NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF MOLYBDENUM TRIOXIDE (CAS NO. 1313-27-5) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES)

NTP Technical Report on the Toxicology and Carcinogenesis Studies Series

Volumn TR-462, Issue , 1997, Pages 1-269

  Chan, P C ^g   Boorman, G A ^g   Bridge, D A ^g   Bucher, J R ^g   Burka, L T ^g   Hailey, J R ^c   Haseman, J K ^g   Herbert, R A ^c   Rao, G N ^g   Roycroft, J H ^g   Travlos, G S ^g   Walters, D B ^g   Witt, K L ^a   Coate, W B ^g   Alsaker, R D ^g   Tacey, R L ^g   Ulland, B M ^g   Chou, B J ^g   Greenspan, B J ^g   Mast, T J ^g   Miller, R A ^g   Hardisty, J F ^g   Wells, M ^d   Brecher, S ^g   Hildebrandt, P K ^b   Elwell, M R ^c   Radovsky, A ^c   Sills, R C ^c   Leininger, J R ^e   Torii, M ^c   Trujillo, J D ^f   Healy, L ^f   Morris, R W ^g   Mintz, N G ^g   Rosenblum, S ^g   Gunnels, S R ^g   Carlton, J R ^g   Harper, L M ^g   Serbus, D C ^g   more..

^a OAK RIDGE ASSOCIATED UNIVERSITIES   (United States)

^b PATHCO

^c National Toxicology Program

^d EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^e INTEGRATED LABORATORY SYSTEMS   (United States)

^f NORTH CAROLINA STATE UNIVERSITY   (United States)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85149246883     PISSN: 23788917     EISSN: 23788925     Source Type: Book Series    
DOI: None     Document Type: Review

References (113)

1. American Conference of Governmental Industria l Hygienists (ACGIH) (1995). 1995-1996 Threshol d Limit Values (TLVs™) for Chemical Substances and Physical Agents and Biological Exposure Indice s (BEIs™). ACGIH, Cincinnati, OH.
2. 99molybdenum after oral administration to lactating ruminants [in German, English summary]. Arch. Tierernahr. 21, 505-513.
3. Armitage, P. (1971). Statistical Methods in Medical Research, pp. 362-365. John Wiley and Sons, Inc., New York.
4. Arrington, L.R., and Davis, G.K. (1953). Molyb denum toxicity in the rabbit. J. Nutr. 51, 295-304.
5. Ashby, J., and Tennant, R.W. (1991). Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat. Res. 257, 229-306.
6. Babaian, E.A., Bagramian, S.B., and Pogosian, A.S. (1980). Effect of some chemical hazards involved in molybdenum production on the chromosome apparatus of experimental animals and of man [in Russian]. Gig. Tr. Prof. Zabol. 9, 33-36.
7. Bela, Y.M., and Lifshits, V.M. (1966). Contents of trace elements in the blood of leukemia and anemia. Fed. Proc. Transl. Suppl. 25, 370-372.
8. Bompart, G., Pécher, C., Prévot, D., an d Girolami, J.-P. (1990). Mild renal failure induced by subchronic exposure to molybdenum: urinary kallikrein excretion as a marker of distal tubular effect. Toxicol. Lett. 52, 293-300.
9. Boorman, G.A., Montgomery, C.A., Jr., Eustis, S.L., Wolfe, M.J., McConnell, E.E., and Hardisty, J.F. (1985). Quality assurance in pathology for rodent carcinogenicity studies. In Handbook of Carcinogen Testing (H.A. Milman and E.K. Weisburger, Eds.), pp. 345-357. Noyes Publications, Park Ridge, NJ.
10. Bruin, A. De. (1976). In Biochemical Toxicology of Environmental Agents, pp. 460-461. Elsevier/North-Holland Biochemical Press, Amsterdam.
11. Burrell, R.J.W., Roach, W.A., and Shadwell, A. (1966). Esophageal cancer in the Bantu of the Transkei associated with mineral deficiency in garden plants. J. Natl. Cancer Inst. 36, 201-214.
12. Code of Federal Regulations (CFR) 21, Part 58.
13. 2. Proc. Acad. Sci. 70, 3655-3659.
14. Cox, D.R. (1972). Regression models and life-tables. J. R. Stat. Soc. B34, 187-220.
15. Crawford, B.D. (1985). Perspectives on the somati c mutation model of carcinogenesis. In Advances in Modern Environmental Toxicology : Mechanisms and Toxicity of Chemical Carcinogens and Mutagens (M.A. Mehlman, W.G. Flamm, and R.J. Lorentzen, Eds.), pp. 13-59. Princeton Scientific Publishing Co. Inc., Princeton, NJ.
16. Davis, G.K. (1950). The influence of copper on the metabolism of phosphorus and molybdenum. In Copper Metabolism: A Symposium on Animal, Plant and Soil Relationships (W.D. McElroy and B. Glass, Eds.), pp. 216-229. The Johns Hopkins Press, Baltimore.
17. Deosthale, Y.G., and Gopalan, C. (1974). The effect of molybdenum levels in sorghum (Sorghum vulgare Pers.) on uric acid and copper excretion in man. Br. J. Nutr. 31, 351-355.
18. De Renzo, E.C. (1962). Molybdenum. In Mineral Metabolism: An Advanced Treatise (C.L. Comar and F. Bronner, Eds.), Vol. II, Part B, pp. 483-498. Academic Press, New York.
19. Dick, A.T., Dewey, D.W., and Gawthorne, J.M. (1975). Thiomolybdates and the copper-molybdenumsulphur interaction in ruminant nutrition. J. Agric. Sci. 85, 567-568.
20. Dinse, G.E., and Haseman, J.K. (1986). Logistic regression analysis of incidentaltumor data from animal carcinogenicity experiments. Fundam. Appl. Toxicol. 6, 44-52.
21. Dinse, G.E., and Lagakos, S.W. (1983). Regression analysis of tumour prevalence data. Appl. Statist. 32, 236-248.
22. Dixon, W.J., and Massey, F.J., Jr. (1951). Introduction to Statistical Analysis, 1st ed., pp. 145-147. McGraw-Hill Book Company, New York.
23. Dunn, O.J. (1964). Multiple comparisons using rank sums. Technometrics 6, 241-252.
24. Dunnett, C.W. (1955). A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50, 1096-1121.
25. Fairhall, L.T., Dunn, R.C., Sharpless, N.E., and Pritchard, E.A. (1945). The toxicity of molybdenum. U.S. Public Health Bull. 293, 1-36.
26. Friberg, L. (1979). Molybdenum. In Handbook on the Toxicology of Metals (L. Friberg, G.F. Nordberg, and V.B. Vouk, Eds.), pp. 531-539. Elsevier/North - Holland Biomedical Press, Amsterdam.
27. Fried, R., Fried, L.W., and Babin, D.R. (1973). Biological role of xanthine oxidase and tetrazolium reductase inhibitor. Eur. J. Biochem. 33, 439-445.
28. Galloway, S.M., Armstrong, M.J., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A.D., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B.H., Resnick, M.A., Anderson, B., an d Zeiger, E. (1987). Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Mol. Mutagen. 10 (Suppl. 10), 1-175.
29. Gart, J.J., Chu, K.C., and Tarone, R.E. (1979). Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. JNCI 62, 957-974.
30. Gould, E.S. (1962). Inorganic Reactions and Structure, pp. 331-332. Holt, Rinehart and Winston, Inc., New York.
31. Goyer, R.A. (1991). Toxic effects of metals. In Casarett and Doull's Toxicology: The Basic Science of Poisons (M.O. Amdur, J. Doull, and C.D. Klaassen, Eds.), 4thed., pp. 623-680. Pergamon Press, New York.
32. Halverson, A.W., Phifer, J.H., and Monty, K.J. (1960). A mechanism for the copper-molybdenum interrelationship. J. Nutr. 71, 95-100.
33. Hammond, P.B., and Beliles, R.P. (1980). Metals. In Casarett and Doull's Toxicology: The Basic Science of Poisons (J. Doull, C.D. Klaassen, and M.O. Amdur, Eds.), 2nd ed., pp. 409-467. Macmillan Publishing Co., Inc., New York.
34. Hanafi, Z.M., Khilla, M.A., and Abu-El Saud, A. (1975). Infrared measurements on molybdenum trioxide and its suboxides. Rev. Chimie Minerale 12, 546-552.
35. Haseman, J.K. (1984). Statistical issues in the design, analysis and interpretation of animal carcino-genicity studies. Environ. Health Perspect. 58, 385-392.
36. Hazard Information Review (1981). Molybdenum (VI) Oxide, EPA TSCA Interagency Testing Committee. Prepared by Enviro Control, Rockville, MD, May 31, 1981.
37. Hollander, M., and Wolfe, D.A. (1973). Nonparametric Statistical Methods, pp. 120-123. John Wiley and Sons, New York.
38. Huber, J.T., Price, N.O., and Engel, R.W. (1971). Response of lactating dairy cows to high levels of dietary molybdenum. J. Anim. Sci. 32, 364-367.
39. Jeter, M.A., and Davis, G.K. (1954). The effect of dietary molybdenum upon growth, hemoglobin, reproduction and lactation of rats. J. Nutr. 54, 215-220.
40. Jonckheere, A.R. (1954). A distribution-free k-sample test against ordered alternatives. Biometrika 41, 133145.
41. Kada, T., Hirano, K., and Shirasu, Y. (1980). Screening of environmental chemical mutagens by the rec-assay system with Bacillus subtilis. In Chemical Mutagens: Principles and Methods for Their Detection (F.J. de Serres and A. Hollaender, Eds.), Vol. 6, pp. 149-173. Plenum Press, New York.
42. Kaplan, E.L., and Meier, P. (1958). Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53, 457-481.
43. Kirk-Othmer Encyclopedia of Chemical Technology (1981). Molybdenum and molybdenum alloys. 3rd ed., Vol. 15, pp. 670-685. John Wiley and Sons, New York.
44. Koizumi, T., Tajima, K., Emi, N., Hara, A., and Suzuki, K.T. (1995). Suppressive effect of molyb denum on hepatotoxicity of N-nitrosodiethylamine in rats. Biol. Pharm. Bull. 18, 460-462.
45. Komada, H., Kise, Y., Nakagawa, M., Yamamura, M., Hioki, K., and Yamamoto, M. (1990). Effect of dietary molybdenum on esophageal carcinogenesis in rats induced by N-methyl-N-benzylnitrosamine. Cancer Res. 50, 2418-2422.
46. Köpf-Maier, P, Leitner, M., Voigtländer, R., and Köpf, H. (1979). Molybdocene dichloride as an antitumor agent [in German, English summary]. Z. Naturforsch. 34c, 1174-1176.
47. Lalich, J.J., Groupner, K., and Jolin, J. (1965). The influence of copper and molybdate salts on the production of bony deformities in rats. Lab. Invest. 14, 1482-1493.
48. Lee, K.P. (1989). Lung response to particulates. In Encyclopedia of Environmental Control Technology: Air Pollution Control, Vol. 2, pp. 835-882. Gulf Publishing. Co., Houston.
49. Lewis, A.H. (1943). The teart pastures of Somerset. II. Relation between soil and teartness. J. Agric. Sci. 33, 52-59.
50. 1 in the tissues and urine of chronic poisoning experiment with inhalation administration of molybdenum [in Russian]. Tr. Inst. Kraev. Patol. 22, 152-154.
51. Lukashev, A.A., and Shishkova, H.K. (1971b). State of phosphatase activity and phosphorus content in animal tissues in a chronic experiment with inhalation molybdenum poisoning [in Russian]. Tr. Inst. Kraev. Patol. 22, 175-180.
52. Lukashev, A.A., and Shishkova, H.K. (1971c). Nonspecific indexes for rabbits and rats in a chronic poisoning experiment with molybdenum [in Russian]. Tr. Inst. Kraev. Patol. 22, 191-196.
53. Luo, X.-M., Wei, H.-J., and Yang, S.P. (1983). Inhibitory effects of molybdenum on esophageal and forestomach carcinogenesis in rats. JNCI 71, 75-80.
54. McConnell, E.E., Solleveld, H.A., Swenberg, J.A., and Boorman, G.A. (1986). Guidelines for combining neoplasms for evaluation of rodent carcinogenesi s studies. JNCI 76, 283-289.
55. McCord, J.M. (1985). Oxygen-d erived free radicals in postischemic tissue injury. N. Engl. J. Med. 312, 159-163.
56. McKnight, B., and Crowley, J. (1984). Tests for differences in tumor incidence based on animal carcinogenesis experiments. J. Am. Stat. Assoc. 79, 639-648.
57. Maltoni, C. (1976a). Predictive value of carcino genesis bioassays. Ann. N.Y. Acad. Sci. 271, 431-443.
58. Maltoni, C. (1976b). Precursor lesions in exposed populations as indicators of occupational cancer risk. Ann. N.Y. Acad. Sci. 271, 444-447.
59. Marcilese, N.A., Ammerman, C.B., Valsecchi, R.M., Dunavant, B.G., and Davis, G.K. (1969). Effect of dietary molybdenum and sulfate upon copper metabolism in sheep. J. Nutr. 99, 177-183.
60. Maronpot, R.R., and Boorman, G.A. (1982). Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assess ment. Toxicol. Pathol. 10, 71-80.
61. The Merck Index (1989). 11th ed. (S. Budavari, Ed.). Merck and Company, Rahway, NJ.
62. Miller, J.A., and Miller, E.C. (1977). Ultimate chemical carcinogens as reactive mutagenic electrophiles. In Origins of Human Cancer (H.H. Hiatt, J.D. Watson, and J.A. Winsten, Eds.), pp. 605-627. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
63. Miller, R.F., and Engel, R.W. (1960). Interrelations of copper, molybdenum and sulfate sulfur in nutrition. Fed. Proc. 19, 666-677.
64. Miller, R.F., Price, N.O., and Engel, R.W. (1956). Added dietary inorganic sulfa te and its effect upon rats fed molybdenum. J. Nutr. 60, 539-547.
65. Mills, C.F., and Davis, G.K. (1987). Molydenum. In Trace Elements in Human and Animal Nutrition (W. Mertz, Ed.), 5thed., Vol. 1, pp. 429-463. Academic Press, Inc., San Diego.
66. Mills, C.F., and Fell, B.F. (1960). Demyelination in lambs born of ewes maintained on high intakes of sulphate and molybdate. Nature 185, 20-22.
67. Mills, C.F., Monty, K.J., Ichihara, A., and Pearson, P.B. (1958). Metabolic effects of molyb denum toxicity in the rat. J. Nutr. 65, 129-142.
68. Milvy, P., and Kay, K. (1978). Mutagenicity of 19 major graphic arts and printing dyes. J. Toxicol. Environ. Health 4, 31-36.
69. National Cancer Institute (NCI) (1976). Guideline s for Carcinogen Bioassay in Small Rodents. Technical Report Series No. 1. NIH Publication No. 76-801. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Bethesda, MD.
70. National Institute for Occupational Safety and Health (NIOSH) (1990). National Occupational Exposure Survey (1981-1983), unpublished provisional data as of July 1, 1990. NIOSH, Cincinnati, OH.
71. National Institute for Occupational Safety and Health/Occupational Safety and Health Administration (NIOSH/OSHA) (1981). Occupational Health Guidelines for Chemical Hazards. DHHS (NIOSH) Publication No. 81-123. U.S. Department of Health and Human Services. U.S. Department of Labor.
72. National Institutes of Health (NIH) (1978). Open Formula Rat and Mouse Ration (NIH-07). Specification NIH-11-1335. U.S. Department of Health, Education, and Welfare, Public Health Service, Na tional Institutes of Health, Bethesda, MD.
73. National Research Council (1980). Recommended Dietary Allowances. 9thed. National Academy of Sciences, Washington, DC.
74. National Toxicology Program (NT P) (1983). National Toxicology Program General Statement of Work. Technical Proposal for Sperm Morphology and Vaginal Cytology Evaluation in Toxicity Testing for Rats and mice, 10/31/82 version (updated October 1983). Research Triangle Park, NC.
75. 1 Mice (Inhalation Studies). Technica l Report Series No. 421. NIH Publication No. 93-3152. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC.
76. 1 Mice (Inhalation Studies). Technical Report Series No. 451. NIH Publication No. 96-3363. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC.
77. 1 Mice (Inhalation Studies). Technical Report Series No. 453. NIH Publication No. 96-3369. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC.
78. Nederbragt, H. (1982). Changes in the distribution of copper and molybdenum after Mo administration and subsequent additional oral or intraperitoneal C u administration to rats. Br. J. Nutr. 48, 353-364.
79. Neilands, J.B., Strong, F.M., and Elvehjem, C.A. (1948). Molybdenum in the nutrition of the rat. J. Biol. Chem. 172, 431-439.
80. Nemenko, B.A., Moldakulova, M.M., and Zorina, S.N. (1976). Rasprostranenie rak a pishchevoda V Gur'evskoi blasti v zavisimosti ot mineral'nogo sostava pit'evoivody [in Russian]. Vopr. Onkol. 22, 75-76.
81. Nyquist, R.A. (1971). Spectrum No. 352. In Infrared Spectra of Inorganic Compounds, pp. 224-225, Academic Press, Inc., New York.
82. Ostrom, C.A., Van Reen, R., and Miller, C.W. (1961). Changes in the connective tissue of rats fed toxic diets containing molybdenum salts. J. Dent. Res. 40, 520528.
83. Patty's Industrial Hygiene and Toxicology (1981). (G.D. Clayton and F.E. Clayton, Eds.), 3rd rev. ed., Vol. 2A, pp. 1493-2060. John Wiley and Sons, New York.
84. Pitt, M.A. (1976). Molybdenum toxicity: Inter actions between copper, molybdenum and sulphate. Agents Actions 6, 758-769.
85. Pitt, M., Fraser, J., and Thurley, D.C. (1980). Molybdenum toxicity in sheep: Epiphysiolysis, exotoses and biochemical changes. J. Comp. Pathol. 90, 567-576.
86. Ridgway, L.P., and Karnofsky, D.A. (1952). The effects of metals on the chick embryo: Toxicity and production of abnormalities in deve lopment. Ann. N.Y. Acad. Sci. 55, 203-215.
87. Robinson, J.B.D., and Clifford, P. (1968). Trace element levels and carcinoma of the nasopharynx in Kenya. East Afr. Med. J. 45, 694-700.
88. Sax, N.I. (1984). Dangerous Properties of Industrial Materials, 6thed. Van Nostrand Rei nhold, New York.
89. Schroeder, H.A., and Mitchener, M. (1971). Toxic effects of trace elements on the reproduction of mice and rats. Arch. Environ. Health 23, 102-106.
90. Seaborn, C.D., and Yang, S.P. (1993). Effect of molybdenum supplementation on N-nitrosoN-methylurea-induced mammary carcinogenesis and molybdenum excretion in rats. Biol. Trace Elem. Res. 39, 245-256.
91. Shirley, E. (1977). A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment. Biometrics 33, 386-389.
92. 45 in swine. J. Nutr. 54, 59-64.
93. Sittig, M. (1994). World-Wide Limits for Toxic and Hazardous Chemicals in Air, Water and Soil, pp. 527-528. Noyes Publications, Park Ridge, NJ.
94. Spence, J.A., Suttle, N.F., Wenham, G., El-Gallad, T., and Bremner, I. (1980). A sequential study of the skeletal abnormalities which develop in rats given a small dietary supplement of ammonium tetrathiomolybdate. J. Comp. Pathol. 90, 139-153.
95. Stoner, G.D., Shimkin, M.B., Troxell, M.C., Thompson, T.L., and Terry, L.S. (1976). Test for carcinogenicity of metallic compounds by the pulmonary tumor response in strain A mice. Cancer Res. 36, 1744-1747.
96. Straus, D.S. (1981). Somatic mutation, cellular differentiation, and cancer causation. JNCI 67, 233.
97. Suttle, N.F. (1974). Recent studies of the copper molybdenum antagonism. Proc. Nutr. Soc. 33, 299-305.
98. Tarone, R.E. (1975). Tests for trend in life table analysis. Biometrika 62, 679-682.
99. Tennant, R.W., Margolin, B.H., Shelby, M.D., Zeiger, E., Haseman, J.K., Spalding, J., Caspary, W., Resnick, M., Stasiewicz, S., Anderson, B., and Minor, R. (1987). Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. Science 236, 933-941.
100. Thomas, J.W., and Moss, S. (1951). The effect of orally administered molybdenum on growth, sper matogenesis and testes histology of young dairy bulls. J. Dairy Sci. 34, 929-934.
101. U.S. Environmental Protection Agency (USEPA) (1975). Molybdenum - A toxicological appraisal: EPA-600/1-75-004. Health Effects Research Laboratory, Office of Research and Development, Research Triangle Park, NC.
102. Van Gennip, A.H., Abeling, N.G.G.M., Stroomer, A.E.M., Overmars, H., and Bakker, H.D. (1994). The detection of molybdenum cofactor deficiency: Clinical symptomatology and urinary metabolite profile. J. Inherit. Metab. Dis. 17, 142-145.
103. Van Reen, R. (1959). The specificity of the molybdate-sulfate interrelationship in rats. J. Nutr. 68, 243-250.
104. Venitt, S., and Levy, L.S. (1974). Mutagenicity of chromates in bacteria and its relevance to chromate carcinogenesis. Nature 250, 493-495.
105. Venugopal, B., and Luckey, T.D. (1978). Metal Toxicity in Mammals • 2. Chemical Toxicity of Metals and Metalloids. Plenum Press, New York.
106. Walravens, P.A., Moure-Eraso, R., Solomons, C.C., Chappell, W.R., and Bentley, G. (1979). Biochemical abnormalities in workers exposed to molybdenu m dust. Arch. Environ. Health 34, 302-307.
107. Weast, R.C., Ed. (1989). CRC Handbook of Chemistry and Physics, 70th ed., p. B-108. CRC Press, Inc., Boca Raton, FL.
108. Wei, H.-J., Luo, X.-M., and Yang, S.P. (1985). Effects of molybdenum and tungsten on mammary carcinogenesis in SD rats. JNCI 74, 469-473.
109. Williams, D.A. (1971). A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 27, 103-117.
110. Williams, D.A. (1972). The comparison of several dose levels with a zero dose control. Biometrics 28, 519-531.
111. Xin, Z., Silvia, W.J., Waterman, D.F., Hemken, R.W., and Tucker, W.B. (1993). Effect of copper status on luteinizing hormone secretion in dairy steers. J. Dairy Sci. 76, 437-444.
112. Zeiger, E., Haseman, J.K., Shelby, M.D., Margolin, B.H., and Tennant, R.W. (1990). Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicals. Environ. Mol. Mutagen. 16 (Suppl. 18), 1-14.
113. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. (1992). Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ. Mol. Mutagen. 19 (Suppl. 21), 2-141.