Renal cell carcinoma MIB-1, Bax and Bcl-2 expression and prognosis

Journal of Urology

Volumn 172, Issue 6 I, 2004, Pages 2158-2161

  Kallio, Jukka P ^a,c   Hirvikoski, Pasi ^b   Helin, Heikki ^a   Luukkaala, Tiina ^a   Tammela, Teuvo L J ^a   Kellokumpu Lehtinen, Pirkko ^a   Martikainen, Paula M ^a  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Apoptosis; Carcinoma, renal cell; Gene expression; Kidney; Prognosis

Indexed keywords

KI 67 ANTIGEN; PROTEIN BAX; PROTEIN BCL 2;

ADULT; AGED; ARTICLE; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEPHRECTOMY; PRIORITY JOURNAL; PROGNOSIS;

EID: 8644275409     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000144334.97639.bf     Document Type: Article

References (20)

1. Harris, M. H. and Thompson, C. B.: The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability. Cell Death Differ, 7: 1182, 2000
2. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D. and Korsmeyer, S. J.: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature, 348: 334, 1990
3. Miyashita, T. and Reed, J. C.: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell, 80: 293, 1995
4. Sedlak, T. W., Oltvai, Z. N., Yang, E., Wang, K., Boise, L. H., Thompson, C. B. et al: Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA, 92: 7834, 1995
5. Vasavada, S. P., Novick, A. C. and Williams, B. R.: P53, bcl-2, and Bax expression in renal cell carcinoma. Urology, 51: 1057, 1998
6. Paraf, F., Gogusev, J., Chretien, Y. and Droz, D.: Expression of bcl-2 oncoprotein in renal cell tumours. J Pathol, 177: 247, 1995
7. Lipponen, P., Eskelinen, M. and Syrjanen, K.: Expression of tumour-suppressor gene Rb, apoptosis-suppressing protein Bcl-2 and c-Myc have no independent prognostic value in renal adenocarcinoma. Br J Cancer, 71: 863, 1995
8. Tomita, Y., Saito, T., Saito, K., Oite, T., Shimizu, F. and Sato, S.: Possible significance of VLA-4 (alpha 4 beta 1) for hematogenous metastasis of renal-cell cancer. Int J Cancer, 60: 753, 1995
9. Hofmockel, G., Wittmann, A., Dammrich, J. and Bassukas, I. D.: Expression of p53 and bcl-2 in primary locally confined renal cell carcinomas: no evidence for prognostic significance. Anticancer Res, 16: 3807, 1996
10. Oudard, S., Levalois, C., Andrieu, J. M., Bougaran, J., Validire, P., Thiounn, N. et al: Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome. Anticancer Res, 22: 121, 2002
11. Kallio, J. P., Hirvikoski, P., Helin, H., Kellokumpu-Lehtinen, P., Luukkaala, T., Tammela, T. L. et al: Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma. Br J Cancer, 89: 1266, 2003
12. Rautiainen, E., Haapasalo, H., Sallinen, P., Rantala, I., Helen, P. and Helin, H.: Histone mRNA in-situ hybridization in astrocytomas: a comparison with PCNA, MIB-1 and mitoses in paraffin-embedded material. Histopathology, 32: 43, 1998
13. Kovacs, G., Akhtar, M., Beckwith, B. J., Bugert, P., Cooper, C. S., Delahunt, B. et al: The Heidelberg classification of renal cell tumours. J Pathol, 183: 131, 1997
14. Fuhrman, S. A., Lasky, L. C. and Limas, C.: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol, 6: 655, 1982
15. Yang, B., Gu, F., Li, H., Kong, X. and Yu, L.: Apoptosis of renal cell carcinoma and apoptotic related genes bcl-2 and bax. Zhonghua Wai Ke Za Zhi, 36: 373, 1998
16. Lipponen, P., Pietilainen, T., Kosma, V. M., Aaltomaa, S., Eskelinen, M. and Syrjanen, K.: Apoptosis suppressing protein bcl-2 is expressed in well-differentiated breast carcinomas with favourable prognosis. J Pathol, 177: 49, 1995
17. Tormanen, U., Eerola, A. K., Rainio, P., Vahakangas, K., Soini, Y., Sormunen, R. et al: Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma. Cancer Res, 55: 5595, 1995
18. Gobe, G., Rubin, M., Williams, G., Sawczuk, I. and Buttyan, R.: Apoptosis and expression of Bcl-2, Bel-XL, and Bax in renal cell carcinomas. Cancer Invest, 20: 324, 2002
19. Devarajan, P., De Leon, M., Talasazan, F., Schoenfeld, A. R., Davidowitz, E. J. and Burk, R. D.: The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways. J Biol Chem, 276: 40599, 2001
20. Gobe, G., Zhang, X. J., Willgoss, D. A., Schoch, E., Hogg, N. A. and Endre, Z. H.: Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat. J Am Soc Nephrol, 11: 454, 2000