NF-κB and the immunoglobulin κ gene enhancer

Journal of Experimental Medicine

Volumn 200, Issue 9, 2004, Pages 1099-1102

  Sen, Ranjan ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN KAPPA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

CELL LINEAGE; ENHANCER REGION; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; INTRON; PRIORITY JOURNAL; RECEPTOR GENE; REVIEW; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION INITIATION; ARTICLE; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM;

ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; MODELS, GENETIC; NF-KAPPA B; RECEPTORS, ANTIGEN, B-CELL;

EID: 8644252062     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20041255     Document Type: Review

References (24)

1. Calame, K., and R. Sen. 2003. Transcription of immunoglobulin genes. In Molecular Biology of B Cells. T. Honjo, F. Alt, and M. Neuberger, editors. Elsevier Science Publishing Co. Inc., New York. 79-96 pp.
2. Schlissel, M.S., and D. Baltimore. 1989. Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell. 58:1001-1007.
3. Klug, C.A., S.J. Gerety, P.C. Shah, Y.Y. Chen, N.R., Rice, N. Rosenberg, and H. Singh. 1994. The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes. Genes Dev. 8:678-687.
4. Scherer, D.C., J.A. Brockman, H.H. Bendall, G.M. Zhang, D.W. Ballard, and E.M. Oltz. 1996. Corepression of RelA and c-rel inhibits immunoglobulin kappa gene transcription and rearrangement in precursor B lymphocytes. Immunity. 5:563-574.
5. Lenardo, M., J.W. Pierce, and D. Baltimore. 1987. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science. 236:1573-1577.
6. Demengeot, J., E.M. Oltz, and F.W. Alt. 1995. Promotion of V(D)J recombinational accessibility by the intronic E kappa element: role of the kappa B motif. Int. Immunol. 7:1995-2003.
7. Kirillov, A., B. Kistler, R. Mostoslavsky, H. Cedar, T. Wirth, and Y. Bergman. 1996. A role for nuclear NF-kappaB in B-cell-specific demethylation of the Igkappa locus. Nat. Genet. 13:435-441.
8. Amit, S., and Y. Ben-Neriah. 2003. NF-kappaB activation in cancer: a challenge for ubiquitination- and proteasome-based therapeutic approach. Semin. Cancer Biol. 13:15-28.
9. Smahi, A., G. Courtois, S.H. Rabia, R. Doffinger, C. Bodemer, A. Munnich, J.L. Casanova, and A. Israel. 2002. The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. Hum. Mol. Genet. 11:2371-2375.
10. K rearrangement. J. Exp. Med. 200:1205-1211.
11. Xu, Y., L. Davidson, F.W. Alt, and D. Baltimore. 1996. Deletion of the Ig kappa light chain intronic enhancer/matrix attachment region impairs but does not abolish V kappa J kappa rearrangement. Immunity. 4:377-385.
12. Kee, B.L., M.W. Quong, and C. Murre. 2000. E2A proteins: essential regulators at multiple stages of B-cell development. Immunol. Rev. 175:138-149.
13. Saijo, K., C. Schmedt, I.H. Su, H. Karasuyama, C.A. Lowell, M. Reth, T. Adachi, A. Patke, A. Santana, and A. Tarakhovsky. 2003. Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat. Immunol. 4:274-279.
14. Tretter, T., A.E. Ross, D.I. Dordai, and S. Desiderio. 2003. Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk. J. Exp. Med. 198:1863-1873.
15. Shaffer, A.L., A. Peng, and M.S. Schlissel. 1997. In vivo occupancy of the kappa light chain enhancers in primary pro- and pre-B cells: a model for kappa locus activation. Immunity. 6:131-143.
16. Zhong, H., M.J. May, E. Jimi, and S. Ghosh. 2002. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol. Cell. 9:625-636.
17. Ashburner, B.P., S.D. Westerheide, and A.S. Baldwin Jr. 2001. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell. Biol. 21:7065-7077.
18. Zhong, H., R.E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661-671.
19. Sheppard, K.A., D.W. Rose, Z.K. Haque, R. Kurokawa, E. McInerney, S. Westin, D. Thanos, M.G. Rosenfeld, C.K. Glass, and T. Collins. 1999. Transcriptional activation by NF-kappaB requires multiple coactivators. Mol. Cell. Biol. 19:6367-6378.
20. Romanow, W.J., A.W. Langerak, P. Goebel, I.L. Wolvers-Tettero, J.J. van Dongen, A.J. Feeney, and C. Murre. 2000. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol. Cell. 5:343-353.
21. Goebel, P., N. Janney, J.R. Valenzuela, W.J. Romanow, C. Murre, and A.J. Feeney. 2001. Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells. J. Exp. Med. 194:645-656.
22. Liang, H.E., L.Y. Hsu, D. Cado, and M.S. Schlissel. 2004. Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression. Cell. 118:19-29.
23. Mostoslavsky, R., N. Singh, A. Kirillov, R. Pelanda, H. Cedar, A. Chess, and Y. Bergman. 1998. Kappa chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12:1801-1811.
24. Bird, A.P., and A.P. Wolffe. 1999. Methylation-induced repression-belts, braces, and chromatin. Cell. 99:451-454.