Effect of a change in crystal polymorph on the degree of adhesion between micronized drug particles and large homogenous carrier particles during an interactive mixing process

Pharmaceutical Development and Technology

Volumn 9, Issue 4, 2004, Pages 387-398

  Song, Mingna ^a   De Villiers, Melgardt M ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Cohesiveness; Drug carrier affinity; Interactive mixing; Polymorph

Indexed keywords

ALCOHOL; CHLORAMPHENICOL PALMITATE; CHLOROFORM; DRUG CARRIER; METHANOL; SUGAR;

ADHESION; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ANALYSIS; DRUG BINDING; DRUG MIXTURE; DRUG SCREENING; FILTRATION; LIGHT ABSORPTION; MIXER; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TIME; X RAY POWDER DIFFRACTION;

ADHESIVENESS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHLORAMPHENICOL; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG CARRIERS; MICROSPHERES; MOLECULAR CONFORMATION; PARTICLE SIZE; PHOTOMICROGRAPHY; POWDERS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 8744227917     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.1081/PDT-200033006     Document Type: Article

References (22)

1. Harnby, N. An engineering view of pharmaceutical powder mixing. Pharm. Sci. Technol. Today 2000, 3 (9), 303-309.
2. Fan, L.T.; Chen, Y. Recent developments in solids mixing. Powder Technol. 1990, 61, 255-287.
3. Hersey, J.A. Ordered mixing: a new concept in powder mixing practice. Powder Technol. 1975, 11, 41-44.
4. Egermann, H. Effects of adhesion on mixing homogeneity, part I: ordered adhesion-random adhesion. Powder Technol. 1980, 27, 203-206.
5. Staniforth, J.N. Relationship between vibration produced during powder handling and segregation of pharmaceutical powder mixed. Int. J. Pharm. 1982, 12, 199-207.
6. De Villiers, M.M.; Van der Watt, J.G. The measurement of mixture homogeneity and dissolution to predict the degree of drug agglomerate dispersion achieved through powder mixing. Pharm. Res. 1994, 11 (11), 1558-1662.
7. Podczeck, F. Particle adhesion in powder assemblies. In Particle-Particle Adhesion in Pharmaceutical Powder Handling; Imperial College Press. London, 1997; 111-114.
8. Kulvanich, P.; Stewart, P.J. The effect of particle size and concentration on the adhesive characteristics of a model drug-carrier interactive system. J. Pharm. Pharmacol. 1987, 39 (9), 673-678.
9. Crooks, M.J.; Ho, R. Ordered mixing in direct compression of tablets. Powder Technol. 1976, 14, 161-167.
10. Yip, C.W.; Hersey, J.A. Segregation in ordered powder mixtures. Powder Technol. 1977, 16, 149-150.
11. Berard, V.; Lesniewska, E.; Andres, C.; Pertuy, D.; Laroche, C.; Pourcelot, Y. Affinity scale between a carrier and a drug in DPI studied by atomic force microscopy. Int. J. Pharm. 2002, 247 (1-2), 127-137.
12. De Villiers, M.M.; Van der Watt, J.G.; Lötter, A.P. Influence of surfactants and interactive mixing on the cohesive properties of a poorly wettable solid. Powder Technol. 1993, 75 (2), 159-165.
13. Armstrong, N.A.; Reier, G.E.; Wadke, D.A. Handbook of Pharmaceutical Excipients, 2nd Ed.; Wadke, A., Weller, P.J., Eds.; The Pharmaceutical Press: London, 1994; 294-298.
14. Mackin, L.A.; Rowley, G.; Fletcher, E.J. An investigation of carrier particle type, electrostatic charge and relative humidity on in-vitro drug deposition from dry powder inhaler formulations. Pharm. Sci. 1997, 3 (12), 583-586.
15. Henwood, S.Q.; Liebenberg, W.; Lötter, A.P.; De Villiers, M.M. Characterization of several new rifampicin polymorphs, solvates and hydrates. Drug Dev. Ind. Pharm. 2001, 27 (10), 1017-1030.
16. Swanepoel, E.; Liebenberg, W.; De Villiers, M.M. Quality evaluation of generic drugs by dissolution test: changing the USP dissolution medium to distinguish between active and non-active mebendazole polymorphs. Eur. J. Pharm. Biopharm. 2003, 55 (3), 345-349.
17. Crookes, D.L. Aminoalkyl Furan Derivative. U.S. Patent 4,521,431, June 4, 1985.
18. Bernstein, J. Analytical techniques for studying and charactering polymorphs. In Polymorphism in Molecular Crystals; Int. Union Crystallogr. Monogr. Crystallogr., Clarendon Press: Oxford, 2002; Vol. 14, 144-146.
19. De Villiers, M.M. Influence of the cohesive behavior of micronized drug powders on particle size analysis. J. Pharm. Biomed. Anal. 1995, 13 (3), 191-199.
20. De Villiers, M.M. ; Van der Watt, J.G.; Lötter, A.P. Influence of the cohesive behaviour of small particles on the solid-state photolytic degradation of furosemide. Drug Dev. Ind. Pharm. 1993, 19 (3), 383-394.
21. Aguiar, A.J.; Krc, J.; Kinkel, A.W.; Samyn, J.C. Effect of polymorphism on the adsorption of chloramphenicol palmitate. J. Pharm. Sci. 1967, 56 (7), 847-853.
22. Otsuka, M.; Kaneniwa, N. Effect of seed crystals on solid-state transformation of polymorphs of chloramphenicol palmitate during grinding. J. Pharm. Sci. 1986, 75 (5), 506-511.