Effects of eicosapentaenoic acid on blood rheology in rats with fatty liver

Current Therapeutic Research - Clinical and Experimental

Volumn 58, Issue 8, 1997, Pages 525-532

  Kurihara, Takeshi ^a   Akimoto, Masumi ^a   Tsuchiya, Mariko ^a   Hashimoto, Hiroshi ^a   Ishiguro, Hisataka ^a   Niimi, Akiko ^a   Maeda, Atsushi ^a   Shigemoto, Mutsuo ^a   Yamashita, Katsuko ^a   Yokoyama, Izumi ^a   Kashima, Susumu ^b   Kikuchi, Yuji ^c  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b Omegawave Inc   (Japan)

^c NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

Eicosapentaenoic acid; Fatty liver; Laser Doppler flow meter; Microchannel method

Indexed keywords

ICOSAPENTAENOIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD RHEOLOGY; CONTROLLED STUDY; FATTY LIVER; HISTOPATHOLOGY; LEUKOCYTE ADHERENCE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION;

EID: 8544219704     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(97)80044-6     Document Type: Article

References (15)

1. Kurihara T, Adachi Y, Yamagata M, et al. Role of eicosapentaenoic acid in lipid metabolism in the liver, with special reference to experimental fatty liver. Clin Ther. 1994;18:263-269.
2. Kurihara T, Akimoto M, Kurokawa K, et al. ET-3 sensitive reduction of tissue blood flow in rat liver. Life Sci. 1992;51:101-106.
3. Kurihara T, Akimoto M, Kurokawa K, et al. Relationship between endothelin and thromboxane A2 in rat liver microcirculation. Life Sci. 1992;51:281-285.
4. Kikuchi Y, Sato K, Ohki H, et al. Optically accessible microchannels formed in a single-crystal silicon substrate for studies of blood cells. Microvasc Res. 1992;44:226-240.
5. Kikuchi Y, Sato K, Mizuguchi Y. Modified cell-flow microchannels formed in a single-crystal silicon substrate and flow behavior of blood cells. Microvasc Res. 1994;47:128-139.
6. Kikuchi Y. Effect of leukocytes and platelets on blood flow through a parallel array of microchannels: Micro- and macro-flow rheological measures of leukocyte and platelet activities. Microvasc Res. 1995;50:288-300.
7. Dyerberg J, Bang HO, Hjorne N. Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr. 1975;28:958-966.
8. Dyerberg J, Bang HO. Hematostatic function and platelet polyunsaturated fatty acid in Eskimos. Lancet. 1979;2:433-435.
9. Kashima S. Non-contact laser tissue blood flow measurement using polarization to reduce the specular reflection artifact. Optics Laser Technol. 1994;26:169-175.
10. Kurihara T, Izumi Y, Murao N, et al. Fatty liver case studies by ultrasonic diagnosis. J Tokyo Women's Med Coll. 1990;60:411-415.
11. Haris WS. Fish oils and plasma lipid and lipoprotein metabolism in humans: A critical review. J Lipid Res. 1989;30:785-807.
12. Needlman P, Raz A, Minkes MS, et al. Prostacyclin and thromboxane biosynthesis and unique biological properties. Proc Natl Acad Sci USA. 1979;76:944-948.
13. Fisher S, Waber PC. Thromboxane A2 is formed in human platelets after dietary eicosapentaenoic acid. Biochem Biophys Res Commun. 1983;15:1091-1099.
14. Swann PG, Venton DL, Breton GC. Eicosapentaenoic acid and docosahexaenoic acid are antagonists at the thromboxane A2/prostaglandin H2 receptor in human platelets. FEBF Lett. 1989;43:244-246.
15. Terano T, Hirai A, Hamazaki T, et al. Effect of oral administration of highly purified eicosapentaenoic acid on platelet function: Blood viscosity and red cell deformity in healthy human subjects. Atherosclerosis. 1983;48:321-331.