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Volumn 32, Issue 11, 2004, Pages 2343-2344

Afelimomab - Another therapeutic option in sepsis therapy?

Author keywords

Afelimomab; Clinical trial; Interleukin 6; Sepsis; Tumor necrosis factor

Indexed keywords

CORTICOSTEROID; INTERLEUKIN 6; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

EID: 8544245713     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000146134.86536.2F     Document Type: Editorial
Times cited : (4)

References (15)
  • 1
    • 0035826096 scopus 로고    scopus 로고
    • Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
    • Bernard GR, Vincent JL, Laterre PF, et al: Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. N Engl J Med 2001; 344:699-709
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 2
    • 3042858950 scopus 로고    scopus 로고
    • Metaanalysis: The effect of steroids on survival and shock during sepsis depends on the dose
    • Minneci PC, Deans KJ, Banks SM, et al: Metaanalysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann Intern Med 2004; 141:47-56
    • (2004) Ann Intern Med , vol.141 , pp. 47-56
    • Minneci, P.C.1    Deans, K.J.2    Banks, S.M.3
  • 3
    • 0035829842 scopus 로고    scopus 로고
    • Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • Rivers E, Nguyen B, Havstad S, et al: Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. TV Engl J Med 2001; 345:1368-1377
    • (2001) TV Engl J Med , vol.345 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3
  • 4
    • 4143148570 scopus 로고    scopus 로고
    • Evidence-based medicine in the ICU: Important advances and limitations
    • Vincent JL. Evidence-based medicine in the ICU: Important advances and limitations, Chest 2004; 126:592-600
    • (2004) Chest , vol.126 , pp. 592-600
    • Vincent, J.L.1
  • 5
    • 8544262221 scopus 로고    scopus 로고
    • 2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
    • 2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit Care Med 2004; 32:2173-2182
    • (2004) Crit Care Med , vol.32 , pp. 2173-2182
    • Panacek, E.A.1    Marshall, J.C.2    Albertson, T.E.3
  • 6
    • 0037251585 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis
    • PROWESS Investigators
    • Ely EW, Laterre PF, Angus DC, et al: PROWESS Investigators. Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med 2003; 31:12-19
    • (2003) Crit Care Med , vol.31 , pp. 12-19
    • Ely, E.W.1    Laterre, P.F.2    Angus, D.C.3
  • 7
    • 0027406403 scopus 로고
    • Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis
    • The CB0006 Sepsis Syndrome Study Group
    • Fisher CJ Jr, Opal SM, Dhainaut JF, Stephens et al: Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med 1993; 21:318-327
    • (1993) Crit Care Med , vol.21 , pp. 318-327
    • Fisher Jr., C.J.1    Opal, S.M.2    Dhainaut, J.F.3    Stephens4
  • 8
    • 0029132699 scopus 로고
    • CDP571, a humanized antibody to human tumor necrosis factor-alpha: Safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock
    • CPD571 Sepsis Study Group
    • Dhainaut JF, Vincent JL, Richard C, et al: CDP571, a humanized antibody to human tumor necrosis factor-alpha: Safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock. CPD571 Sepsis Study Group. Crit Care Med 1995; 23: 1461-1469
    • (1995) Crit Care Med , vol.23 , pp. 1461-1469
    • Dhainaut, J.F.1    Vincent, J.L.2    Richard, C.3
  • 9
    • 0028957549 scopus 로고
    • Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial
    • TNF-alpha MAb Sepsis Study Group
    • Abraham E, Wunderink R, Silverman H, et al: Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group. JAMA 1995; 273:934-941
    • (1995) JAMA , vol.273 , pp. 934-941
    • Abraham, E.1    Wunderink, R.2    Silverman, H.3
  • 10
    • 0029835023 scopus 로고    scopus 로고
    • INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis
    • International Sepsis Trial Study Group
    • Cohen J, Carlet J: INTERSEPT: An international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 1996; 24:1431-1440
    • (1996) Crit Care Med , vol.24 , pp. 1431-1440
    • Cohen, J.1    Carlet, J.2
  • 11
    • 0032495658 scopus 로고    scopus 로고
    • Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
    • NORASEPT II Study Group
    • Abraham E, Anzueto A, Gutierrez G, et al: Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock. NORASEPT II Study Group. Lancet 1998; 351:929-933
    • (1998) Lancet , vol.351 , pp. 929-933
    • Abraham, E.1    Anzueto, A.2    Gutierrez, G.3
  • 12
    • 9344246862 scopus 로고    scopus 로고
    • Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study
    • Reinhart K, Wiegand-Lohnert C, Grimminger F, et al: Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 1996; 24: 733-742
    • (1996) Crit Care Med , vol.24 , pp. 733-742
    • Reinhart, K.1    Wiegand-Lohnert, C.2    Grimminger, F.3
  • 13
    • 0035046049 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study
    • Reinhart K, Menges T, Gardlund B, et al: Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study. Crit Care Med 2001; 29:765-769
    • (2001) Crit Care Med , vol.29 , pp. 765-769
    • Reinhart, K.1    Menges, T.2    Gardlund, B.3
  • 14
    • 3242717577 scopus 로고    scopus 로고
    • Public registration of clinical trials
    • Steinbrook R: Public registration of clinical trials. TV Engl J Med 2004; 351:315-317
    • (2004) TV Engl J Med , vol.351 , pp. 315-317
    • Steinbrook, R.1
  • 15
    • 1642456548 scopus 로고    scopus 로고
    • Adequacy of early empiric antibiotic treatment and survival in severe sepsis: Experience from the MONARCS trial
    • MacArthur RD, Miller M, Albertson T, et al: Adequacy of early empiric antibiotic treatment and survival in severe sepsis: Experience from the MONARCS trial. Clin Infect Dis 2004; 38:284-288
    • (2004) Clin Infect Dis , vol.38 , pp. 284-288
    • MacArthur, R.D.1    Miller, M.2    Albertson, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.