Antiviral properties of 3-quinolinecarboxamides: A series of novel non-nucleoside antiherpetic agents

Drug Design and Discovery

Volumn 15, Issue 1, 1997, Pages 25-38

  Wentland, Mark P ^a,b   Perni, Robert B ^a   Dorff, Peter H ^a   Brundage, R Pauline ^a   Castaldi, Michael J ^a   Carlson, John A ^a   Bailey, Thomas R ^a   Aldous, Suzanne C ^a   Carabateas, Philip M ^a   Bacon, Edward R ^a   Kullnig, Rudolph K ^a   Young, Dorothy C ^a   Woods, Maureen G ^a   Kingsley, Susan D ^a   Ryan, Kathryn A ^a   Rosi, David ^a   Drozd, Marion L ^a   Dutko, Frank J ^a  

^a EASTMAN KODAK COMPANY   (United States)

^b Research Rensselaer Polytechnic Institute   (United States)

Author keywords

3 Quinolinecarboxamides; Antiviral; Herpes

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; QUINOLINE DERIVATIVE; ROSOXACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; HERPES SIMPLEX VIRUS 2; HERPES VIRUS; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; VIRUS INFECTION;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DISEASE MODELS, ANIMAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HERPESVIRUS 2, HUMAN; HUMANS; MICE; PLAQUE ASSAY; QUINOLINES; SIMPLEXVIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 8544233521     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

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7. Wentland, M. P., Perni, R. B., Dorff, P. H., Brundage, R. P., Castaldi, M. J , Bailey, T R., Carabateas, P. M., Bacon, E. R., Young, D. C., Woods, M. G., Rosi, D., Drozd, M. L., Kullnig, R. K. and Dutko, F J. (1993). 3-Quinolinecarboxamides. A Series of Novel Orally-active Antiherpetic Agents. J. Med. Chem., 36, 1580-1596.
8. Wentland, M. P., Carlson, J. A., Dorff, P. H., Aldous, S. C , Perni, R. B., Young, D. C., Woods, M. G., Kingsley, S. D., Ryan, K. A., Rosi, D., Drozd, M. L. and Dutko, F. J (1995). Cyclic Variations of 3-Quinolinecarboxamides and Effects on Antiherpetic Activity. J. Med. Chem., 38, 2541-2545.
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11. The 7-(4-pyridinyl) group imparts excellent in vivo properties to rosoxacin (see ref. 5). Also 7-(2,6-dimethyl-4-pyridinyl) quinolones have po/iv in vivo antibacterial efficacy ratios near unity: Reuman, M., Daum, S., Singh, B., Wentland, M. P., Perni, R. B., Pennock, P., Carabateas, P. M., Gruett, M. D., Saindane, M. T., Dorff, P. H., Coughlin, S. A., Sedlock, D. M., Rake, J. B. and Lesher, G. Y. (1995). Synthesis and Antibacterial Activity of some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents. J. Med. Chem., 38, 2531-2540.
12. A similar biotransformation has been reported: Chaykin, S. and Bloch, K. (1959). The Metabolism of Nicotinamide-N-oxide. Biochim. Biophys. Acta, 31, 213-216.
13. Unpublished preliminary results; Department of Virology, Sterling Winthrop Inc.