DNA ploidy, proliferative index and EGF-R status in 130 cases of resected gastric cancer - a multivariate analysis

Hepato-Gastroenterology

Volumn 44, Issue 15, 1997, Pages 826-837

  Santoro, Eugenio ^a   Carboni, Manlio ^b   Catarci, Marco ^b   Carlini, Massimo ^a   Carboni, Fabio ^a   Zupi, Gabriella ^a   Vecchione, Aldo ^c   D'Agnano, Igea ^a   Giannarelli, Diana ^a   Santoro, Roberto ^b   Garofalo, Alfredo ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

DNA ploidy; EGF R status; Gastric cancer; Proliferative index

Indexed keywords

CELL DNA; EPIDERMAL GROWTH FACTOR RECEPTOR;

ANEUPLOIDY; ARTICLE; CANCER INFILTRATION; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CELL PROLIFERATION; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PATHOLOGY; PLOIDY; PRIORITY JOURNAL; PROGNOSIS; REGRESSION ANALYSIS; STOMACH CANCER; STOMACH WALL; TUMOR VOLUME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CELL DIVISION; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PLOIDIES; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETROSPECTIVE STUDIES; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 8544237779     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Allum WH, Powell DJ, McConkey CC, Fielding JW. Gastric cancer: a 25-year review. Br J Surg 1989; 76: 535-540.
2. Hallissey MT, Dunn JA, Ward LC, Allum WH for the British Stomach Cancer Group. The second British Stomach Cancer Group trial of adjuvant radiotherapy or chemotherapy in resectable gastric cancer: five-year follow-up. Lancet 1994; 343: 1309-1312.
3. McCulloch P. Should general surgeons treat gastric carcinoma? An audit of practice and results, 1980-1985. Br J Surg 1994; 81: 417-420.
4. Hermans J, Bonenkamp JJ, Boon MC, Bunt AMG, Sasako M, Van de Velde CJH. Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials. J Clin Oncol 1993; 11: 1441-1447.
5. Carboni M, Guadagni S, Catarci M, Gossetti F, Negro P. Surgical treatment of gastric cancer: our elective procedures for desirable curability. In: Reed P, Carboni M, Johnston B, Guadagni S, eds. New trends in gastric cancer. London: Kluwer Academic Publishers, 1990: 135-150.
6. Santoro E, Garofalo A, Carlini M, Rinaldi G, Santoro E Jr. Early and late results of 100 consecutive total gastrectomies for cancer. Hepato-Gastroenterol 1994; 41: 489-496.
7. Maruyama K. The most important prognostic factors for gastric cancer patients, a study using univariate and multivariate analysis. Scand J Gastroenterol 1987; 22 (suppl 133): 63-68.
8. Merkel DE, McGuire WL. Ploidy, proliferative activity and prognosis, DNA flow cytometry of solid tumors. Cancer 1990; 63:1194-1205.
9. Silvestrini R, D'Agnano I, Faranda A et al. Flow cytometric analysis of ploidy in colorectal cancer: a multicentric experience. Br J Cancer 1993; 67: 1042-1046.
10. D'Agnano I, Cosimelli M, La Pera A et al. Flow cytometric analysis of DNA content and cell kinetics in colorectal carcinoma. Anticancer Res 1993; 13: 669-704.
11. Yonemura Y, Ohyama S, Sugiyama K et al. Retrospective analysis of the prognostic significance of DNA ploidy patterns and S-phase fraction in gastric carcinoma. Cancer Res 1990; 50: 509-514.
12. Ohyama S, Yonemura Y, Miyazaki I. Prognostic value of S-phase fraction and DNA ploidy studied with in vivo administration of bromodeoxyuridine on human gastric cancer. Cancer 1990; 65: 116-121.
13. Filipe MI, Rosa J, Sandey A, Imrie PR, Ormerod MG, Morris W. Is DNA ploidy and proliferative activity of prognostic value in advanced gastric cancer? Hum Pathol 1991; 22: 373-378.
14. Kimura H, Yonemura Y. Flow cytometric analysis of nuclear DNA content in advanced gastric cancer and its relationship with prognosis. Cancer 1991; 67: 2588-2593.
15. Johnson HJ, Bellucco C, Masood S, Abou-Azama AM, Kahn L, Wise L. The value of flow cytometric analysis in patients with gastric cancer. Arch Surg 1993; 128: 314-317.
16. Umehara Y, Kimura T, Yoshida M, Oba N, Harada Y. Heterogeneity in early and advanced gastric carcinoma by flow cytometric DNA analysis. J Surg Oncol 1993; 52: 97-100.
17. Rugge M, Sonego F, Panozzo M et al. Pathology and ploidy in the prognosis of gastric cancer with no extranodal metastasis. Cancer 1994; 73: 1127-1133.
18. Yonemura Y, Sugiyama K, Ohyama S et al. Epidermal growth factor receptor status and S-phase frections in gastric carcinoma. Oncology 1989; 46: 158-161.
19. Tokunaga A, Onda M, Taramoto T et al. Clinical significance of EGF, EGF-receptor and C-erbB-2 in human gastric cancer. Proceedings of the 1st International Gastric Cancer Congress. Bologna: Monduzzi Editore, 1995: 757-762
20. Hermanek P, Sobin LH. TNM classification of malignant tumors. 4th ed. Berlin: Springer-Verlag, 1987.
21. Lauren P. The two histologic main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand 1965; 64: 31-49.
22. Japanese Research Society for Gastric Cancer. Japanese classification of gastric carcinoma. First English Edition. Tokyo: Kanehara & Co., 1995.
23. Carlini M, Garofalo A, Rinaldi G et al. Gastric cancer cell DNA content correlates with early and late results after gastrectomy. Int Surg 1994; 79: 114-119.
24. D'Agnano I, D'Angelo C, Savarese A et al. DNA ploidy, proliferative index, epidermal growth factor receptor expression and prognosis in patients with gastric cancer. Lab Invest 1995; 72(4): 1-7.
25. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Sta Assoc 1958; 53: 457-481.
26. Breslow N. A generalized Kruskall-Wallis test for comparing K samples subjects to unequal patterns of censorship. Biometrika 1970; 57: 579-594.
27. Cox DR. Regression models and life tables. J R Stat Soc Br 1972; 34: 187-220.
28. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content on paraffin-embedded pathological material using flow-cytometry. J Histochem Cytochem 1983; 31:1333-1335.
29. Camplejohn RS, Macartney JC. Comparison of DNA flow cytometry from fresh and paraffin-embedded samples of non-Hodgkin's lymphoma. J Clin Pathol 1985; 38: 1096-1099.
30. Kallioniemi OP. Comparison of fresh and paraffin-embedded tissue as starting material for DNA flow cytometry and evaluation of intratumor heterogeneity. Cytometry 1988; 9: 164-169.
31. Lampariello F, Sebastiani G, Cordelli E, Spano M. Modeling fluorescence dispersion in flow cytometric DNA histograms. Cytometry 1991; 12:343-349.
32. de Aretxabala X, Yionemura Y, Sugiyama K et al. DNA ploidy pattern and tumor spread in gastric cancer. Br J Surg 1988; 75: 770-773.
33. Korenaga D, Okamura T, Saito A, Baba H, Sugimachi K. DNA ploidy is closely linked to tumor invasion, lymph node metastasis and prognosis in clinical gastric cancer. Cancer 1988; 62: 309-313.
34. Wyatt JI, Quirke P, Ward DC et al. Comparison of histopathological and flow cytometric parameters in prediction of prognosis in gastric cancer. J Pathol 1989; 158: 195-201.
35. Haraguchi M, Watanabe A, Moriguchi S et al. DNA ploidy is a major prognostic factor in advanced gastric carcinoma - univariate and multivariate analysis. Surgery 1991; 110: 814-819.
36. Böttger TC, Gabbert H, Stöckle TC et al. DNA image cytometry in stomach carcinoma. Cancer 1992; 70: 1819-1824.
37. Koss LG, Czerniak B, Herz F, Wersto LP. Flow cytometric measurements of DNA and other cell components on human tumors: a critical appraisal. Hum Pathol 1989; 20: 528-548.
38. Japanese Research Society for Gastric Cancer and Miwa Cancer Registry. Treatment results of gastric carcinoma in Japan (1979-1982). No. 39. Tokyo: Mitamura Press, 1995.
39. British Stomach Cancer Group. Resection line disease in stomach cancer. BMJ 1984; 289: 601-3.
40. Hallissey MT, Jewkes AJ, Dunn JA, Ward L, Fielding JWL. Resection-line involvement in gastric cancer: a continuing problem. Br J Surg 1993; 80: 1418-20.