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Volumn TR-491, Issue , 2000, Pages 1-420

NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYLEUGENOL (CAS NO. 93-15-2) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES)

(47)  Abdo, K M a   Blumenthal, G M a   Bridge, D A a   Bucher, J R a   Chapin, R E a   Haseman, J K a   Maronpot, R R a   Rao, G N a   Roycroft, J H a   Smith, C S a   Travlos, G S a   Witt, K L a   Prejean, J D a   Manus, A G a   Thompson, R B a   Hejtmancik, M R a   Johnson, J D a   Hardisty, J F a   Gaillard, E T a,c   Morris, R W a   more..


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EID: 85149207941     PISSN: 23788917     EISSN: 23788925     Source Type: Book Series    
DOI: None     Document Type: Review
Times cited : (25)

References (118)
  • 1
    • 0023203552 scopus 로고
    • Hepatoblastoma: An immunohistochemical and ultrastructural study
    • Abenoza, P., Manivel, J.C., Wick, M.R., Hagen, K., and Dehner, L.P. (1987). Hepatoblastoma: An immunohistochemical and ultrastructural study. Hum. Pathol. 18, 1025-1035.
    • (1987) Hum. Pathol , vol.18 , pp. 1025-1035
    • Abenoza, P.1    Manivel, J.C.2    Wick, M.R.3    Hagen, K.4    Dehner, L.P.5
  • 2
    • 0026751937 scopus 로고
    • Evaluation in a battery of in vivo assays of four in vitro genotoxins proved to be noncarcinogens in rodents
    • Allavena, A., Martelli, A., Robbiano, L., and Brambilla, G. (1992). Evaluation in a battery of in vivo assays of four in vitro genotoxins proved to be noncarcinogens in rodents. Teratog. Carcinog. Mutagen. 12, 31-41.
    • (1992) Teratog. Carcinog. Mutagen , vol.12 , pp. 31-41
    • Allavena, A.1    Martelli, A.2    Robbiano, L.3    Brambilla, G.4
  • 3
    • 0000973407 scopus 로고
    • Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP
    • Ashby, J., and Tennant, R.W. (1991). Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP. Mutat. Res. 257, 229-306.
    • (1991) Mutat. Res , vol.257 , pp. 229-306
    • Ashby, J.1    Tennant, R.W.2
  • 4
    • 0023677290 scopus 로고
    • Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples
    • Bailer, A.J., and Portier, C.J. (1988). Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44, 417-431.
    • (1988) Biometrics , vol.44 , pp. 417-431
    • Bailer, A.J.1    Portier, C.J.2
  • 8
    • 0027433159 scopus 로고
    • Ratio of estimates, the delta method, and quantal response tests for increased carcinogenicity
    • Bieler, G.S., and Williams, R.L. (1993). Ratio of estimates, the delta method, and quantal response tests for increased carcinogenicity. Biometrics 49, 793-801.
    • (1993) Biometrics , vol.49 , pp. 793-801
    • Bieler, G.S.1    Williams, R.L.2
  • 9
    • 0021054404 scopus 로고
    • Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1N-sulfoxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1N-hydroxysafrole in mouse liver
    • Boberg, E.W., Miller, E.C., Miller, J.A., Poland, A., and Liem, A. (1983). Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1N-sulfoxysafrole is the major ultimate electrophilic and carcinogenic metabolite of 1N-hydroxysafrole in mouse liver. Cancer Res. 43, 5163-5173.
    • (1983) Cancer Res , vol.43 , pp. 5163-5173
    • Boberg, E.W.1    Miller, E.C.2    Miller, J.A.3    Poland, A.4    Liem, A.5
  • 10
    • 0000905316 scopus 로고
    • Quality assurance in pathology for rodent carcinogenicity studies
    • (H.A. Milman and E.K. Weisburger, Eds), Noyes Publications, Park Ridge, NJ
    • Boorman, G.A., Montgomery, C.A., Jr., Eustis, S.L., Wolfe, M.J., McConnell, E.E., and Hardisty, J.F. (1985). Quality assurance in pathology for rodent carcinogenicity studies. In Handbook of Carcinogen Testing (H.A. Milman and E.K. Weisburger, Eds.), pp. 345-357. Noyes Publications, Park Ridge, NJ.
    • (1985) Handbook of Carcinogen Testing , pp. 345-357
    • Boorman, G.A.1    Montgomery, C.A.2    Eustis, S.L.3    Wolfe, M.J.4    McConnell, E.E.5    Hardisty, J.F.6
  • 11
    • 0015593170 scopus 로고
    • The metabolism of the naturally occurring hepatocarcinogen safrole to 1N-hydroxy-safrole and the electrophilic reactivity of 1N-acetoxy-safrole
    • Borchert, P., Wislocki, P.G., Miller, J.A., and Miller, E.C. (1973). The metabolism of the naturally occurring hepatocarcinogen safrole to 1N-hydroxy-safrole and the electrophilic reactivity of 1N-acetoxy-safrole. Cancer Res. 33, 575-589.
    • (1973) Cancer Res , vol.33 , pp. 575-589
    • Borchert, P.1    Wislocki, P.G.2    Miller, J.A.3    Miller, E.C.4
  • 12
    • 0030581287 scopus 로고    scopus 로고
    • Saturated and monofluoro analogs of the oriental fruit fly attractant methyl eugenol show reduced genotoxic activities in yeast
    • Brennan, R.J., Kandikonda, S., Khrimian, A.P., DeMilo, A.B., Liquido, N.J., and Schiestl, R.H. (1996). Saturated and monofluoro analogs of the oriental fruit fly attractant methyl eugenol show reduced genotoxic activities in yeast. Mutat. Res. 369, 175-181.
    • (1996) Mutat. Res , vol.369 , pp. 175-181
    • Brennan, R.J.1    Kandikonda, S.2    Khrimian, A.P.3    DeMilo, A.B.4    Liquido, N.J.5    Schiestl, R.H.6
  • 13
    • 0019414429 scopus 로고
    • Methyleugenol as a surgical anesthetic in rodents
    • Carlini, E.A., Dallmeier, K., and Zelger, J.L. (1981). Methyleugenol as a surgical anesthetic in rodents. Experientia 37, 588-589.
    • (1981) Experientia , vol.37 , pp. 588-589
    • Carlini, E.A.1    Dallmeier, K.2    Zelger, J.L.3
  • 14
    • 0020801855 scopus 로고
    • Psychopharmacological effects of the essential oil fraction and of the hydrolate obtained from the seeds of Licaria puchury-major
    • Carlini, E.A., de Oliveira, A.B., and de Oliveira, G.G. (1983). Psychopharmacological effects of the essential oil fraction and of the hydrolate obtained from the seeds of Licaria puchury-major. J. Ethnopharmacol. 8, 225-236.
    • (1983) J. Ethnopharmacol , vol.8 , pp. 225-236
    • Carlini, E.A.1    de Oliveira, A.B.2    de Oliveira, G.G.3
  • 15
    • 0026459531 scopus 로고
    • Comparative induction of unscheduled DNA synthesis in cultured rat hepatocytes by allylbenzenes and their 1N-hydroxy metabolites
    • Chan, V.S.W., and Caldwell, J. (1992). Comparative induction of unscheduled DNA synthesis in cultured rat hepatocytes by allylbenzenes and their 1N-hydroxy metabolites. Food Chem. Toxicol. 30, 831-836.
    • (1992) Food Chem. Toxicol , vol.30 , pp. 831-836
    • Chan, V.S.W.1    Caldwell, J.2
  • 18
    • 85149236529 scopus 로고
    • Natural flavoring substances, their sources, and additional artificial flavoring substances
    • Strasbourg, France
    • Council of Europe (1974). Natural flavoring substances, their sources, and additional artificial flavoring substances. Partial agreement in the social and public health field, List 1, No. 185. Strasbourg, France.
    • (1974) Partial agreement in the social and public health field, List 1, No. 185
  • 19
    • 0000336139 scopus 로고
    • Regression models and life-tables
    • Cox, D.R. (1972). Regression models and life-tables. J. R. Stat. Soc. B34, 187-220.
    • (1972) J. R. Stat. Soc , vol.B34 , pp. 187-220
    • Cox, D.R.1
  • 20
    • 10544229036 scopus 로고
    • Perspectives on the somatic mutation model of carcinogenesis
    • (M.A. Mehlman, W.G. Flamm, and R.J. Lorentzen, Eds), Princeton Scientific Publishing Co., Inc., Princeton, NJ
    • Crawford, B.D. (1985). Perspectives on the somatic mutation model of carcinogenesis. In Advances in Modern Environmental Toxicology. Mechanisms and Toxicity of Chemical Carcinogens and Mutagens (M.A. Mehlman, W.G. Flamm, and R.J. Lorentzen, Eds.), pp. 13-59. Princeton Scientific Publishing Co., Inc., Princeton, NJ.
    • (1985) Advances in Modern Environmental Toxicology. Mechanisms and Toxicity of Chemical Carcinogens and Mutagens , pp. 13-59
    • Crawford, B.D.1
  • 21
    • 0019364985 scopus 로고
    • Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues
    • Dallmeier, K., and Carlini, E.A. (1981). Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacology 22, 113-127.
    • (1981) Pharmacology , vol.22 , pp. 113-127
    • Dallmeier, K.1    Carlini, E.A.2
  • 22
    • 85149211959 scopus 로고
    • Offen. Patent No. 2719623, 18/08/1977
    • Deininger, R., and Wolfe, E. (1977) Germ. Offen. Patent No. 2719623, 18/08/1977.
    • (1977) Germ
    • Deininger, R.1    Wolfe, E.2
  • 24
    • 0019210482 scopus 로고
    • Biotransformation of allylbenzene analogues in vivo and in vitro through the epoxidediol pathway
    • Delaforge, M., Janiaud, P., Levi, P., and Morizot, J.P. (1980a). Biotransformation of allylbenzene analogues in vivo and in vitro through the epoxidediol pathway. Xenobiotica 10, 737-744.
    • (1980) Xenobiotica , vol.10 , pp. 737-744
    • Delaforge, M.1    Janiaud, P.2    Levi, P.3    Morizot, J.P.4
  • 26
    • 0033584421 scopus 로고    scopus 로고
    • Mutation of $-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis
    • Devereux, T.R., Anna, C.H., Foley, J.F., White, C.M., Sills, R.C., and Barrett, J.C. (1999). Mutation of $-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis. Oncogene 18, 4726-4733.
    • (1999) Oncogene , vol.18 , pp. 4726-4733
    • Devereux, T.R.1    Anna, C.H.2    Foley, J.F.3    White, C.M.4    Sills, R.C.5    Barrett, J.C.6
  • 28
    • 84861604521 scopus 로고
    • Multiple comparisons using rank sums
    • Dunn, O.J. (1964). Multiple comparisons using rank sums. Technometrics 6, 241-252.
    • (1964) Technometrics , vol.6 , pp. 241-252
    • Dunn, O.J.1
  • 29
    • 0009663357 scopus 로고
    • A multiple comparison procedure for comparing several treatments with a control
    • Dunnett, C.W. (1955). A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50, 1096-1121.
    • (1955) J. Am. Stat. Assoc , vol.50 , pp. 1096-1121
    • Dunnett, C.W.1
  • 30
    • 0028122926 scopus 로고
    • Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse
    • Factor, V.M., Radaeva, S.A., and Thorgeirsson, S.S. (1994). Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am. J. Pathol. 145, 409-422.
    • (1994) Am. J. Pathol , vol.145 , pp. 409-422
    • Factor, V.M.1    Radaeva, S.A.2    Thorgeirsson, S.S.3
  • 31
    • 0003561244 scopus 로고
    • Meister Publishing Co., Willoughby, Ohio
    • Farm Chemical Handbook (1992). Meister Publishing Co., p. C221, Willoughby, Ohio.
    • (1992) Farm Chemical Handbook , pp. C221
  • 32
    • 84873343355 scopus 로고
    • 2nd ed., (T.E. Furia and N. Bellanca, Eds), The Chemical Rubber Co., Cleveland, Ohio
    • Fenaroli's Handbook of Flavor Ingredients (1975). 2nd ed., Vol. 2 (T.E. Furia and N. Bellanca, Eds.), p. 200. The Chemical Rubber Co., Cleveland, Ohio.
    • (1975) Fenaroli's Handbook of Flavor Ingredients , vol.2 , pp. 200
  • 33
    • 0021173863 scopus 로고
    • Characterization of the biliary and urinary glutathione and N-acetylcysteine metabolites of the hepatic carcinogen 1N-hydroxysafrole and its 1N-oxo metabolite in rats and mice
    • Fennell, T.R., Miller, J.A., and Miller, E.C. (1984). Characterization of the biliary and urinary glutathione and N-acetylcysteine metabolites of the hepatic carcinogen 1N-hydroxysafrole and its 1N-oxo metabolite in rats and mice. Cancer Res. 44, 3231-3240.
    • (1984) Cancer Res , vol.44 , pp. 3231-3240
    • Fennell, T.R.1    Miller, J.A.2    Miller, E.C.3
  • 34
    • 85149254515 scopus 로고
    • Accessio PB 283-501, National Technical Information Service, U.S. Department of Commerce, Washington, DC
    • Flavor and Extract Manufacturers Association of the United States (FEMA) (1978). Scientific Literature Review of Eugenol and Related Substances in Flavor Usage. Vol. 1, Accession No. PB 283-501, National Technical Information Service, U.S. Department of Commerce, Washington, DC.
    • (1978) Scientific Literature Review of Eugenol and Related Substances in Flavor Usage , vol.1
  • 35
    • 0028280185 scopus 로고
    • Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program
    • Foureman, P., Mason, J.M., Valencia, R., and Zimmering, S. (1994). Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Mol. Mutagen. 23, 51-63.
    • (1994) Environ. Mol. Mutagen , vol.23 , pp. 51-63
    • Foureman, P.1    Mason, J.M.2    Valencia, R.3    Zimmering, S.4
  • 36
    • 85149230973 scopus 로고    scopus 로고
    • Role of Helicobacter hepaticus in confounding results of a triethanolamine carcinogenesis study in mice
    • (in press)
    • Fox, J.G., MacGregor, J., Shen, Z., Li, X., Lewis, R., and Dangler, C.A. (1999). Role of Helicobacter hepaticus in confounding results of a triethanolamine carcinogenesis study in mice. J. Clin. Microbiol. (in press)
    • (1999) J. Clin. Microbiol
    • Fox, J.G.1    MacGregor, J.2    Shen, Z.3    Li, X.4    Lewis, R.5    Dangler, C.A.6
  • 38
    • 0029897470 scopus 로고    scopus 로고
    • Immunochemical detection of covalently modified protein adducts in livers of rats treated with methyleugenol
    • Gardner, I., Bergin, P., Stening, P., Kenna, J.G., and Caldwell, J. (1996). Immunochemical detection of covalently modified protein adducts in livers of rats treated with methyleugenol. Chem. Res. Toxicol. 9, 713-721.
    • (1996) Chem. Res. Toxicol , vol.9 , pp. 713-721
    • Gardner, I.1    Bergin, P.2    Stening, P.3    Kenna, J.G.4    Caldwell, J.5
  • 39
    • 0031410088 scopus 로고    scopus 로고
    • Cytochrome P450 mediated bio-activation of methyleugenol to 1N-hydroxy-methyl-eugenol in Fischer rat and human liver microsomes
    • Gardner, I., Wakazono, H., Bergin, P., de Waziers, I., Beaune, P., Kenna, J.G., and Caldwell, J. (1997). Cytochrome P450 mediated bio-activation of methyleugenol to 1N-hydroxy-methyl-eugenol in Fischer rat and human liver microsomes. Carcinogenesis 18, 1775-1783.
    • (1997) Carcinogenesis , vol.18 , pp. 1775-1783
    • Gardner, I.1    Wakazono, H.2    Bergin, P.3    de Waziers, I.4    Beaune, P.5    Kenna, J.G.6    Caldwell, J.7
  • 40
    • 0018761565 scopus 로고
    • Statistical issues in interpretation of chronic bioassay tests for carcinogenicity
    • Gart, J.J., Chu, K.C., and Tarone, R.E. (1979). Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. JNCI 62, 957-974.
    • (1979) JNCI , vol.62 , pp. 957-974
    • Gart, J.J.1    Chu, K.C.2    Tarone, R.E.3
  • 41
    • 0001697903 scopus 로고    scopus 로고
    • Secretory function of the alimentary tract
    • W.B. Saunders Company, Philadelphia, PA
    • Guyton, A.C., and Hall, J.E. (1997). Secretory function of the alimentary tract. In Human Physiology and Mechanisms of Disease, pp. 524-535. W.B. Saunders Company, Philadelphia, PA.
    • (1997) Human Physiology and Mechanisms of Disease , pp. 524-535
    • Guyton, A.C.1    Hall, J.E.2
  • 44
    • 0023729293 scopus 로고
    • Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals
    • Hayashi, M., Kishi, M., Sofuni, T., and Ishidate, M., Jr. (1988). Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals. Food Chem. Toxicol. 26, 487-500.
    • (1988) Food Chem. Toxicol , vol.26 , pp. 487-500
    • Hayashi, M.1    Kishi, M.2    Sofuni, T.3    Ishidate, M.4
  • 45
    • 80052478208 scopus 로고
    • Eds. Academic Press, Inc., San Diego
    • Hays, W.J., Jr., and Laws, E.R., Jr., Eds. (1991). Handbook of Pesticides Toxicology, Vol. 2, pp. 613-614. Academic Press, Inc., San Diego.
    • (1991) Handbook of Pesticides Toxicology , vol.2 , pp. 613-614
    • Hays, W.J.1    Laws, E.R.2
  • 47
    • 0025113923 scopus 로고
    • Structure-specificity of the genotoxicity of some nat-urally occurring alkenylbenzenes determined by the unscheduled DNA synthesis assay in rat hepatocytes
    • Howes, A.J., Chan, V.S.W., and Caldwell, J. (1990). Structure-specificity of the genotoxicity of some nat-urally occurring alkenylbenzenes determined by the unscheduled DNA synthesis assay in rat hepatocytes. Food Chem. Toxicol. 28, 537-542.
    • (1990) Food Chem. Toxicol , vol.28 , pp. 537-542
    • Howes, A.J.1    Chan, V.S.W.2    Caldwell, J.3
  • 51
    • 0019788152 scopus 로고
    • Safrole: Its metabolism, carcinogenicity, and interactions with cytochrome P-450
    • Ioannides, C., Delaforge, M., and Parke, D.V. (1981). Safrole: Its metabolism, carcinogenicity, and interactions with cytochrome P-450. Food Cosmet. Toxicol. 19, 657-666.
    • (1981) Food Cosmet. Toxicol , vol.19 , pp. 657-666
    • Ioannides, C.1    Delaforge, M.2    Parke, D.V.3
  • 52
    • 85053984451 scopus 로고
    • The pharmacological studies on methyleugenol
    • Jiang, Y., Liu-GQ, Ma-Jr, Xie-L, and Wu-Hq (1982). The pharmacological studies on methyleugenol. Yao Hsueh Hsueh Pao 17, 87-92.
    • (1982) Yao Hsueh Hsueh Pao , vol.17 , pp. 87-92
    • Jiang, Y.1    Liu, Ma-Jr2    Xie, -L3    Wu-Hq4
  • 53
    • 0001616190 scopus 로고
    • Regulation of gastrointestinal mucosal growth
    • (J.H. Walsh, Ed), Raven Press, New York
    • Johnson, L.R., McCormack, S.A., and Wang, J.V. (1993). Regulation of gastrointestinal mucosal growth. In Gastrin (J.H. Walsh, Ed.), p. 287. Raven Press, New York.
    • (1993) Gastrin , pp. 287
    • Johnson, L.R.1    McCormack, S.A.2    Wang, J.V.3
  • 54
    • 0000941980 scopus 로고
    • A distribution-free k-sample test against ordered alternatives
    • Jonckheere, A.R. (1954). A distribution-free k-sample test against ordered alternatives. Biometrika 41, 133-145.
    • (1954) Biometrika , vol.41 , pp. 133-145
    • Jonckheere, A.R.1
  • 55
    • 0004907344 scopus 로고
    • Serum proteins and the dysproteinemias
    • (J.J. Kaneko, Ed), Academic Press, Inc., San Diego
    • Kaneko, J.J. (1989). Serum proteins and the dysproteinemias. In Clinical Biochemistry of Domestic Animals (J.J. Kaneko, Ed.), pp. 142-165. Academic Press, Inc., San Diego.
    • (1989) Clinical Biochemistry of Domestic Animals , pp. 142-165
    • Kaneko, J.J.1
  • 56
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • Kaplan, E.L., and Meier, P. (1958). Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53, 457-481.
    • (1958) J. Am. Stat. Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 57
    • 0029400640 scopus 로고
    • Investigation of mutagenicity of mineral trioxide aggregate and other commonly used root-end filling materials
    • Kettering, J.D., and Torabinejad, M. (1995). Investigation of mutagenicity of mineral trioxide aggregate and other commonly used root-end filling materials. J. Endod. 21, 537-542.
    • (1995) J. Endod , vol.21 , pp. 537-542
    • Kettering, J.D.1    Torabinejad, M.2
  • 58
  • 59
    • 0023269129 scopus 로고
    • Methotrexate-induced changes in rat parotid and submandibular gland function
    • McBride, R.K., Harper, C., and Siegel, I.A. (1987). Methotrexate-induced changes in rat parotid and submandibular gland function. J. Dent. Res. 66, 1445-1448.
    • (1987) J. Dent. Res , vol.66 , pp. 1445-1448
    • McBride, R.K.1    Harper, C.2    Siegel, I.A.3
  • 60
    • 0022573516 scopus 로고
    • Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies
    • McConnell, E.E., Solleveld, H.A., Swenberg, J.A., and Boorman, G.A. (1986). Guidelines for combining neoplasms for evaluation of rodent carcinogenesis studies. JNCI 76, 283-289.
    • (1986) JNCI , vol.76 , pp. 283-289
    • McConnell, E.E.1    Solleveld, H.A.2    Swenberg, J.A.3    Boorman, G.A.4
  • 61
    • 0016107169 scopus 로고
    • California bay oil. II. Biological effects of constituents
    • MacGregor, J.T., Layton, L.L., and Buttery, R.G. (1974). California bay oil. II. Biological effects of constituents. J. Agric. Food Chem. 22, 777-780.
    • (1974) J. Agric. Food Chem , vol.22 , pp. 777-780
    • MacGregor, J.T.1    Layton, L.L.2    Buttery, R.G.3
  • 62
    • 0020640986 scopus 로고
    • A simple fluorescent staining procedure for micronuclei and RNA in erythrocytes using Hoescht 33258 and pyronin Y
    • MacGregor, J.T., Wehr, C.M., and Langlois, R.G. (1983). A simple fluorescent staining procedure for micronuclei and RNA in erythrocytes using Hoescht 33258 and pyronin Y. Mutat. Res. 120, 269-275.
    • (1983) Mutat. Res , vol.120 , pp. 269-275
    • MacGregor, J.T.1    Wehr, C.M.2    Langlois, R.G.3
  • 63
    • 0025091492 scopus 로고
    • The in vivo erythrocyte micronucleus test: Measurement at steady state increases assay efficiency and permits integration with toxicity studies
    • MacGregor, J.T., Wehr, C.M., Henika, P.R., and Shelby, M.D. (1990). The in vivo erythrocyte micronucleus test: Measurement at steady state increases assay efficiency and permits integration with toxicity studies. Fundam. Appl. Toxicol. 14, 513-522.
    • (1990) Fundam. Appl. Toxicol , vol.14 , pp. 513-522
    • MacGregor, J.T.1    Wehr, C.M.2    Henika, P.R.3    Shelby, M.D.4
  • 65
    • 85047694480 scopus 로고
    • Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assessment
    • Maronpot, R.R., and Boorman, G.A. (1982). Interpretation of rodent hepatocellular proliferative alterations and hepatocellular tumors in chemical safety assessment. Toxicol. Pathol. 10, 71-80.
    • (1982) Toxicol. Pathol , vol.10 , pp. 71-80
    • Maronpot, R.R.1    Boorman, G.A.2
  • 66
    • 0026336802 scopus 로고
    • Furan-induced hepatic cholangiocarcinomas in Fischer 344 rats
    • Maronpot, R.R., Giles, H.D., Dykes, D.J., and Irwin, R.D. (1991). Furan-induced hepatic cholangiocarcinomas in Fischer 344 rats. Toxicol. Pathol. 19, 561-570.
    • (1991) Toxicol. Pathol , vol.19 , pp. 561-570
    • Maronpot, R.R.1    Giles, H.D.2    Dykes, D.J.3    Irwin, R.D.4
  • 67
    • 0024437655 scopus 로고
    • Negative evidence in vivo of DNA-damaging, mutagenic and chromosomal effects of eugenol
    • Maura, A., Pino, A., and Ricci, R. (1989). Negative evidence in vivo of DNA-damaging, mutagenic and chromosomal effects of eugenol. Mutat. Res. 227, 125-129.
    • (1989) Mutat. Res , vol.227 , pp. 125-129
    • Maura, A.1    Pino, A.2    Ricci, R.3
  • 68
    • 0020692513 scopus 로고
    • Structure&activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole
    • Miller, E.C., Swanson, A.B., Philips, D.H., Fletcher, T.L., Liem, A., and Miller, J.A. (1983). Structure&activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res. 43, 1124-1134.
    • (1983) Cancer Res , vol.43 , pp. 1124-1134
    • Miller, E.C.1    Swanson, A.B.2    Philips, D.H.3    Fletcher, T.L.4    Liem, A.5    Miller, J.A.6
  • 69
    • 0003896444 scopus 로고
    • Ultimate chemical carcinogens as reactive mutagenic electrophiles
    • (H.H. Hiatt, J.D. Watson, and J.A. Winsten, Eds), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
    • Miller, J.A., and Miller, E.C. (1977). Ultimate chemical carcinogens as reactive mutagenic electrophiles. In Origins of Human Cancer (H.H. Hiatt, J.D. Watson, and J.A. Winsten, Eds.), pp. 605-627. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
    • (1977) Origins of Human Cancer , pp. 605-627
    • Miller, J.A.1    Miller, E.C.2
  • 70
    • 0003504337 scopus 로고
    • 2nd ed., McGraw-Hill Book Company, New York
    • Morrison, D.F. (1976). Multivariate Statistical Methods, 2nd ed., pp. 170-179. McGraw-Hill Book Company, New York.
    • (1976) Multivariate Statistical Methods , pp. 170-179
    • Morrison, D.F.1
  • 71
    • 0022458177 scopus 로고
    • Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals
    • (Suppl. 7)
    • Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. (1986). Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. Environ. Mutagen. 8 (Suppl. 7), 1-119.
    • (1986) Environ. Mutagen , vol.8 , pp. 1-119
    • Mortelmans, K.1    Haworth, S.2    Lawlor, T.3    Speck, W.4    Tainer, B.5    Zeiger, E.6
  • 72
    • 0018036837 scopus 로고
    • Compounds new to essential orange oil from fruit treated with abscisson chemicals
    • Moshonas, M.G., and Shaw, P.E. (1978). Compounds new to essential orange oil from fruit treated with abscisson chemicals. J. Agric. Food Chem. 26, 1288-1290.
    • (1978) J. Agric. Food Chem , vol.26 , pp. 1288-1290
    • Moshonas, M.G.1    Shaw, P.E.2
  • 73
    • 0025744675 scopus 로고
    • Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: Results for 31 coded compounds in the National Toxicology Program
    • Myhr, B.C., and Caspary, W.J. (1991). Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: Results for 31 coded compounds in the National Toxicology Program. Environ. Mol. Mutagen. 18, 51-83.
    • (1991) Environ. Mol. Mutagen , vol.18 , pp. 51-83
    • Myhr, B.C.1    Caspary, W.J.2
  • 74
    • 0008882618 scopus 로고
    • National Academy of Sciences (NAS) Committee on Food Additives Survey Data, Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, Washington, DC
    • National Academy of Sciences (NAS) (1989). 1987 Poundage and Technical Effects Update of Substances Added to Food. Committee on Food Additives Survey Data, Food and Nutrition Board, Institute of Medicine, National Academy of Sciences, Washington, DC.
    • (1989) 1987 Poundage and Technical Effects Update of Substances Added to Food
  • 75
    • 0003979387 scopus 로고
    • National Cancer Institute (NCI) Technical Report Serie 1. NIH Publicatio 76-801. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Bethesda, MD
    • National Cancer Institute (NCI) (1976). Guidelines for Carcinogen Bioassay in Small Rodents. Technical Report Series No. 1. NIH Publication No. 76-801. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Bethesda, MD.
    • (1976) Guidelines for Carcinogen Bioassay in Small Rodents
  • 76
    • 0003827210 scopus 로고
    • National Institute for Occupational Safety and Health (NIOSH) unpublished provisional data as of July 1, 1990. NIOSH, Cincinnati, OH
    • National Institute for Occupational Safety and Health (NIOSH) (1990). National Occupational Exposure Survey (1981-1983), unpublished provisional data as of July 1, 1990. NIOSH, Cincinnati, OH.
    • (1990) National Occupational Exposure Survey (1981-1983)
  • 77
    • 85149012957 scopus 로고
    • National Institutes of Health (NIH) Specification NIH-11-1335. U.S. Department of Health, Education, and Welfare, Public Health Service, NIH, Bethesda, MD
    • National Institutes of Health (NIH) (1978). Open Formula Rat and Mouse Ration (NIH-07). Specification NIH-11-1335. U.S. Department of Health, Education, and Welfare, Public Health Service, NIH, Bethesda, MD.
    • (1978) Open Formula Rat and Mouse Ration (NIH-07)
  • 78
    • 77049091176 scopus 로고
    • Technical Report Serie 223. NIH Publicatio 84-1779. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC
    • 1 Mice (Feed Studies). Technical Report Series No. 223. NIH Publication No. 84-1779. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC.
    • (1983) 1 Mice (Feed Studies)
  • 80
    • 0003055343 scopus 로고
    • Specific proteins. C. Transport proteins
    • (W.F. Loeb and F.W. Quimby, Eds), Pergamon Press, Inc., New York
    • Nguyen, H.T. (1989). Specific proteins. C. Transport proteins. In The Clinical Chemistry of Laboratory Animals (W.F. Loeb and F.W. Quimby, Eds.), pp. 176-200. Pergamon Press, Inc., New York.
    • (1989) The Clinical Chemistry of Laboratory Animals , pp. 176-200
    • Nguyen, H.T.1
  • 81
    • 0024041540 scopus 로고
    • Mouse hepatoblastomas: A histologic, ultrastructural, and immunohistochemical study
    • Nonoyama, T., Fullerton, F., Reznik, G., Bucci, T.J., and Ward, J.M. (1988). Mouse hepatoblastomas: A histologic, ultrastructural, and immunohistochemical study. Vet. Pathol. 25, 286-296.
    • (1988) Vet. Pathol , vol.25 , pp. 286-296
    • Nonoyama, T.1    Fullerton, F.2    Reznik, G.3    Bucci, T.J.4    Ward, J.M.5
  • 85
    • 77957177350 scopus 로고
    • Testing for increased carcinogenicity using a survival-adjusted quantal response test
    • Portier, C.J., and Bailer, A.J. (1989). Testing for increased carcinogenicity using a survival-adjusted quantal response test. Fundam. Appl. Toxicol. 12, 731-737.
    • (1989) Fundam. Appl. Toxicol , vol.12 , pp. 731-737
    • Portier, C.J.1    Bailer, A.J.2
  • 86
    • 0022461712 scopus 로고
    • Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program&s carcinogenicity experiments
    • Portier, C.J., Hedges, J.C., and Hoel, D.G. (1986). Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program&s carcinogenicity experiments. Cancer Res. 46, 4372-4378.
    • (1986) Cancer Res , vol.46 , pp. 4372-4378
    • Portier, C.J.1    Hedges, J.C.2    Hoel, D.G.3
  • 87
    • 0025909655 scopus 로고
    • Neuroendocrine cell hyperplasia and neuroendocrine carcinoma of the rodent fundic stomach
    • Poynter, D., and Selway, S.A.M. (1991). Neuroendocrine cell hyperplasia and neuroendocrine carcinoma of the rodent fundic stomach. Mutat. Res. 248, 303-319.
    • (1991) Mutat. Res , vol.248 , pp. 303-319
    • Poynter, D.1    Selway, S.A.M.2
  • 88
    • 85149249899 scopus 로고
    • I R421. Sadtler Research Laboratories, Inc., Philadelphia
    • Sadtler Pharmaceuticals Grating Spectra (1974). IR No. R421. Sadtler Research Laboratories, Inc., Philadelphia.
    • (1974) Sadtler Pharmaceuticals Grating Spectra
  • 89
    • 0004152851 scopus 로고    scopus 로고
    • I 17520; U 5557; NM 4257M. Sadtler Research Laboratories, Inc., Philadelphia
    • Sadtler Standard Spectra. IR No. 17520; UV No. 5557; NMR No. 4257M. Sadtler Research Laboratories, Inc., Philadelphia.
    • Sadtler Standard Spectra
  • 90
    • 85149246976 scopus 로고
    • 8th ed. (R.J. Lewis, Sr., Ed), Van Nostrand Reinhold, New York
    • Sax's Dangerous Properties of Industrial Materials (1992). 8th ed. (R.J. Lewis, Sr., Ed.), pp. 2435-2437. Van Nostrand Reinhold, New York.
    • (1992) Sax's Dangerous Properties of Industrial Materials , pp. 2435-2437
  • 91
    • 0024329492 scopus 로고
    • Safrole, eugenol, and methyleugenol induce intrachromosomal recombination in yeast
    • Schiestl, R.H., Chan, W.S., Gietz, R.D., Mehta, R.D., and Hastings, P.J. (1989). Safrole, eugenol, and methyleugenol induce intrachromosomal recombination in yeast. Mutat. Res. 224, 427-436.
    • (1989) Mutat. Res , vol.224 , pp. 427-436
    • Schiestl, R.H.1    Chan, W.S.2    Gietz, R.D.3    Mehta, R.D.4    Hastings, P.J.5
  • 92
    • 0020028632 scopus 로고
    • Genotoxicity of safrole-related chemicals in microbial test systems
    • Sekizawa, J., and Shibamoto, T. (1982). Genotoxicity of safrole-related chemicals in microbial test systems. Mutat. Res. 101, 127-140.
    • (1982) Mutat. Res , vol.101 , pp. 127-140
    • Sekizawa, J.1    Shibamoto, T.2
  • 93
    • 0024312850 scopus 로고
    • Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma
    • Sell, S., and Dunsford, H.A. (1989). Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am. J. Pathol. 134, 1347-1363.
    • (1989) Am. J. Pathol , vol.134 , pp. 1347-1363
    • Sell, S.1    Dunsford, H.A.2
  • 94
    • 0014537231 scopus 로고
    • Effects of alkylmethoxybenzene and alkylmethylenedioxybenzene essential oils on pentobarbital and ethanol sleeping time
    • Seto, T.A., and Keup, K. (1969). Effects of alkylmethoxybenzene and alkylmethylenedioxybenzene essential oils on pentobarbital and ethanol sleeping time. Arch. Int. Pharmacodyn. 180, 232-240.
    • (1969) Arch. Int. Pharmacodyn , vol.180 , pp. 232-240
    • Seto, T.A.1    Keup, K.2
  • 95
    • 0029012454 scopus 로고
    • Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests
    • Shelby, M.D., and Witt, K.L. (1995). Comparison of results from mouse bone marrow chromosome aberration and micronucleus tests. Environ. Mol. Mutagen. 25, 302-313.
    • (1995) Environ. Mol. Mutagen , vol.25 , pp. 302-313
    • Shelby, M.D.1    Witt, K.L.2
  • 96
    • 0027526525 scopus 로고
    • Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals
    • Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. (1993). Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Mol. Mutagen. 21, 160-179.
    • (1993) Environ. Mol. Mutagen , vol.21 , pp. 160-179
    • Shelby, M.D.1    Erexson, G.L.2    Hook, G.J.3    Tice, R.R.4
  • 97
    • 0017745924 scopus 로고
    • A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment
    • Shirley, E. (1977). A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment. Biometrics 33, 386-389.
    • (1977) Biometrics , vol.33 , pp. 386-389
    • Shirley, E.1
  • 98
    • 0016217298 scopus 로고
    • Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis
    • (G. Klein, Ed), Academic Press, New York
    • Sims, P., and Grover, P.L. (1974). Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis. In Advances in Cancer Research (G. Klein, Ed.), Vol. 20, pp. 165-274. Academic Press, New York.
    • (1974) Advances in Cancer Research , vol.20 , pp. 165-274
    • Sims, P.1    Grover, P.L.2
  • 99
    • 8944224535 scopus 로고    scopus 로고
    • Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: Interim report of an international collaborative study
    • Sofuni, T., Honma, M., Hayashi, M., Shimada, H., Tanaka, N., Wakuri, S., Awogi, T., Yamamoto, K.I., Nishi, Y., and Nakadate, M. (1996). Detection of in vitro clastogens and spindle poisons by the mouse lymphoma assay using the microwell method: Interim report of an international collaborative study. Mutagenesis 11, 349-355.
    • (1996) Mutagenesis , vol.11 , pp. 349-355
    • Sofuni, T.1    Honma, M.2    Hayashi, M.3    Shimada, H.4    Tanaka, N.5    Wakuri, S.6    Awogi, T.7    Yamamoto, K.I.8    Nishi, Y.9    Nakadate, M.10
  • 100
    • 0017286721 scopus 로고
    • Metabolism of alkenebenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers
    • Solheim, E., and Scheline, R.R. (1976). Metabolism of alkenebenzene derivatives in the rat. II. Eugenol and isoeugenol methyl ethers. Xenobiotica 6, 137-150.
    • (1976) Xenobiotica , vol.6 , pp. 137-150
    • Solheim, E.1    Scheline, R.R.2
  • 102
    • 0016346972 scopus 로고
    • The metabolism of safrole and 2N,3N-epoxysafrole in the rat and guinea pig
    • Stillwell, W.G., Carman, M.J., Bell L., and Horning, M.G. (1974). The metabolism of safrole and 2N,3N-epoxysafrole in the rat and guinea pig. Drug Metab. Dispos. 2, 489-498.
    • (1974) Drug Metab. Dispos , vol.2 , pp. 489-498
    • Stillwell, W.G.1    Carman, M.J.2    Bell, L.3    Horning, M.G.4
  • 104
    • 0002460382 scopus 로고
    • Consumption ratio and food predominance of flavoring materials
    • Stofberg, J., and Grundschober, F. (1987). Consumption ratio and food predominance of flavoring materials. Perfumer and Flavorist 12, 27.
    • (1987) Perfumer and Flavorist , vol.12 , pp. 27
    • Stofberg, J.1    Grundschober, F.2
  • 105
    • 0019795075 scopus 로고
    • Somatic mutation, cellular differentiation, and cancer causation
    • Straus, D.S. (1981). Somatic mutation, cellular differentiation, and cancer causation. JNCI 67, 233-241.
    • (1981) JNCI , vol.67 , pp. 233-241
    • Straus, D.S.1
  • 106
    • 0031984227 scopus 로고    scopus 로고
    • $-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors
    • Takahashi, M., Fukuda, K., Sugimura, T., and Wakabayashi, K. (1998). $-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Cancer Res. 58, 42-46.
    • (1998) Cancer Res , vol.58 , pp. 42-46
    • Takahashi, M.1    Fukuda, K.2    Sugimura, T.3    Wakabayashi, K.4
  • 107
    • 0016759979 scopus 로고
    • Tests for trend in life table analysis
    • Tarone, R.E. (1975). Tests for trend in life table analysis. Biometrika 62, 679-682.
    • (1975) Biometrika , vol.62 , pp. 679-682
    • Tarone, R.E.1
  • 114
    • 0015025451 scopus 로고
    • A test for differences between treatment means when several dose levels are compared with a zero dose control
    • Williams, D.A. (1971). A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 27, 103-117.
    • (1971) Biometrics , vol.27 , pp. 103-117
    • Williams, D.A.1
  • 115
    • 0015357959 scopus 로고
    • The comparison of several dose levels with a zero dose control
    • Williams, D.A. (1972). The comparison of several dose levels with a zero dose control. Biometrics 28, 519-531.
    • (1972) Biometrics , vol.28 , pp. 519-531
    • Williams, D.A.1
  • 116
    • 0023033358 scopus 로고
    • Evaluation of eugenol for mutagenicity by the mouse micronucleus test
    • Woolverton, C.J., Fotos, P.G., Mokas, M.J., and Mermigas, M.E. (1986). Evaluation of eugenol for mutagenicity by the mouse micronucleus test. J. Oral Pathol. 15, 450-453.
    • (1986) J. Oral Pathol , vol.15 , pp. 450-453
    • Woolverton, C.J.1    Fotos, P.G.2    Mokas, M.J.3    Mermigas, M.E.4
  • 118
    • 0025184162 scopus 로고
    • Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicals
    • (Suppl. 18)
    • Zeiger, E., Haseman, J.K., Shelby, M.D., Margolin, B.H., and Tennant, R.W. (1990). Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicals. Environ. Mol. Mutagen. 16 (Suppl. 18), 1-14.
    • (1990) Environ. Mol. Mutagen , vol.16 , pp. 1-14
    • Zeiger, E.1    Haseman, J.K.2    Shelby, M.D.3    Margolin, B.H.4    Tennant, R.W.5


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