Synthesis of 2-ethoxycarbonyl-2-bromo-4-methyl-4-substituted butanolides and new spiroheteryl-joint butanolides based thereon

Synthetic Communications

Volumn 34, Issue 22, 2004, Pages 4219-4225

  Kochikyan, Tariel ^a  

^a YEREVAN STATE UNIVERSITY   (Armenia)

Author keywords

Benzimidazole; Benzthiazole; Bromolactone; Lactone; Spiroheterocycle

Indexed keywords

2 AZA 3 AMINO 4 THIA 7 OXA METHYL 8 SPIRO[4 4] 2 NONENE 1,6 DIONE; 2 ETHOXYCARBONYL 2 (2 BENZIMIDAZOLYLTHIO) 4,4 DIMETHYBUTANOLIDE; 2 ETHOXYCARBONYL 2 BROMO 4 METHYL 4 BUTANOLIDE; 2 ETHOXYCARBONYL 2 BROMO 4,4 DIMETHYLBUTANOLIDE; BROMINE; BUTYROLACTONE; CARBON TETRACHLORIDE; KETONE DERIVATIVE; LACTONE DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG;

ARTICLE; BROMINATION; CYCLIZATION; SUBSTITUTION REACTION; SYNTHESIS;

EID: 8644282713     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-200036633     Document Type: Article

References (9)

1. Richard, A.; Marcello de Moura, C.; Kenneth, L. The mechanism of the reaction of bromine with γβ-unsaturated acids. J. Am. Chem. Soc. 1953, 75 (5), 1044.
2. Zebic, V.; Skaric, V.; Ruzic-Toros, Z.; Kojic-Prodic, B. Bromolactone structures derived from cyclex-3-ene-1,1-dicarboxylic acids. Croat. Chem. Acta 1986, 59 (2), 491.
3. Haroutyunyan, V.S.; Kochikyan, T.V.; Nalbandyan, Z.Y.; Samvelyan, M.A.; Avetissyan, A.A. New method for obtaining 4-alkoxymethyl-2-acetonyl-butanolides. J. Org. Chem. 2001, 37 (1), 119.
4. Dickel, D.; De Stevens, G. Indolylalkanoic acid lactones. US Patent 3, 686, 211, August 22, 1971.
5. Haroutyunyan, V.S.; Kochikyan, T.V.; Kovalev, G.V.; Bugaeva, L.I.; Antadze, M.G. Synthesis and preliminary results of biological studies of new mercaptotriazolil γ-lactones. Arm. Chem. J., 1985, 38 (11), 668.
6. Haroutyunyan, V.S.; Kochikyan, T.V.; Avetissyan, A.A.; Korpakowa, I.G. Lactone-containing thiosemicarbazones possessing anti-mutagenous activity. Armenian Patente 1078, 8 May, 2002.
7. Hella, I.M.; Sernienko, L.Y.; Chernenko, A.H. Anti-antrogenic activity of some steroid spirolactones. Chem. Pharm. J. 1990, 24, 29.
8. Ferai, H.; Craire, M.; Rondot, A.; Aumelas, A.; Aizou, G. Synthesis of new steroida 11-β-substituded spirolactones. J. Chem. Soc. Perkin. Trans. 1990, 1 (11), 3045.
9. Haroutyunyan, V.S.; Kochikyan, T.V.; Egiazaryan, H.C.; Avetissyan, A.A. A method for obtained 2-acetonyl-4-substituted-4-pentanolids. Chem. J. Arm. 1994, 47 (1-3), 88.