Atkinson R. 1990. Gas-phase tropospheric chemistry of organic compounds: a review. Atmos Environ 24A:1-41.
3. Atkinson R, Arey J. 2003. Gas phase tropospheric chemistry of biogenic volatile organic compounds: a review. Atmos Environ 37(suppl 2):S197-S219.
4. 3 with isoprene. Res Chem Intermed 20(3/4/5):385-394.
5. Biesenthal TA, Wu Q, Shepson PB, Wiebe HA, Anlauf KG, Mackay GI. 1997. A study of relationships between isoprene, its oxidation products, and ozone, in the lower Fraser Valley, BC. Atmos Environ 31(14):2049-2058.
6. Carter WPL. 1996. Condensed atmospheric photooxidation mechanisms for isoprene. Atmos Environ 30(24):4275-4290.
7. Chien C-J, Jeffries HE, Charles JM, Sexton KG. 1997. Analysis of airborne carboxylic acids and phenols as their pentafluorobenzyl derivatives in the oxidation products of isoprene and toluene. In: Measurement of Toxic and Related Air Pollutants: Proceedings of a Specialty Conference April 29-1 May 1997, Research Triangle Park, NC, Vol 2 (Air and Waste Management Association and U.S. Environmental Protection Agency's National Exposure Research Laboratory, eds). Pittsburgh:Air & Waste Management Association, 803-816.
8. Claeys M, Graham B, Vas G, Wang W, Vermeylen R, Pashynska V, et al. 2004. Formation of secondary organic aerosols through photooxidation of isoprene. Science 303:1173-1176.
9. Clean Air Act Amendments of 1990. 1990. Public Law 101-549.
10. Cunningham ML, Price HC, O'Connor RW, Moorman MP, Mahler JF, Nold JB, et al. 2001. Inhalation toxicity studies ofthe alpha,beta-unsaturated ketones: 2-cyclohexene-1-one. Inhal Toxicol 13(1):25-36.
11. Dasgupta PK, Dong S, Hwang H, Yang HC, Genfa Z. 1988. Continuous liquid-phase fluorometry coupled to a diffusion scrubber for the real-time determination of atmospheric formaldehyde, hydrogen peroxide and sulfur dioxide. Atmos Environ 22:949-963.
12. Feltham EJ, Almond MJ, Marston G, Ly VP, Wiltshire KS. 2000. Reactions of alkenes with ozone in the gas phase: a matrix-isolation study of secondary ozonides and carbonyl-containing reaction products. Spectrochim Acta A Mol Biomol Spectrosc 56(13):2605-2616.
13. Geiger H, Barnes I, Bejan I, Berner T, Spittler M. 2003. The tropospheric degradation of isoprene: an updated module for the regional atmospheric chemistry mechanism. Atmos Environ 37(11):1503-1519.
14. Gomes R, Meek ME. 2002. Concise International Chemical Assessment Document 43: Acrolein. Geneva:World Health Organization.
15. Gray TE, Guzman K, Davis CW, Abdullah LH, Nettesheim P. 1996. Mucocilliary differentiation of serially passaged normal human tracheobronchial epithelial cells. Am J Respir Cell Mol Biol 14(1):104-112.
16. Guenther AB, Zimmerman PR, Harley PC. 1993. Isoprene and monoterpene emission rate variability: model evaluations and sensitivity analyses. J Geo Res 99(D7):12609-12617.
17. Hughes K, Meek ME, Walker M, Beauchamp R. 2001. Concise International Chemical Assessment Document 30: 1,3-Butadiene. Geneva:World Health Organization.
18. IARC. 1992. 1,3-Butadiene. IARC Monogr Eval Carcinog Risks Hum 54:237-285.
19. IARC. 1994. Isoprene. IARC Monogr Eval Carcinog Risks Hum 60:215-232.
20. Jaspers I, Flescher E, Chen LC. 1997. Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells. Am J Physiol 272(3 pt 1):L504-L511.
21. Jaspers I, Zhang W, Fraser A, Samet JM, Reed W. 2001. Hydrogen peroxide has opposing effects on IKK activity and Iκ Bα breakdown in airway epithelial cells. Am J Respir Cell Mol Biol 24(6):769-777.
22. Jeffries HE, Fowler B. 2000. The University of North Carolina outdoor smog chamber. Chapel Hill, NC:University of North Carolina. Available: http://airchem.sph.unc.odu/Research/Facilities/UNCChamber/ [accessed 18 January 2004].
23. Jeffries HE, Fox DL, Kamens RM. 1976. Outdoor smog chamber studies: light effects relative to indoor chambers. Environ Sci Technol 10(10):1006-1011.
24. Jenkin ME, Boyd AA, Lesclaux R. 1998. Peroxy radical kinetics resulting from the OH-initiated oxidation of 1,3-butadiene, 2,3-dimethyl-1,3-butadiene and isoprene. J Atmos Chem 35(3):267-298.
25. Krishna MT, Springall D, Meng QH, Withers N, Macleod D, Biscione G, et al. 1997. Effects of ozone on epithelium and sensory nerves in the bronchial mucosa of healthy humans. Am J Respir Crit Care Med 156:943-950.
26. Larsen BR, Di Bella D, Glasius M, Winterhalter R, Jensen NR, Hjorth J. 2001. Gas-phase OH oxidation of monoterpenes: gaseous and particulate products. J Atmos Chem 38(3):231-276.
27. Larsen ST, Nielsen GD. 2000. Effects of methacrolein on the respiratory tract in mice. Toxicol Lett 114:197-202.
28. Lippmann M. 1989. Health effects of ozone: a critical review. J Air Waste Manage Assoc 39(5):672-695.
29. Liteplo RG, Beauchamp R, Meek ME, Chénier R. 2002. Concise International Chemical Assessment Document 40: Formaldehyde. Geneva:World Health Organization.
30. Liu X, Jeffries HE, Sexton KG. 1999. Hydroxyl radical and ozone initiated photochemical reactions of 1,3-butadiene. Atmos Environ 33:3005-3022.
31. Medinsky MA, Bond JA. 2001. Sites and mechanisms for uptakes of gases and vapors in the respiratory tract. Toxicology 160(1-3):165-172.
32. Mehlman MA, Borek C. 1987. Toxicity and biochemical mechanisms of ozone. Environ Res 42:36-53.
33. 1 Mice (Inhalation Studies). Technical Report 440. Research Triangle Park, NC:National Toxicology Program. Available: http://ehp.niehs.nih.gov/ntp/members/tr440/TR-440.PDF [accessed 17 September 2004].
34. NTP. 2002. 10th Report on Carcinogens. Research Triangle Park, NC:National Toxicity Program.
35. OSHA. 2002, Safety and Health Topics: 1,3-Butadiene. Washington, DC:Occupational Safety and Health Administration. Available: http://www.osha.gov/SLTC/butadiene/ [accessed 18 January 2004].
36. Palen EJ, Allen DT, Pandis SN, Paulson SE, Seinfeld JH, Flagan RC. 1992. Fourier transform infrared analysis of aerosol formed in the photo-oxidation of isoprene and [beta]-pinene. Atmos Environ 26:1239-1251.
37. Reimann S, Calanca P, Hofer P. 2000. The anthropogenic contribution to isoprene concentrations in a rural atmosphere. Atmos Environ 34(1):109-115.
38. Rohr A, Wilkins C, Clausen P, Hammer M, Nielsen G, Wolkoff P, et al. 2002. Upper airway and pulmonary effects of oxidation products of (+)-α-pinene, d-limonene, and isoprene in BALB/c mice. Inhal Toxicol 14:663-684.
39. Samet JM, Noah TL, Devlin RB, Yankaskas JR, McKinnon K, Dailey LS, et al. Effect of ozone on platelet-activating factor production in phorbol-differentiated HL60 cells, a human bronchial epithelial cell line (BEAS S6), and primary human bronchial epithelial cells. Am J Respir Cell Mol Biol 7(5):514-522.
40. Sauer F, Schafer C, Neeb P, Horie O, Moortgat GK. 1999. Formation of hydrogen peroxide in the ozonolysis of isoprene and simple alkenes under humid conditions. Atmos Environ 33:229-241.
41. Schlosser PM. 1999. Relative roles of convection and chemical reaction for the deposition of formaldehyde and ozone in nasal mucus. Inhal Toxicol 11(10):967-980.
42. Sexton KG, Jaspers I, Jeffries HE, Jang M, Kamens RM, Doyle M, et al. 2004. Smog chambers experiments of urban mixtures enhance inflammatory responses in lung cells. Inhal Toxicol 16(suppl 1):107-114.
43. Sorsa M, Osterman-Golkar S, Peltonen K, Saarikoski ST, Sram R. 1996. Assessment of exposure to butadiene in the process industry. Toxicology 113:77-83.
44. Thorton-Manning JR, Dahl AR, Bechtold WE, Griffith WC Jr, Henderson RF. 1997. Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation. Toxicology 123:125-137.
45. x. Int J Chem Kinet 22:1221-1236.
46. U.S. EPA 2001. Air Toxics Website. Research Triangle Park, NC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/ttn/atw/urban/list33.html [accessed 18 January 2004].
47. Wayne RP, Barnes I, Biggs P, Burrows JP, Canosa-Mas CE, Hjorth J, et al. 1991. The nitrate radical: physics, chemistry, and the atmosphere. Atmos Environ 25A:1-203.
48. WHO. 1978. Principles and Methods for Evaluating the Toxicity of Chemicals Part 1. Environmental Health Criteria 6. Geneva:World Health Organization.
49. WHO. 1989. Formaldehyde. Environmental Health Criteria 89. Geneva:World Health Organization.
50. WHO. 1991. Acrolein. Environmental Health Criteria 127. Geneva:World Health Organization.
51. WHO. 1995. Acetaldehyde. Environmental Health Criteria 167. Geneva:World Health Organization.
52. Wilkins CK, Clausen PA, Wolkoff P, Larsen ST, Hammer M, Larsen K, et al. 2001. Formation of strong airway irritants in mixtures of isoprene/ozone and isoprene/ozone/nitrogen dioxide. Environ Health Perspect 109:937-941.
53. Yu J, Jeffries HE. 1997. Atmospheric photooxidation of alkylbenzenes - II. Evidence of formation of epoxide intermediates. Atmos Environ 31(15):2281-2287.
54. Yu J, Jeffries HE, Le Lacheur RM. 1995. Identifying airborne carbonyl compounds in isoprene atmospheric photooxidation products by their PFBHA oximes using gas chromatography/ion trap mass spectrometry. Environ Sci Technol 29:1923-1932.