The first human clinical study for nmn has started in japan

npj Aging and Mechanisms of Disease

Volumn 2, Issue 1, 2016, Pages

  Tsubota, Kazuo ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85136179214     PISSN: None     EISSN: 20563973     Source Type: Journal    
DOI: 10.1038/npjamd.2016.21     Document Type: Editorial

References (6)

1. + and sirtuins in aging/ longevity control. NPJ Aging Mech Dis 2, 16017 (2016).
2. Imai, S., Armstrong, C. M., Kaeberlein, M. & Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795–800 (2000).
3. Kaeberlein, M., Rabinovitch, P. S. & Martin, G. M. Healthy aging: The ultimate preventative medicine. Science 350, 1191–1193 (2015).
4. Check Hayden, E. Anti-ageing pill pushed as bona fide drug. Nature 522, 265–266 (2015).
5. Onken, B. & Driscoll, M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS ONE 5, e8758 (2010).
6. Clinical Trial registration number UMIN000021309: Assessment of the safety of nicotinamide mononucleotide (NMN) in healthy subjects; phase I study. The clinical trial to evaluate metabolic-syndrome-related parameters to develop NMN as Foods with Function Claims. Available at https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&language=J&recptno=R00024575. Accessed 23 September 2016.