Ionophores

Veterinary Toxicology: Basic and Clinical Principles

Volumn , Issue , 2007, Pages 1021-1041

  Novilla, Meliton N ^a  

^a UNIVERSITY OF PRINCE EDWARD ISLAND   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85135550515     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012370467-2/50180-2     Document Type: Chapter

References (187)

1. Adovelande JB, Schrevel J Carboxylic ionophores in malaria chemotherapy, the effects of monensin and nigericin on Plasmodium falciparum in vitro and. Plasmodium vinckelpetteri in vivo. Pharmacol Lett 1996, 59:309-315.
2. Agaoglu ZT, Akgul Y, Keles I, Ugras S, Aksoy A, Cinar A Accidental salinomycin intoxication of Angora goats in Turkey. Small Ruminant Res 2002, 45:159-161.
3. Amend JF, Mallon FM, Wren WB, Ramos AS Equine monensin toxicosis, some experimental clinicopathologic observations. Comp Cont Ed 1981, 11:S173-S183.
4. Anadon A, Reeve-Johnson L Macrolide antibiotics, drug interactions and microsomal enzymes, implications for veterinary medicine. Res Vet Sci 1999, 66:197-203.
5. Anderson TD, Van Alstine WG, Ficken MD, Miskimins DW, Carson TL, Osweiler GD Acute monensin toxicosis in sheep, light and electron microscopic changes. Am J Vet Res 1984, 45:1142-1147.
6. Atef M, Ramadan A, Abo El-Sooud K Pharmacokinetic profile and tissue distribution of monensin in broiler chickens. Brit Poultry Sci 1993, 34:195-203.
7. Baird DJ, Caldow GL, Peek IS, Grant DA Monensin toxicity in a flock of ostriches. Vet Rec 1997, 140:624-626.
8. Basaraba RJ, Oehme FW, Vorhies MW, Stokka GL Toxicosis in cattle from concurrent feeding of monensin and dried distillers grains contaminated with macrolide antibiotics. J Vet Diagn Invest 1999, 11:79-86.
9. Bastianello SS, Fourie N, Prozesky L, Nel PW, Kellerman TS Cardiomyopathy of ruminants induced by the litter of poultry fed on ration containing the ionophore antibiotic maduramicin. II. Macropathology and histopathol. Onderstepoort J Vet Res 1991, 62:5-18.
10. Beck BE, Harries WN The diagnosis of monensin toxicity, a report on outbreaks in horses, cattle and chickens. Proc Am Assn Vet Lab Diagn 1979, 22:269-282.
11. Bergen WG, Bates DB Ionophores, their effect on production efficiency and mode of action. J Anim Sci 1984, 58:1465-1483.
12. Bertini S, Feirrero S, Berny P A new improved high performance thin layer chromatography (HPTLC) method for the detection of ionophore antibiotics in feeds and animal tissues. J Liq Chrom Rel Technol 2003, 26:147-156.
13. Bezerra PS, Driemeier D, Loretti AP, Riet-Correa E, Kamphues J, De Barros CS Monensin toxicity in Brazilian horses. Vet Hum Toxicol 1999, 41:383-385.
14. Bila CG, Perreira CL, Gruys E Accidental monensin toxicosis in horses in Mozambique. J S Afr Vet Assoc 2001, 72:163-164.
15. Black B, McQuilken G Ajudgment against sudden death. Calf News 1980, 18:28.
16. Bradley R, Markson LM, Bailey J Sudden death and myocardial necrosis in cattle. J Pathol 1981, 135:19-38.
17. Bounque JG, Smart M, Wobeser C Monensin toxicity in lambs. Can Vet J 1986, 27:397-399.
18. Broz J, Frigg M Incompatibility between lasalocid and chloramphenicol in broiler chicks after long term administration. Vet Res Comm 1987, 11:159-172.
19. Buck WB, Osweiller GD, Van Odder CA Clinical and Diagnostic Veterinaty Toxicology 1976, Kendall/Hunt Publishing Co., Dubuque, IA. 2nd edn.
20. Buxton D, Blewett DA, Trees AJ, McGolgan C, Finlayson J Further studies in the use of monensin in the control of experimental ovine toxoplasmosis. J Comp Path 1988, 98:225-235.
21. Caldeira C, Neves WS, Cury PM, Serrano P, Baptista MASF, Burdmann EA Rhabdomyolysis, acute renal failure, and death after monensin ingestion. Am J Kidney Dis 2001, 38:1108-1112.
22. Calo M, Locascio P, Licata P, Richetti A, Zaccone G, Naccari F Effects of monensin on Na_-ATPAse and Ca2_-ATPase activities in chick skeletal muscle and myocardium after subacute treatment. Eur J Histochem 2002, 46:309-315.
23. Calo M, Martini D, Locascio Naccari F Effects of monensin on nitric oxide synthases in chick cardiac muscle. J Vet Pharmacol Therap 2003, 26(Suppl. 1):82-87.
24. Cardona CJ, Galey FD, Bickford AA, Charlton BR, Cooper G A syndrome in commercial turkeys in California and Oregon characterized by a rear-limb necrotizing myopathy. Avian Dis 1992, 36:1092-1101.
25. Cardona CJ, Galey FD, Bickford AA, Charlton BR, Cooper GL Skeletal myopathy produced with experimental dosing of turkeys with monensin. Avian Dis 1993, 37:107-117.
26. Carpenter JW, Novilla MN Safety and physiologic effects of the anticoccidial drugs monensin and clasuril in sandhill cranes (Grus canadensis). J Zoo Wild Med 1992, 23:214-221.
27. Ceppa L, Nachtman C, Dacasto M, Carletti M, Nebbia C The effect of hepatic microsomal cytochrome P450 monooxygenases on monensin-sulfadimidine interaction in broilers. J Vet Pharmacol Therap 1997, 24:73-76.
28. Condon FP, McKenzie RA Fatal monensin toxicity in a dog after chewing a bovine intraruminal slow-release device. Aust Vet Pract 2002, 32:179-180.
29. Confer AW, Reavis DI, Panciera RI Light and electron microscopic changes in cardiac and skeletal muscle of sheep with experimental monensin toxicosis. Vet Pathol 1983, 20:590-602.
30. Coyle D, Walker A A study to determine the residues of monensin in edible tissues of growing cattle following treatment at 0.9 mg monensin/kg body weight for 28 days 2005, Submitted to the European Medicines Agency CVMP by Elanco Animal Health, Division of Eli Lilly and Company, Indianapolis, IN, USA.
31. Cruickshank JM The role of coronary perfusion pressure. Eur Heart J 1992, 13(Suppl. D):39-43.
32. Cullen JM, Wilson M, Hagler WM, Ort FJ, Cole RJ Histologic lesions in broiler chicks given cyclopiazonic acid orally. Am J Vet Res 1988, 49:728-731.
33. Czarnecki CM Cardiomyopathy in turkeys. Comp Biochem Physiol 1984, 77:591-598.
34. Davison KL Monensin absorption and metabolism in calves and chickens. J Agric Food Chem 1984, 32:1273-1277.
35. De Guzman NT, Pressman BC The inotropic effect of the calcium ionophore X-537A in the anesthetized dog. Circulation 1974, 49:1072-1077.
36. Donoho AL Biochemical studies on the fate of monensin in animals and in the environment. J Anim Sci 1984, 58:1528-1539.
37. Donoho A, Manthey J, Occolowitz J, Zornes L Metabolism of monensin in the steer and rat. J Agric Food Chem 1978, 26:1090-1095.
38. Dorn P, Weber R, Weikel J, Wessling E Intoxikation durch geichzeitge Verabreichung von Chloramphenicol und Monensin bei Puten. Der Praktische Tierarzt 1983, 64:240-243.
39. Dowling L Ionophore toxicity in chickens, a review of pathology and diagnosis. Avian Pathol 1992, 30:358-368.
40. DuBourdieu DJ, Shier WT Sodium-and calcium-dependent steps in the mechanism of neonatal rat cardiac myocyte killing by ionophores. II. The calcium carrying ionophore A23187. Toxicol Appl Pharmacol 1992, 116:47-56.
41. Duffield T, Bagg R, DesCoteaux L, Bouchard E, Brodeur M, DuTremblay D, Keefe G, LeBlanc S, Dick P Prepartum monensin for the reduction of energy associated disease in postpartum cows. J Dairy Sci 2002, 85:397-405.
42. Ebel JG, Wachs T, Henion JD Rapid forensic selected reaction monitoring liquid chromatography/mass spectrometry determination of ionophore antibiotics found at toxic levels in animal fee. J Assoc Off Anal Chem 2004, 87:25-30.
43. Egyed MN, Perl S, Klopper U, Shlosberg A, Yakobson B, Nobel TA Monensin toxicosis in cattle and sheep with reference to its differential diagnosis. Isr J Vet Med 1987, 43:204-211.
44. Engelhardt JA, Carlton WW, Tuite JF Toxicity of Fusarium moniliforme var subglutinans for chicks, ducklings, and turkey poults. Avian Dis 1989, 33:357-360.
45. Evans RD, Edson RK, Watkins KL, Robertson JL, Meldrum JB, Novilla MN Turkey knockdown in successive flocks. Avian Dis 2000, 44:730-736.
46. Fajer-Avila EJ, Covarrubias MSM, Abad-Rosales S, Roque A, Mesa-Bojorquez P, Hernandez-Gonzalez C Effectiveness of oral Elancoban™ and Avimix-ST™ against Nematopsis (Apicomplexa, Porosporidae) gametocytes infecting the shrimp. Litopenaeus vannamei. Aquaculture 2005, 244:11-18.
47. Feliciano L, Henning RJ Coronary artery blood flow, physiologic and pathophysiologic regulation. Clin Cardiol 1999, 22:775-786.
48. Ficken MD, Wages DP, Gonder E Monensin toxicity in turkey breeder hens. Avian Dis 1989, 33:186-190.
49. Food Drug Administration, CFR Parts 556 and 558 Approval of supplemental NADA for the use of monensin Type A medicated articles to formulate Type and Type C medicated feeds for increased milk production eff. Federal Register 2004, 69:68783-68784.
50. Fourie N, Bastianello SS, Prozesky L, Nel PW, Kellerman TS Cardiomyopathy of ruminants induced by the litter of poultry fed on ration containing the ionophore antibiotic maduramicin. I. epidemiology, clinical signs, a. Onderstepoort J Vet Res 1991, 58:291-296.
51. Frigg M, Broz J, Weber G Compatibility studies of ionophore anticoccidials with various antibiotics and chemotherapeutics in broiler chicks. Archiv Fur Geflugelkunde 1983, 47:213-220.
52. Galitzer SJ, Oehme FW A literature review on the toxicity of lasalocid, a polyether antibiotic. Vet Hum Toxicol 1984, 26:322-326.
53. Galitzer SJ, Bartley FF, Oehme FW Preliminary studies on lasalocid toxicosis in cattle. Vet Hum Toxicol 1982, 24:406-409.
54. Galitzer SJ, Kruckenburg SM, Kidd JR Pathologic changes associated with experimental lasalocid and monensin toxicosis in cattle. Am J Vet Res 1986, 47:2624-2626.
55. Galitzer SJ, Oehme FW, Bartley EE, Dayton AD Lasalocid toxicity in cattle, acute clinicopathological changes. J Anim Sci 1986, 62:1308-1316.
56. Gossett FO, Gibson WR, Koenig GR, Marroquin F, Young SS, Worth HM Morton DM Dietary relay studies in dogs and rats to evaluate the safety of tissues from cattle fed Rumensin® (mycelial monensin sodium). Lilly Research Laboratories 1975, Submitted to the European Medicines Agency CVMP by Elanco Animal Health, Division of Eli Lilly and Company, Indianapolis, IN, USA.
57. Gough AW, Pinn S, Hulland TJ, Thomson RG, de la Iglesia F Spontaneous cardiomyopathy, histopathologic and ultrastructural alterations in turkey heart tissue. Am J Vet Res 1981, 42:1290-1297.
58. Griffin T, Ryback ME, Recht L, Singh M, Raso V Potentiation of anti-tumor immunotoxins by liposomal monensin. J Natl Cancer Inst 1993, 85:292-298.
59. Gumila C, Ancelin ML, Delort AM, Jeminet G, Vial HJ Characterization of the potent in vitro and in vivo antimalarial activities of ionophore compounds. Antimicrob Agents Chemothe 1997, 41:523-529.
60. Hall JO Toxic feed constituents in the horse. Vet Clin North Am Equine Pract 2001, 17:1098-1100.
61. Halvorson DA, Van Dijk C, Brown P lonophore toxicity in turkey breeders. Avian Dis 1982, 26:634-639.
62. Hamidinia SA, Shimelis OI, Tan B, Erdahl WL, Chapman CJ, Renkes GD, Taylor RW, Pfeiffer DR Monensin mediates a rapid and selective transport of Pb2_ possible application of monensin for the treatment of Pb2_ intoxication. J Biol Chem 2002, 277:3811-3820.
63. Hammond AC, Carlson JR, Breeze RG Prevention of tryptophaninduced acute bovine pulmonary edema and emphysema. Vet Rec 1980, 107:322-325.
64. Hanley HG, Slack JD Pharmacology of lasalocid. Polyether Antibiotics 1982, 341-395. Marcel Dekker, New York. J.W. Westley (Ed.).
65. Hanrahan LA, Corner DF, Naqi SA Monensin toxicosis in broiler chickens. Vet Pathol 1981, 18:665-671.
66. Hanson LJ, Eisenbeis HG, Givens SV Toxic effect of lasalocid in horses. Am J Vet Res 1981, 42:456-461.
67. Hazlett MJ, Houston DM, Maxie MG, Van Dreumel T, Ramsey J Monensin/roxarsone contaminated dog food associated with myodegeneration and renal medullary necrosis in dogs. Can Vet J 1992, 33:749.
68. Herberg R, Manthey J, Richardson L, Cooley C, Donoho A Excretion and tissue distribution of 14C monensin in cattle. J Agric Food Chem 1978, 26:1087-1090.
69. Heuer C, Schuken YH, Jonker, LJ, Wilkinson JID, Noorhuizen JPTM Effect of monensin on blood ketones bodies, incidence and recurrence of disease and fertility in dairy cows. J Dairy Sci 2001, 84:1085-1097.
70. Holland DR Cardiovascular and respiratory effects of sodium monensin, IV and PO, in conscious dogs. Lilly Research Laboratories 1978, Submitted to the European Medicines Agency CVMP by Elanco Animal Health, IN, Division of Eli Lilly and Company, Indianapolis.
71. Hormazabal V, Yndestad M, Ostensvik O Determination of amprolium, ethopabate, lasalocid, monensin, narasin, and salinomycin in feed by liquid chromoatography-mass spectrometry. J Liq Chrom Rel Technol 2002, 25:2655-2663.
72. Horrox ME Monensin-tiamulin interaction risk to poultry. Vet Rec 1980, 106:178.
73. Hubert LC, Oehme FW Plants Poisonous to Livestock 1968, Kansas State University Printing Service, Manhattan, KS. 3rd edn.
74. Jones TC, Overstreet RM, Lotz JM, Frelier FP Paraphidioidina scolecoides n. sp., a new aseptate gregarine from cultured Pacific white shrimp. Pennaeus vannamei Dis Aquat Org 1994, 19:67-75.
75. Julian RJ, Mirsalimi SM, Bagley LG, Squires EJ Effect of hypoxia and diet on spontaneous cardiomyopathy (round-heart disease). Avian Dis 1992, 36:1043-1047.
76. Kingsbury JM Poisonous plants of the United States and Canada 1964, Prentice-Hall, Inc., Englewood Cliffs, NJ.
77. Kennington AS, Darby JM, Ehrenfried KM, Kiehl DE, Moran JW Sweeney DJ [14C]Monensin milk and tissue residues/ metabolism in dairy cows 1995, Submitted to the European Medicines Agency CVMP by Elanco Animal Health, net, Division of Eli Lilly and Company, Indianapolis, USA.
78. Kouyoumdjian JA, Morita MD, Sato AK, Pissolatti AF Fatal rhabdomyolysis after acute sodium monensin (Rumensin) toxicity, case report. Arq Neuropsiquiatr 2001, 59:596-598.
79. Kyriakis SC The effect of monensin against swine dysentery. Br Vet J 1989, 143:373-377.
80. Kyriakis SC, Vlemmas JC, Mavromatis JC, Tsinas AC, Lekkas SG, Tsangaris TA The effect of monensin in the control of transmissible gastroenteritis (TGE) of pigs. Swine Health Prod 1993, 1:15-18.
81. Lin JA Mass salinomycin toxicity death due to concomitant use of tiamulin in a breeder flock. Taiwan J Vet Med Anim Husb 1995, 65:339-346.
82. Long P, Jeffers TK Studies on the stage of action of ionophorous antibiotics against Eimeria. J Parasitol 1982, 68:363-371.
83. Lowe BL, Ball GJ, Carruthers VR, Dobos RC, Lynch GA, Moate PJ, Poole PR, Valentine SC Monensin controlled-release intraruminal capsule for control of bloat in pastured dairy cows. Aust Vet J 1991, 68:17-20.
84. Maronpot RR, Bucci TJ, Stedham MA Focal degenerative myopathy in turkeys. Avian Dis 1968, 12:96-103.
85. Matsuoka T Evaluation of monensin toxicity in the horse. J Am Vet Med Assoc 1976, 169:1098-1100.
86. Matsuoka T, Novilla MN, Thomson TD, Donoho AL Review of monensin toxicosis in horses. J Equine Vet Sci 1996, 16:8-15.
87. Mazlum Z, Pickles RW, Pradella G, Pagnani R Interaction between monensin, narasin, or salinomycin and the antibiotics erythromycin, chloramphenicol, or tylosin in broiler chicks. La Clinica Veterinaria 1985, 108:95-104.
88. Meingassner JG, Schmook FP, Czok R, Mieth H Enhancement of the anticoccidial activity of polyether antibiotics in chickens by tiamulin. Poult Sci 1979, 58:308-313.
89. Meldrum JB, Evans RD, Robertson JL, Watkins KL, Novilla MN Alterations in levels of various antioxidant factors in turkey knockdown syndrome. Avian Dis 2000, 44:891-895.
90. Mehlhorn H, Pooch H, Raether W The action of polyether ionophorous antibiotics (monensin, salinomycin, lasalocid) on developmental stages of Eimeria tenella (Coccidia, Sprozoa) in vivo. Z Parasitenkd 1983, 69:457-471.
91. Meral I, Hsu W, Hembrough FB Digoxin-and monensininduced changes of intracellular Ca2_ concentration in guineapig ventricular myocyte. J Vet Med A 2002, 49:329-333.
92. Miller DJS, O'Connor JJ, Roberts NL Tiamulin/salinomycin interactions in pigs. Vet Rec 1986, 118:73-75.
93. Mitema ES, Sangiah S, Martin T Effects of some calcium modulators on monensin toxicity. Vet Hum Toxicol 1988, 30:409-413.
94. Mollenhauer HH, Rowe LD, Cysewski SJ, Witzel DA Ultrastructural observations in ponies after treatment with monensin. Am J Vet Res 1981, 42:35-40.
95. Mollenhauer HH, Rowe LD, Witzel DA Effect of monensin on the morphology of mitochondria in rodent and equine striated muscle. Vet Hum Toxicol 1984, 26:15-19.
96. Mollenhauer HH, Morre DJ, Rowe RD Alteration of intracellular traffic by monensin, mechanism, specificity and relationship to toxicity. Biochim Biophys Acta 1990, 1031:225-246.
97. Mubagwa K, Lin W, Sipido K, Bosteels S, Flameng W Monensininduced reversal of positive force-frequency relationship in cardiac muscle, role of intracellular sodium in reas-dependent potentiation of contractio. J Mol Cell Cardiol 1997, 29:977-989.
98. Muylle E, Vandenhende C, Oyaert W, Thoonen H, Vlaeminck K Delayed monensin sodium toxicity in horses. Equine Vet J 1981, 13:107-108.
99. Nagaraja TG, Avery TB, Bartley EE, Roof SK, Dayton AD Effect of lasalocid, monensin and thiopeptin on lactic acidosis in cattle. J Anim Sci 1982, 54:649-658.
100. Nation PN, Crowe SP, Harries WN Clinical signs and pathology of accidental monensin poisoning in sheep. Can Vet J 1982, 23:323-326.
101. Nebbia C, Ceppa L, Dacasto M, Carletti M, Nachtmann C Evidence for CYP3A involvement in the hepatic microsomal metabolism of monensin. J Vet Pharmacol Therap 1997, 20(Suppl. 1):89-90.
102. Nebbia C, Ceppa L, Dacasto M, Nachtmann C, Carletti M Oxidative monensin metabolism and cytochrome P4503 A content and functions in liver microsomes from horses, pigs, broiler chicks, cattle and rats. J Vet Pharmacol Therap 2001, 24:399-403.
103. Newsholme SJ, Howerth EW, Bastianello SS, Prozesky L, Minne JA Fatal cardiomyopathy in feedlot sheep attributed to monensin toxicosis. J South Afr Vet Assoc 1983, 54:29-32.
104. Nocerini MR, Honeyfield DC, Carlson JR, Breeze RG Reduction in 3-methylindole production and prevention of acute bovine pulmonary edema and emphysema with lasalocid. J Anim Sci 1985, 60:232-238.
105. Novilla MN The veterinary importance of the toxic syndrome induced by ionophores. Vet Hum Toxicol 1992, 34:66-70.
106. Novilla MN Expert report on the safety file for monensin sodium 2004, Submitted to the European Medicines Agency CVMP by Elanco Animal Health, Division of Eli Lilly and Company, Indianapolis, USA.
107. Novilla MN, Folkerts TM Ionophores, monensin, lasalocid, salinomycin, narasin. Current Veterinary Therapy-Food Animal Practice 1986, 359-363. Academic Press, New York. J.L. Howard (Ed.).
108. Novilla MN, Todd GC Cardiotoxicity of the ionophores rat. Monographs on Pathology of Laboratory Animals Cardiovascular and Musculoskeletal Systems 1991, Springer Verlag, Berlin. T.C. Jones, U. Mohr, R.D. Hunt (Eds.).
109. Novilla MN, Owen NV, Todd GC The comparative toxicology of narasin in laboratory animals. Vet Hum Toxicol 1994, 36:318-323.
110. Oehme F, Pickrell J An analysis of the chronic oral toxicity of polyether ionophore antibiotics. Vet Hum Toxicol 1997, 41:251-257.
111. Ordidge RM, Schubert FK, Stoker JW Death of horses after accidental feeding of monensin. Vet Rec 1979, 104:375.
112. Osborne MW, Wenger JJ, Zanko MT The cardiovascular pharmacology of the antibioticionophore Ro2-2985 (X537A). J Pharmacol Exp Ther 1977, 200:195-205.
113. Parker RJ, Jones GW, Ellis KJ, Heater KM, Schroter KL, Tyler R, Holroyd RG Post-weaning coccidiosis in beef calves in the dry tropics, experimental control with continuous monensin supplementation via intraruminal devices and concurr. Trop Anim Hlth Prod 1986, 18:198-208.
114. Peek SF, Marques FD, Morgan J, Steiberg H, Zoromski DW, McGuirk S Atypical acute monensin toxicosis and delayed cardiomyopathy in Belgian draft horses. J Vet Intern Med 2004, 18:761-764.
115. Perelman B, Perak M, Smith B Effect of accidental feeding of lasalocid sodium in broiler breeder chickens. Vet Rec 1993, 132:271-273.
116. Pott JM, Skov B Monensin/tiamulin interactions in pigs. Vet Rec 1981, 109:545.
117. Potter EL, Van Duyn RL, Cooley CO Monensin toxicity in cattle. J Anim Sci 1984, 58:1499-1511.
118. Plumlee KH, Johnson B, Galey FD Acute salinomycin toxicosis of pigs. J Vet Diagn Invest 1995, 7:419-420.
119. Pressman BC Biological applications of ionophores. Annu Rev Biochem 1976, 45:501-530.
120. Pressman BC, Fahim NI Pharmacology and toxicology of the monovalent carboxytic ionophores. Annu Rev Pharmacol Toxicol 1982, 22:465-490.
121. Pressman BC, Fahim NI Cardiovascular toxicity of ionophores used as feed additives. Adv Exp Md Biol 1983, 161:543-561.
122. Reed PW Biochemical and biological effects of carboxylic acid ionophores. Polyether Antibiotics 1982, 205-302. Marcel Dekker, New York. J.W. Westley (Ed.).
123. Reed PW, Bokoch GM Cardiovascular and renal effects of A23187 and monovalent polyether antibiotics. Polyether Antibiotics 1982, 369-395. Marcel Dekker, New York. J.W. Westley (Ed.).
124. Reichenback DD, Benditt EP Catecholamines and cardiomyopathy, the pathogenesis and potential importance of myofibrillar degeneration. Human Pathol 1982, 1:125-150.
125. Richardson LF, Raun AP, Potter EL, Cooley CO, Rathmacher RP Effect of monensin on rumen fermentation in vitro and in vivo. J Anim Sci 1976, 43:1501-1508.
126. Riddell FG Structure, conformation, and mechanism in the membrane transport of alkali metal ions by ionophoric antibiotics. Chirality 2002, 14:121-125.
127. Rollinson J, Taylor FGR, Cheeney J Salinomycin poisoning in horses. Vet Rec 1987, 121:126-128.
128. Ruff MD Veterinary applications. Polyether Antibiotics 1982, 303-367. Marcel Dekker, New York. J.W. Westley (Ed.).
129. Russell JB A proposed mechanism of monensin action in inhibiting ruminal bacterial growth, effects on ion flux and protonmotive force. J Anim Sci 1987, 64:1519-1525.
130. Russell JB, Strobel HJ Mini-review, effect of ionophores on ruminal fermentation. Appl Environ Microbiol 1989, 55:1-6.
131. Saini RK, Hester RK, Somani P, Pressman BC Characterization of the coronary vasodilator and hemodynamic actions of monensin, a carboxylic ionophore. J Cardiovasc Pharmacol 1979, 1:123-138.
132. Safran N, Aisenberg I, Bark H Paralytic syndrome attributed to laslocid residues in a commercial ration fed to dogs. J Am Vet Med Assoc 1993, 202:1273-1275.
133. Salles MS, Lombardo de Barros CS, Barros SS Ionophore antibiotic (narasin) poisoning in rabbits. Vet Hum Toxicol 1994, 36:437-444.
134. Salyi G, Szabo E, Bago G, Banhidi G, Szilagyi M Narasin poisoning in turkeys. Acta Vet Hung 1988, 36:107-114.
135. Sandercock DA, Mitchell MA Myopathy in broiler chickens, a role for Ca2_-activated phospholipase A2?. Poult Sci 2003, 82:1307-1312.
136. Sandercock DA, Mitchell MA The role of sodium ions in the pathogenesis of skeletal muscle damage in broiler chickens. Poultry Sci 2004, 83:701-706.
137. Segev G, Baneth G, Levitin B, Shlosberg A, Aroch I Accidental poisoning of 17 dogs with lasalocid. Vet Rec 2004, 135:174-176.
138. Schweitzer D, Kimberling C, Spraker T, Sterner FE, McChesney AE Accidental monensin sodium intoxication in feedlot cattle. J Am Vet Med Assoc 1984, 184:1273-1276.
139. Shier WT, DuBourdieu DJ Sodium-and calcium-dependent steps in the mechanism of neonatal rat cardiac myocyte killing by ionophores. Toxicol Appl Pharmacol 1992, 116:38-46.
140. Shaik MS, Ikediobi O, Turnage VD, McSween J, Kanikkannan N, Singh M Long-circulating monensin nanoparticles for the potentiation of immunotoxin and anticancer drugs. J Pharm Pharmacol 2001, 53:617-627.
141. Shlosberg A, Weisman Y, Klopper U, Perl S Neurotoxic action of lasalocid at high doses. Vet Rec 1985, 117:394.
142. Shlosberg A, Harmelin A, Perl S, Pano G, Davidson M, Orgad U, Kali U, Bor A, Van Ham M, Hoida G, Yakobson B, Avidar Y, Isaeli B-A, Bogin E Cardiomyopathy in cattle induced by residues of the coccidistat maduramycin in poultry litter given as a feedstuff. Vet Res Commun 1992, 16:45-58.
143. Siller WG Deep pectoral myopathy, a penalty of successful selection for muscle growth. Poultry Sci 1985, 64:1591-1595.
144. Simpson CF, Damron BL, Harms RH Toxic myopathy of chicks fed Cassia occidentalis seeds. Avian Dis 1971, 15:284-290.
145. Singal PK, Yates JC, Beamish RE, Beamish NS Influence of reducing agents on adrenochrome-induced changes in the heart. Arch Pathol Lab Med 1981, 105:664-669.
146. Smith CK, Galloway RG Influence of monensin on cation influx and glycolysis of Eimeria tenella sporozoites in vitro. J Parasitol 1983, 69:666-670.
147. Smith II CK, Strout RG Eimeria tenella, accumulation and retention of anticoccidial ionophores by extracellular sporozoites. Exp Parasitol 1979, 48:325-330.
148. Smith II CK, Strout RG Eimeria tenella, effect of narasin, a polyether antibiotic on the ultrastructure of intracellular sporozoites. Exp Parasitol 1980, 50:426-436.
149. Smith CK, Galloway RB, White SL Effect of ionophores on survival, penetration, and development of Eimeria tenella sporozoites. in vitro. J Parasitol 1981, 67:511-516.
150. Stanfield DG, Lamont MN Monensin-tiamulin interactions in pigs. Vet Rec 1981, 109:545.
151. Stockdale PHG Effects of monensin on coccidiosis in ruminants. Vet Med Small Anim Clin 1981, 1575-1578.
152. Stuart JC An outbreak of monensin poisoning in adult turkeys. Vet Rec 1978, 102:303-304.
153. Sutko JL, Besch Jr HR, Bailey JC, Zimmerman G, Watanabe AM Direct effects of the monovalent cation ionophores monensin and nigericin on myocardium. J Pharmacol Exp Therap 1977, 203:685-700.
154. Swayne DE, Shlosberg A, Davis RB Salt poisoning in turkey poults. Avian Dis 1986, 30:814-852.
155. Szücs G, Tamasi V, Laczay P, Monostory K Biochemical background of toxic interaction between tiamulin and monensin. Chemico-biological interactions 2004, 147:151-161.
156. Taylor RW, Kauffman RF, Pfeifer DR Cation complexation and transport by carboxylic acid ionophores. Polyether Antibiotics 1982, 103-184. Marcel Dekker, New York. J.W. Westley (Ed.).
157. Tappel AL Vitamin E and selenium protection from to vitro lipid peroxidation. Ann NY Acad Sci 1981, 355:18-31.
158. Thomas EE, Smith CK, McGuffey RK, Quinn ME Monensin provides coccidiosis control, site and mode of action. Tech Talk Scientific Update from Elanco Animal Health 1985, A Division of Eli Lilly and Company, Indianapolis, USA.
159. Todd GC, Meyers DB, Pierce EC, Worth HM Acute reversible myopathy produced by compound A204. Antimicrob Agents Chemother 361-5. 1970.
160. Todd OC, Novilla MN, Howard LC Comparative toxicology of monensin sodium in laboratory animals. J Anim Sci 1984, 58:1512-1517.
161. Trump BF, Berezesky IK, Smith MW, Phelps PC, Elliget KA The relationship between cellular ion deregulation and acute and chronic toxicity. Toxicol Appl Pharmacol 1989, 97:6-22.
162. Tsuchida K, Otomo S Electrophysiological effects of monensin, a sodium ionophore, on cardiac Purkinje fibers. Eur J Pharmacol 1990, 190:313-320.
163. Umemura T, Nakamura H, Goryo M, Itakura C Ultrastructural changes of monensin-oleandomycin myopathy in broiler chicks. Avian Pathol 1984, 13:743-751.
164. Umemura T, Nakamura H, Goryo M, Itakura C Ultrastructural changes of monensin oleandomycin myopathy in broiler chicks. Avian Pathol 1995, 13:743-751.
165. Van Halderen A, Bastianello SS, Fourie N, Zumpt IF An outbreak of narasin poisoning in swine. J South Afr Vet Assoc 1993, 64:43-46.
166. Van der Linde-Sipman JS, Van den Ingh TSGAM, Van Es JJ, Verhagen H, Kersten JGTM, Beynen AC, Plekkringa R Salinomycininduced polyneuropathy in cats, morphologic and epidemiologic data. Vet Pathol 1999, 36:152-156.
167. Van Vleet JF Interactions of nutritional status and ionophore feed additives in animals. Proceedings of 6th International Conference on Production Diseases in Farm Animals 1986, 268-276. Belfast, Northern Ireland.
168. Van Vleet JF, Ferrans VJ Ultrastructural myocardial alterations in monensin toxicosis of cattle. Am J Vet Res 1983, 44:1629-1636.
169. Van Vleet JF, Ferrans VJ Ultrastructural alterations in skeletal muscle of pigs with acute monensin toxicosis. Vet Pathol 1984, 114:461-471.
170. Van Vleet JF, Amstutz HE, Weirich WE, Rebar AH, Ferrans VJ Acute monensin toxicosis in swine, effect of graded doses of monensin and protection of swine by pretreatment with selenium-vitamin E. Am J Vet Res 1983, 44:1460-1468.
171. Van Vleet JF, Amstutz HE, Weirich WE, Rebar AH, Ferrans VJ Clinical clinicopathological and pathologic alterations of acute monensin toxicosis in swine. Am J Vet Res 1983, 44:1469-1475.
172. Van Vleet JF, Amstutz HE, Weirich WE, Rebar AH, Ferrans VJ Clinical, clinicopathologic and pathologic alterations in acute monensin toxicosis in cattle. Am J Vet Res 1983, 44:2133-2144.
173. Van Vleet JF, Runnels LJ, Cook JR, Scheidt AB Monensin toxicosis in swine, potentiation by tiamulin administration and ameliorative effect of treatment with selenium and/or vitamin E. Am J Vet Res 1987, 48:1520-1523.
174. Van Vleet JF, Amstutz HE, Rebar AH Effect of pretreatment with selenium-vitamin E on monensin toxicosis in cattle. Am J Vet Res 1985, 46:2221-2228.
175. Van Vleet JF, Ferrans VJ, Herman E Cardiovascular and skeletal muscle system. Handbook of Toxicologic Pathology 1991, 539-624. Academic Press, San Diego, CA. W.M. Hascheck, C.G. Rousseaux (Eds.).
176. Wages DP Turkey knockdown is a multi-faceted puzzle. Turkey World 1993, 69:24-25.
177. Wages DP, Ficken MD Skeletal muscle lesions in turkeys associated with the feeding of monensin. Avian Dis 1988, 32:583-586.
178. Wanner M Unvertraglichkeit von Tiamulin und Salinomycin beim Schwein, Schweiz. Arch Tierheilk 1984, 126:521-526.
179. Weisman J, Herz A, Jegana J, Egyed M, Shlosberg A The effect of tiamulin administered by different routes and at different ages in turkeys receiving monensin in their feed. Vet Res Comm 1983, 6:189-198.
180. Weisman J, Shkap I, Egyed M, Shlosberg A Chloramphenicol induced monensin toxicity. Refuah Vet 1984, 41:3-6.
181. Weisman J, Shlosberg A, Egyed M Acute poisoning in turkeys caused by incompatibility of monensin and tiamulin. Vet Res Comm 1980, 4:231-235.
182. Whitlock RH, White NA, Rowland GN, Plue R Monensin toxicosis in horses; clinical manifestations. Proc Am Assoc Equine Practnrs 1978, 24:473-486.
183. Wilson JS Toxic myopathy in a dog associated with the presence of monensin in dry food. Can Vet J 1980, 21:30-31.
184. Wilson BW, Nieberg PS, Buhr RJ, Kelley BJ, Shultz FT Turkey muscle growth and focal myopathy. Poult Sci 1990, 69:1553-1562.
185. Witkamp RP, Nijmeijer SM, Monshouwer M, Van Miert ASJPAM The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P450 A via the formation of a stable metabolic intermediate complex. Drug Metab Dispos 1995, 23:542-547.
186. Witkamp RP, Nijmeijer SM, Van Miert ASJPAM Cytochrome P450 complex formation in rat liver by the antibiotic tiamulin. Antimicrob Agents Chemother 1996, 40:50-54.
187. Yates JC, Beamish RF, Dhalla NS Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine, relation to pathogenesis of catecholamine cardiomyopathy. Am Heart J 1981, 102:210-221.