A convenient procedure for parallel ester hydrolysis

Synlett

Volumn , Issue 13, 2004, Pages 2391-2393

  Anderson, Marc O ^a   Moser, Jamie ^a   Sherrill, John ^a   Guy, R Kiplin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

9 Chloroacridine; Barium hydroxide octahydrate; Deprotection; Ester hydrolysis; Parallel synthesis

Indexed keywords

BARIUM DERIVATIVE; BARIUM HYDROXIDE OCTAHYDRATE; CARBOXYLIC ACID; ESTER; HYDROCHLORIC ACID; METHANOL; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; HYDROLYSIS; PROTON TRANSPORT; REACTION ANALYSIS; SOLUBILITY; SYNTHESIS;

EID: 8644275496     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-832828     Document Type: Article

References (12)

1. Manchand, P. S. J. Chem. Soc., Chem. Commun. 1971, 13, 667.
2. Felix, A. M. J. Org. Chem. 1974, 39, 1427.
3. Magnus, P.; Gallagher, T. J. Chem. Soc., Chem. Commun. 1984, 389.
4. For example: (a) Inoue, K.; Sakai, K. Tetrahedron Lett. 1977, 46, 4063.
5. (b) Bascop, S.-L.; Laronze, J.-Y.; Sapi, J. Synthesis 2002, 1689.
6. (c) Papot, S.; Rivault, F.; Tranoy, I.; Gesson, J.-P. Synlett 2002, 164.
7. Ahman, J.; Buchwald, S. L. Tetrahedron Lett. 1997, 38, 6363.
8. (a) Maxime, R.; Faure, R.; Perichaud, A.; Galy, J.-P. Synth. Commun. 2002, 32, 981.
9. (b) Lormier, A. T.; Boyer, G.; Gaure, R.; Galy, J. P. Heterocycles 2002, 57(3), 449.
10. (c) Cain, B. F.; Atwell, G. J. J. Med. Chem. 1976, 19, 1408.
11. (d) Acheson, R. M.; Harvey, C. W. C. J. Chem. Soc., Perkin Trans, 1 1976, 465.
12. 4, and the mixture was filtered, and concentrated to afford salicylic acid (0.115g, 87%).