Transgenic and Knockout Models of Psychiatric Disorders: Introduction, History, and Assessment

Contemporary Clinical Neuroscience

Volumn , Issue , 2006, Pages 3-23

  Fisch, Gene S ^a  

^a NONE

Author keywords

Animals models; behaviorism; cognitive psychology; experimantal psychology; genetics; mouse models; neuroscience; psychiatric disorders

Indexed keywords

EID: 85145920901     PISSN: 2627535X     EISSN: 26275341     Source Type: Book Series    
DOI: 10.1007/978-1-59745-058-4_1     Document Type: Chapter

References (95)

1. Royce JE. Man and His Nature. New York: McGraw-Hill, 1961, p. 3.
2. McDougall W. An experiment for testing the hypothesis by Lamarck. Br J Psychol 1927;17:267–304.
3. Darwin CR. On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life. London: John Murray, 1859.
4. Darwin C. The Expression of the Emotions in Man and Animals. London: John Murray, 1872.
5. Darwin C. The Descent of Man. 2 Vols. London: John Murray, 1871.
6. Spalding DA. Instinct: with original observations oNYoung animals. MacMillan’s Magazine 1873;27:282–293.
7. Lubbock J. Ants, Bees, and Wasps. New York: D. Appleton, 1884.
8. Romanes GS. Animal Intelligence. London: Kegan Paul, 1882.
9. Lloyd Morgan C. An Introduction to Comparative Psychology. London: Walter Scott, 1894.
10. Wundt W. Lectures on Human and Animal Psychology. Creighton JE, Titchener EB, trans. London: Swan Sonnenshein & Sons, 1894.
11. Thorndike EL. Animal intelligence: an experimental study of the associative processes in animals. The Psychological Review Monograph Supplements, 1898; 8.
12. Yerkes RM. The formation of habits in the turtle. The Popular Science Monthly 1901;58:519–529.
13. Thorndike EL. The Elements of Psychology. New York: Seiler, 1905, p. 203.
14. Jennings HS. Behavior of Lower Organisms. New York: Columbia University Press, 1906.
15. Sherrington C. The Integrative Action of the Nervous System. Reprinted 1947. New Haven: Yale University Press, 1906/1947.
16. Loeb J. Forced Movements, Tropisms, and Animal Conduct. Reprinted 1973. New York: Dover Publications, 1918/1973.
17. Holmes SJ. The Evolution of Animal Intelligence. New York: Henry Holt, 1911.
18. Pavlov IP. Lectures on the Conditioned Reflexes. Gantt WH, trans. New York: Liveright Publishing, 1928.
19. Washburn MF. The Animal Mind. 3rd ed. New York: MacMillan, 1930.
20. Watson JB. Psychology as the behaviorist views it. Psychological Review 1913;20:158–177.
21. Köhler W. The Mentality of Apes. Winter E, trans. New York: Harcourt Brace, 1927.
22. Skinner BF. The Behavior of Organisms. Reprinted 1966. Englewood Cliffs: Prentice-Hall, 1938.
23. Maier NRF, Schneirla TC. Principles of Animal Psychology. Reprinted 1964, New York: Dover Publications, 1935.
24. Hunter WS. The delayed reaction in animals and children. Behavior Monographs 1913;2:86.
25. Hinde RA. Animal Behaviour: A Synthesis of Ethology and Comparative Psychology. 2nd ed. New York: McGraw-Hill, 1970.
26. Voronin LG. Some results of comparative-physiological investigations of higher nervous activity. Psychol Bull 1962;59:161–195.
27. Warren JM. Learning in Vertebrates. In: Dewsbury DA, Rethlingshafer DA, eds. Comparative Psychology: A Modern Survey. New York: McGraw-Hill, 1973.
28. Tinbergen N. The Study of Instinct. Oxford: Clarendon, 1951.
29. Lorenz KL. The comparative method in studying innate behaviour patterns. Symp Soc Exp Biol 1950;4:221–268.
30. Shettleworth SJ. Biological Approaches to the Study of Learning. In: Mackintosh NJ, ed. Animal Learning and Cognition. San Diego: Academic, 1994, pp. 185–219.
31. Ten Cate C. Behavioral development: towards understanding processes. Perspectives in Ethology 1989;8:243–269.
32. de Vos GJ, van Kampen HS. Effects of primary imprinting on the subsequent development of
33. Stoddard PK, Beecher MD, Loesche P, Campbell SE. Memory does not constrain individual recognition in a bird with song repertoires. Behaviour 1992;122:271–284.
34. Mackintosh NJ. Approaches to the study of animal intelligence. Br J Psychol 1988;79:509–525.
35. Blackman DE. On the Cognitive Theories of Animal Learning: Extrapolation from Humans to Animals? In: Davey GCL, ed. Animal Models of Human Behavior. London: John Wiley & Sons, 1983, pp. 37–50.
36. Zeldin RK, Olton DS. Rats acquire spatial learning sets. J Exp Psychol 1986;37B:295–311.
37. Devine JV. Stimulus attributes and training procedures in learning-set formation of rhesus and cebus monkey. J Comp Physiol Psychol 1970;73:62–67.
38. Macphail EM. Brain and Intelligence in Vertebrates. Oxford: Oxford University Press, 1982.
39. Pearce JM. Discrimination and Categorization. In: Mackintosh NJ, ed. Animal Learning and Cognition. San Diego: Academic, 1994, pp. 109–134.
40. Bluton-Jones NG. Two Investigations of Human Behavior Guided by Evolutionary Theory. In: Davey GCL, ed. Animal Models of Human Behavior, London: John Wiley & Sons Ltd, 1983, pp. 179–204.
41. Hebb DO. The Organization of Behavior. New York: Wiley, 1949.
42. Lashley KS. Brain Mechanisms and Intelligence. Chicago: University of Chicago Press, 1929.
43. Hamilton V, Vernon MD. The Development of Cognitive Processes. London: Academic, 1976.
44. Watkins MJ. An Experimental Psychologist’s View of Cognitive Science. In: Lister RG, Weingartner HJ, eds. Perspectives in Cognitive Neuroscience. Oxford: Oxford University Press, 1991, pp. 132–144.
45. Neisser U. Cognitive Psychology. New York: Appleton Century Crofts, 1967.
46. Newall A, Simon HA. Human Problem Solving. Englewood Cliffs: Prentice-Hall, 1972.
47. Cowan WM, Harter DH, Kandel ER. The emergence of modern neuroscience: some implications for neurology and psychiatry. Annu Rev Neurosci 2000;23:343–391.
48. Eccles JC. The Neurophysiological Basis of Mind: The Principle of Neurophysiology. Oxford: Clarendon, 1953.
49. Evarts EV. Relation of pyramidal tract activity to force exerted during voluntary movement. J Neurophysiol 1968;31:14–27.
50. Galton F. Inquiries into Human Faculty and its Development. New York: MacMillan, 1883.
51. Scheerenberger RC. A History of Mental Retardation. Baltimore: Brookes, 1982.
52. Ten Cate C, Los L, Schilperood L. The influence of differences in social experience on the devel
53. Lejeune J, Gautier M, Turpin R. Etudes des chromosomes somatiques de neuf enfants mongoliens. CR Academie de Science 1959;248:1721.
54. Lubs HA . A marker X chromosome. Am J Hum Genet, 1969;21:231–244.
55. Kraepelin E. Compendium der Psychiatrie zum Gebrauche für Studirende und Aerzte. Leipzig: Abel Verlag, 1883.
56. Kallman FJ. The Genetics of Mental Illness. In: Arieti S, ed. American Handbook of Psychiatry. New York: Basic Books, 1959.
57. Gottesman II. Schizophrenia Genesis—The Origins of Madness. New York: WH Freeman, 1991.
58. Cannon TD, Thompson PM, van Erp TG, et al. Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia. Proc Natl Acad Sci USA 2002;99(5):3228–3323.
59. Anderson B. Role for animal research in the investigation of human mental retardation. Am J Ment Retard 1994;99:50–59.
60. Thompson R, Crinella FM, Yu J. Brain Mechanisms in Problem Solving and Intelligence. New York: Plenum, 1990.
61. Morris RGM. Spatial localization does not require the presence of local cues. Learn Motiv 1981;12:239–260.
62. Morris RGM, Garrud P, Rawlins JNP, O’Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature (London) 1982;297:681–683.
63. Scoville WB, Milner BJ. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 1957;20:11–21. Reprinted in J Neuropsychiatry Clin Neurosci 2000;12:103–113.
64. Rudy JW, Sutherland RJ. The hippocampal formation is necessary for rats to learn and remember configural discriminations. Behav Brain Res 1989;34:97–109.
65. Gerlai RT, McNamara A, Williams S, Phillips HS. Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue? Brain Res Bull 2002;57:3–9.
66. Morris RGM. The Neural Basis of Learning with Particular Reference to the Role of Synaptic Plasticity. In: Mackintosh NJ, ed. Animal Learning and Cognition. San Diego: Academic, 1994.
67. Grant SG, O’Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 1992;258(5090): 1903–1910.
68. Pavlov IP. Lectures on Conditioned Reflexes Volume II. Conditioned Reflexes and Psychiatry. WH Gantt, trans. New York: International Publishing, 1941.
69. Andy OJ. Psychomotor-psychic seizures treated with bilateral amygdalotomy and orbitotomy. South Med J 1976;69:88–93.
70. Goddard GV. Analysis of avoidance conditioning following cholinergic stimulation of amygdala in rats. J Comp Physiol Psychol 1969;68:1–18.
71. Slotnick BM. Fear behavior and passive avoidance deficits in mice with amygdala lesions. Physiol Behav 1973;11:717–720.
72. Maren S. The amygdala, synaptic plasticity, and fear memory. Ann NY Acad Sci 2003;985:106–113.
73. Wilensky AE, Schafe GE, LeDoux JW. The amygdala modulates memory consolidation of fearmotivated inhibitory avoidance learning but not classical fear conditioning. J Neurosci 2000;20:7059–7066.
74. Crawley JN. Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 1999;835:18–26.
75. Dutch-Belgian Fragile X Consortium. Fmr1 knockout mice: a model to study fragile X mental retardation. Cell 1994;15:23–33.
76. Reeves RH, Irving NG, Moran TH, et al. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nature Genet 1995;11:177–184.
77. D’Adamo P, Welzl H, Papadimitriou S, et al. Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice. Hum Mol Genet 2002;11:2567–2580.
78. Shahbazian M, Young J, Yuva-Paylor L, et al. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron 2002;35:243–254.
79. Muscatelli F, Abrous DN, Massacrier A, et al. Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome. Hum Mol Genet 2000;9:3101–3110.
80. Liu H, Abecasis GR, Heath SC, et al. Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc Natl Acad Sci USA 2002;99:16,859–16,864.
81. DeSilva U, Elnitski L, Idol JR, et al. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. Genome Res 2002;12:3–15.
82. Bayarsaihan D, Dunai J, Greally JM, et al. Genomic organization of the genes Gtf2ird1, Gtf2i, and Ncf1 at the mouse chromosome 5 region syntenic to the human chromosome 7q11.23 Williams syndrome critical region. Genomics 2002;79:137–143.
83. Seznec H, Agbulut O, Sergeant N, et al. Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities. Hum Mol Genet 2001;10:2717–2726.
84. Gallagher M, Rapp PR. The use of animal models to study the effects of aging on cognition. Annu Rev Psychol 1997;48:339–370.
85. Kordower JH, Gash DM. Animal models of age-and disease-related cognitive decline: perspectives on the models and therapeutic strategies. Neurobiol Aging 1988;9:685–689.
86. Strupp BJ, Levitsky DA, Blumstein L. PKU, learning, and models of mental retardation. Dev Psychobiol 1984;17:109–120.
87. Paylor R, Hirotsune S, Gambello MJ, Yuva-Paylor L, Crawley JN, Wynshaw-Boris A. Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice. Learn Mem 1999;6:521–537.
88. Dalvi A, Lucki I. Murine models of depression. Psychopharmacology (Berl) 1999;147:4–6.
89. Clement Y, Calatayud F, Belzung C. Genetic basis of anxiety-like behaviour: a critical review. Brain Res Bull 2002;57:57–71.
90. Flint J. Genetic effects on an animal model of anxiety. FEBS Lett 2002;529:131–134.
91. Tremolizzo L, Carboni G, Ruzicka WB, et al. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci USA 2002;99:17,095–17,100.
92. Ellenbroek BA, Cools AR. Apomorphine susceptibility and animal models for psychopathology: genes and environment. Behav Genet 2002;32:349–361.
93. Wahlsten D. Standardized tests of mouse behavior: reasons, recommendations, and reality. Physiol Behav 2001;73:695–704.
94. Phillips TJ, Belknap JK, Hitzemann RJ, Buck KJ, Cunningham CL, Crabbe JC. Harnessing the mouse to unravel the genetics of human disease. Genes Brains Behav 2002;1:14–26.
95. Crabbe JC, Wahlsten D, Dudek BC. Genetics of mouse behavior: interactions with laboratory environment. Science 1999;284:1670–1672.