Hypoxemic reperfusion after 120 mins of intestinal ischemia attenuates the histopathologic and inflammatory response

Critical Care Medicine

Volumn 32, Issue 11, 2004, Pages 2279-2283

  Douzinas, Emmanuel E ^a   Kollias, Spiridon ^a   Tiniakos, Dina ^a   Evangelou, Evangelos ^a   Papalois, Apostolos ^b   Rapidis, Alexandros D ^c   Tsoukalas, George D ^d   Patsouris, Efstratios ^a   Roussos, Charis ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b ELPEN Pharmaceuticals   (Greece)

^c Greek Anticancer Institute   (Greece)

^d EVANGELISMOS HOSPITAL   (Greece)

Author keywords

Endotoxin; Hypoxemic reperfusion; Interleukin 1 ; Intestinal injury score; Pao2 Fio2; Pulmonary injury score; Reactive oxygen species

Indexed keywords

INTERLEUKIN 1; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOXEMIA; HYPOXEMIC REPERFUSION; INFLAMMATION; INTESTINE BIOPSY; INTESTINE INJURY; INTESTINE ISCHEMIA; ISCHEMIA; LIMULUS LYSATE TEST; LUNG BIOPSY; LUNG INJURY; MALE; NONHUMAN; OXYGEN TENSION; PORTAL VEIN BLOOD; PRIORITY JOURNAL; REPERFUSION; SHOCK; SUPERIOR MESENTERIC ARTERY; SWINE; TISSUE INJURY;

ANIMALS; ANOXEMIA; BIOPSY; BLOOD GAS ANALYSIS; DISEASE MODELS, ANIMAL; FLUID THERAPY; ILEUM; INFLAMMATION; INTERLEUKIN-1; ISCHEMIA; LUNG; MALE; MESENTERIC ARTERY, SUPERIOR; MULTIPLE ORGAN FAILURE; OXYGEN; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; REPERFUSION; REPERFUSION INJURY; SWINE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TIME FACTORS; TREATMENT OUTCOME;

EID: 8544280756     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000145582.03345.C8     Document Type: Article

References (22)

1. Caty MG, Guice KS, Oldham KT, et al: Evidence for tumor necrosis factor-induced pulmonary microvascular injury after intestinal ischemia reperfusion injury. Ann Surg 1990; 212:694-700
2. Hill J, Lindsay T, Rusche J, et al: A Mac-1 antibody reduces liver and lung injury but not neutrophil sequestration after intestinal ischemia-reperfusion. Surgery 1992; 112:166-172
3. Welborn MB, Oldenburg HSA, Hess PJ, et al: The relationship between visceral ischemia, proinflammatory cytokines, and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair. Crit Care Med 2000; 28:3191-3197
4. Granger DN, Rutili G, McCord JM: Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981; 81:22-29
5. Parks DA, Bulkley GB, Granger DN, et al: Ischemic injury in the cat small intestine: Role of superoxide radicals. Gastroenterology 1982; 82:9-15
6. Granger DN, McCord JM. Parks DA, et al: Xanthine oxidase inhibition attenuates ischemia induced vascular permeability changes in the cat intestine. Gastroenterology 1986; 90:80-90
7. Paparella A, Deluca FG, Oyer CE, et al: Ischemia-reperfusion injury in the intestines of newborn pigs. Pediatr Res 1997; 42:180-188
8. Douzinas EE, Pitaridis MT, Patsouris E, et al: Myocardial ischemia in intestinal postischemic shock: The effect of hypoxemic reperfusion. Crit Care Med 2003; 31:2183-2189
9. Sautner T, Wessely C, Riegler M, et al: Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock. Ann Surg 1998; 228:239-248
10. Chiu CJ, McArdle AH, Brown R, et al: Intestinal mucosal lesion in low-flow states. Arch Surg 1970; 101:478-483
11. Simpson R, Alon R, Kobzik L, et al: Neutrophil and nonneutrophil-mediated injury in intestinal ischemia-reperfusion. Ann Surg 1993; 218:453-454
12. The Parenteral Society: Technical Monograph No 6: Guideline on LAL. The Parenteral Society
13. Nilsson UA, Schoenberg MH, Aneman A, et: Free radicals and pathogenesis during ischemia and reperfusion of the cat small intestine. Gastrenterology 1994; 106:629-636
14. Blikslager AT, Roberts MC, Rhoads JM, et al: Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia? Surgery 1997; 121:526-534
15. Zhengwu S, Wang X, Lasson A, et al: Roles of platelet-activating factor, interleukin-1β and interleukin-6 in intestinal barrier dysfunction induced by mesenteric arterial ischemia and reperfusion. J Surg Res 1999; 87:90-100
16. Rossman JE, Caty MG, Zheng S, et al: Mucosal protection from intestinal ischemia-reperfusion reduces oxidant injury to the lung. J Surg Res 1997; 73:41-46
17. Tamion F, Richard V, Bonmarchand G, et al: Reduced synthesis of inflammatory cytokines by a free radical scavenger after hemorrhagic shock in rats. Crit Care Med 2000; 28:2522-2527
18. Younkin DP, Wagerle LC, Chance B, et al: 31P-NMR studies of cerebral metabolic changes during graded hypoxia in newborn lambs. J Appl Physiol 1987; 62:1569-15674
19. Turnage RH, Guice KS, Oldham KT: Pulmonary microvascular injury following intestinal reperfusion. New Horiz 1994; 2:463-475
20. Koksoy C, Kuzu MA, Kuzu I, et al: Role of tumour necrosis factor in lung injury caused by intestinal ischaemia-reperfusion. Br J Surg 2001; 88:464-468
21. Galili Y, Ben-Abraham R, Weinbroum A, et al: Methylene blue prevents pulmonary injury after intestinal ischemia-reperfusion. J Trauma 1998; 45:222-226
22. Horton JW, White DJ: Lipid peroxidation contributes to cardiac deficits after ischemia and reperfusion of the small bowel. Am J Physiol 1993; 264:H1686-H1692