Polyurethanes loaded with antibiotics: Influence of polymer-antibiotic interactions on in vitro activity against Staphylococcus epidermidis

Journal of Chemotherapy

Volumn 16, Issue 5, 2004, Pages 446-452

  Piozzi, A ^a   Francolini, I ^a,b   Occhiaperti, L ^a   Di Rosa, R ^a   Ruggeri, V ^a   Donelli, G ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Antibiotic; Biofilms; Catheter related infections; Polyurethanes

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; CEFAMANDOLE NAFATE; POLYMER; POLYURETHAN; RIFAMPICIN; TERTIARY AMINE; VANCOMYCIN;

ACIDITY; AGAR MEDIUM; ALKALINITY; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CONTROLLED STUDY; CORRELATION ANALYSIS; DEVICE INFECTION; DRUG ADSORPTION; DRUG MECHANISM; DRUG RELEASE; DRUG STRUCTURE; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 8544273681     PISSN: 1120009X     EISSN: None     Source Type: Journal    
DOI: 10.1179/joc.2004.16.5.446     Document Type: Article

References (24)

1. Bouza E, Burillo A, Munoz P. Catheter-related infections: diagnosis and intravascular treatment. Clin Microbiol Infect 2002; 8(5): 265-74.
2. Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microrganisms. Clin Microbiol Rev 2002; 15: 167-193.
3. Donetz AP, Harvey RA, Greco RS. Stability of antibiotics to polytetrafluoroethylene with cationic surfactants. J Clin Microb 1984; 19 (1): 1-3.
4. Maki DG, Stolz SM, Wheeler SJ, Mermel LA. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter. Ann Intem Med 1997; 127(4): 257-266.
5. Sherertz RJ, Carruth WA, Hampton AA, Byron MP, Solomon DD. Efficacy of antibiotic-coated catheters in preventing subcutaneous Staphylococcus aureus infection in rabbit. J Infect Dis 1993; 167: 98-106.
6. O'Grady NP, Alexander M., Dellinger EP et al. Guidelines for the prevention of intravascular catheter-related infections. Center for Disease Control and Prevention. MMWR 2002; 9 (51): 1-29.
7. Mah TF, O'Toole GA. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001; 9: 34-39.
8. Donelli G, De Paoli P, Fadda G, Marone P, Nicoletti G, Varaldo PE. A multicenter study on central venous catheter-associated infections in Italy. J Chemother 2001; 13 Spec No 1: 251-262.
9. Donelli G, Francolini I. Efficacy of antiadhesive, antibiotic and antiseptic coatings in preventig catheter-related infections: review. J Chemother 2001; 13 (6): 56-67.
10. Marconi W, Galoppa A, Martinelii A, Piozzi A. New polyurethane compositions able to bond high amounts of both albumin and heparin. II: Copolymers and polymer blends. Biomaterials 1996; 17(18): 1795-802.
11. Schierholz JM, Beuth J. Implant infections: a haven for opportunistic bacteria. J Hosp Infect 2001; 49(2): 87-93.
12. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet 2001; 358: 135-138.
13. Darouiche RO, Raad II, Heard SO et al. A comparison of two antimicrobial-impregnated central venous catheters. N Engl J Med 1999; 340: 1-8.
14. Raad I, Darouiche R, Hachem R, Mansouri M, Bodey GP. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J Infect Dis 1996; 173: 418-24.
15. O'Grady NP, Gerberding JL, Weinstein RA, Masur H. Patient safety and the science of prevention: the time for implementing the Guidelines for the prevention of intravascular catheter-related infections is now. Crit Care Med 2003; 31(1): 291-2.
16. Danese PN. Antibiofilm approaches: prevention of catheter colonization. Chem Biol 2002; 9: 873-880.
17. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999; 284: 1318-22.
18. Elliott TS. The prevention of central venous catheter-related sepsis. J Chemother 2001; 13: Spec No 1: 234-8.
19. Safdar N, Kluger DM, Maki DG. A review of risk factors for catheter-related bloodstream infection caused by percutaneously inserted, noncuffed central venous catheters: implications for preventive strategies. Medicine (Baltimore) 2002; 81(6): 466-79.
20. Marconi W, Francolini I, Piozzi A, Di Rosa R. Antibiotic releasing urethane polymers for prevention of catheter related infections. Bioact Compat Polym 2001; 16(5): 393-407.
21. Yorganci K, Krepel C, Weigelt JA, Edmiston CE. Activity of antibacterial impregnated central venous catheter against Klebsiella pneumoniae. Intensive Care Med 2002; 28: 438-442.
22. National Committee for clinical laboratory standards. Methods for dilution antimicrobial susceptability tests for bacteria that grow aerobically. M7-A2. National Committee for clinical laboratory standards, Villanova, Pa, 1990.
23. Mermel LA. New technologies to prevent intravascular catheter-related bloodstream infections. Emerg Infect Dis 2001; 7(2): 197-9.
24. Donelli G, Francolini I, Piozzi A, Di Rosa R, Marconi W. New polymer-antibiotic systems to inhibit bacterial biofilm formation: a suitable approach to prevent central venous catheter-associated infections. J Chemother 2002; 14 (5): 501-507.