Blood Cell Salvage and Autotransfusion Does Not Worsen Oncologic Outcomes Following Liver Transplantation with Incidental Hepatocellular Carcinoma: A Propensity Score-Matched Analysis

Annals of Surgical Oncology

Volumn 28, Issue 11, 2021, Pages 6816-6825

  Ivanics, Tommy ^a,b   Shubert, Christopher R ^c   Muaddi, Hala ^a   Claasen, Marco P A W ^a,d   Yoon, Peter ^a   Hansen, Bettina E ^e   McCluskey, Stuart A ^a,f   Sapisochin, Gonzalo ^a  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b HENRY FORD HOSPITAL   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLOOD AUTOTRANSFUSION; BLOOD CELL; BLOOD SALVAGE; CANCER RECURRENCE; CLINICAL OUTCOME; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY RISK; OVERALL SURVIVAL; PROPENSITY SCORE; RECURRENCE RISK; RETROSPECTIVE STUDY; LIVER TUMOR; RISK FACTOR; TUMOR RECURRENCE;

BLOOD CELLS; BLOOD TRANSFUSION, AUTOLOGOUS; CARCINOMA, HEPATOCELLULAR; HUMANS; LIVER NEOPLASMS; LIVER TRANSPLANTATION; NEOPLASM RECURRENCE, LOCAL; PROPENSITY SCORE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 85103195090     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-021-09863-6     Document Type: Article

References (41)

1. Makino Y, Yamanoi A, Kimoto T, El-Assal ON, Kohno H, Nagasue N. The influence of perioperative blood transfusion on intrahepatic recurrence after curative resection of hepatocellular carcinoma. Am J Gastroenterol. 2000;95(5):1294–300. 10.1016/S0002-9270(00)00820-0. DOI: 10.1016/S0002-9270(00)00820-0
2. Harada N, Shirabe K, Maeda T, Kayashima H, Ishida T, Maehara Y. Blood transfusion is associated with recurrence of hepatocellular carcinoma after hepatectomy in Child-Pugh class a patients. World J Surg. 2015;39(4):1044–51. 10.1007/s00268-014-2891-6. DOI: 10.1007/s00268-014-2891-6
3. Phillips SD, Maguire D, Deshpande R, et al. A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation. Transplantation. 2006;81(4):536–40. 10.1097/01.tp.0000199318.17013.c5. DOI: 10.1097/01.tp.0000199318.17013.c5
4. Mazzaferro V, Regalia E, Doci R, et al. Carcinomas in patients with cirrhosis. N Engl J Med. 1996;334(11):693–9. 10.1056/NEJM199603143341104. DOI: 10.1056/NEJM199603143341104
5. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334(11):693–9. 10.1056/nejm199603143341104. DOI: 10.1056/nejm199603143341104
6. Sposito C, Cucchetti A, Mazzaferro V. Assessing competing risks for death following liver transplantation for hepatocellular carcinoma. Dig Dis Sci. 2019;64(4):1001–7. 10.1007/s10620-019-05538-1. DOI: 10.1007/s10620-019-05538-1
7. Han S, Kim G, Ko JS, et al. Safety of the use of blood salvage and autotransfusion during liver transplantation for hepatocellular carcinoma. Ann Surg. 2016;264(2):339–43. 10.1097/SLA.0000000000001486. DOI: 10.1097/SLA.0000000000001486
8. Akbulut S, Kayaalp C, Yilmaz M, et al. Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients. World J Gastroenterol. 2013;19(10):1625–31. 10.3748/wjg.v19.i10.1625. DOI: 10.3748/wjg.v19.i10.1625
9. Kim JM, Kim GS, Joh JW, et al. Long-term results for living donor liver transplant recipients with hepatocellular carcinoma using intraoperative blood salvage with leukocyte depletion filter. Transpl Int. 2013;26(1):84–9. 10.1111/tri.12001. DOI: 10.1111/tri.12001
10. Muscari F, Suc B, Vigouroux D, et al. Blood salvage autotransfusion during transplantation for hepatocarcinoma: Does it increase the risk of neoplastic recurrence? Transpl Int. 2005;18(11):1236–9. 10.1111/j.1432-2277.2005.00207.x. DOI: 10.1111/j.1432-2277.2005.00207.x
11. Araujo RL, Pantanali CA, Haddad L, Filho JAR, D’Albuquerque LAC, Andraus W. Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence? World J Gastrointest Surg. 2016;8(2):161. 10.4240/wjgs.v8.i2.161. DOI: 10.4240/wjgs.v8.i2.161
12. Lyon TD, Ferroni MC, Turner RM 2nd, Jones C, Jacobs BL, Davies BJ. Short-term outcomes of intraoperative cell saver transfusion during open partial nephrectomy. Urology. 2015;86(6):1153–8. 10.1016/j.urology.2015.09.008. DOI: 10.1016/j.urology.2015.09.008
13. Davis M, Sofer M, Gomez-Marin O, Bruck D, Soloway MS. The use of cell salvage during radical retropubic prostatectomy: does it influence cancer recurrence? BJU Int. 2003;91(6):474–6. 10.1046/j.1464-410x.2003.04129.x. DOI: 10.1046/j.1464-410x.2003.04129.x
14. Connor JP, Morris PC, Alagoz T, Anderson B, Bottles K, Buller RE. Intraoperative autologous blood collection and autotransfusion in the surgical management of early cancers of the uterine cervix. Obstet Gynecol. 1995;86(3):373–8. 10.1016/0029-7844(95)00183-R. DOI: 10.1016/0029-7844(95)00183-R
15. Zacharias T, Ahlschwede E, Dufour N, Romain F, Theissen-Laval O. Intraoperative cell salvage with autologous transfusion in elective right or repeat hepatectomy: a propensity-score-matched case-control analysis. Can J Surg. 2018;61(2):105–13. 10.1503/cjs.010017. DOI: 10.1503/cjs.010017
16. Kitagawa K, Taniguchi H, Mugitani T, et al. Safety and advantage of perioperative autologous blood transfusion in hepatic resection for hepatocellular carcinoma. Anticancer Res. 2001;21(5):3663–7.
17. Edmondson HA, Steiner PE. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954;7(3):462–503. 10.1002/1097-0142(195405)7:3%3c462::aid-cncr2820070308%3e3.0.co;2-e. DOI: 10.1002/1097-0142(195405)7:3<462::aid-cncr2820070308>3.0.co;2-e
18. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344–9. 10.1016/j.jclinepi.2007.11.008. DOI: 10.1016/j.jclinepi.2007.11.008
19. Eghbal MH, Samadi K, Khosravi MB, et al. The impact of preoperative variables on intraoperative blood loss and transfusion requirements during orthotopic liver transplant. Exp Clin Transpl. 2019;17(4):507–12. 10.6002/ect.2016.0325. DOI: 10.6002/ect.2016.0325
20. Sobreira Fernandes D, Pereira Real CC, Sá Couto Romão PA, et al. Pre-operative predictors of red blood cell transfusion in liver transplantation. Blood Transfus. 2017;15(1):53–6. 10.2450/2016.0203-15. DOI: 10.2450/2016.0203-15
21. Steib A, Freys G, Lehmann C, Meyer C, Mahoudeau G. Intraoperative blood losses and transfusion requirements during adult liver transplantation remain difficult to predict. Can J Anaesth. 2001;48(11):1075–9. 10.1007/BF03020372. DOI: 10.1007/BF03020372
22. Mangus RS, Kinsella SB, Nobari MM, et al. Predictors of blood product use in orthotopic liver transplantation using the piggyback hepatectomy technique. Transplant Proc. 2007;39(10):3207–13. 10.1016/j.transproceed.2007.09.029. DOI: 10.1016/j.transproceed.2007.09.029
23. Triulzi DJ. Transfusion support in liver transplantation. Curr Hematol Rep. 2004;3(6):444–9.
24. Massicotte L, Sassine M-P, Lenis S, Roy A. Transfusion predictors in liver transplant. Anesth Analg. 2004;98(5):1245–51. 10.1213/01.ane.0000111184.21278.07. DOI: 10.1213/01.ane.0000111184.21278.07
25. De Santis GC, Brunetta DM, Nardo M, et al. Preoperative variables associated with transfusion requirements in orthotopic liver transplantation. Transfus Apher Sci. 2014;50(1):99–105. 10.1016/j.transci.2013.10.006. DOI: 10.1016/j.transci.2013.10.006
26. Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivar Behav Res. 2011;46(3):399–424. 10.1080/00273171.2011.568786. DOI: 10.1080/00273171.2011.568786
27. Austin PC. Using the standardized difference to compare the prevalence of a binary variable between two groups in observational research. Commun Stat Simul Comput. 2009;38(6):1228–34. 10.1080/03610910902859574. DOI: 10.1080/03610910902859574
28. Hansen E, Wolff N, Knuechel R, Ruschoff J, Hofstaedter F, Taeger K. Tumor cells in blood shed from the surgical field. Arch Surg. 1995;130(4):387–93. 10.1001/archsurg.1995.01430040049007. DOI: 10.1001/archsurg.1995.01430040049007
29. Gwak MS, Lee KW, Kim SY, et al. Can a leukocyte depletion filter (LDF) reduce the risk of reintroduction of hepatocellular carcinoma cells? Liver Transplant. 2005;11(3):331–5. 10.1002/lt.20346. DOI: 10.1002/lt.20346
30. Foltys D, Zimmermann T, Heise M, et al. Liver transplantation for hepatocellular carcinoma–is there a risk of recurrence caused by intraoperative blood salvage autotransfusion? Eur Surg Res. 2011;47(3):182–7. 10.1159/000330746. DOI: 10.1159/000330746
31. Abdelfattah MR, Abaalkhail F, Al-Manea H. Misdiagnosed or incidentally detected hepatocellular carcinoma in explanted livers: Lessons learned. Ann Transplant. 2015;20:366–72. 10.12659/AOT.893782. DOI: 10.12659/AOT.893782
32. Pérez P, Rodriguez-Peralvarez M, Guerrero L, et al. Incidental hepatocellular carcinoma after liver transplantation: Prevalence, histopathological features and prognostic impact. PLoS ONE. 2017;12(4):e0175010. 10.1371/journal.pone.0175010. DOI: 10.1371/journal.pone.0175010
33. Sotiropoulos GC, Malago M, Molmenti EP, et al. Liver transplantation and incidentally found hepatocellular carcinoma in liver explants: need for a new definition? Transplantation. 2006;81(4):531–5. 10.1097/01.tp.0000198739.42548.3e. DOI: 10.1097/01.tp.0000198739.42548.3e
34. Goldaracena N, Mehta N, Scalera I, et al. Multicenter validation of a score to predict prognosis after the development of HCC recurrence following liver transplantation. HPB. 2019;21(6):731–8. 10.1016/j.hpb.2018.10.005. DOI: 10.1016/j.hpb.2018.10.005
35. Hong SK, Lee K-W, Yoon KC, et al. Different prognostic factors and strategies for early and late recurrence after adult living donor liver transplantation for hepatocellular carcinoma. Clin Transplant. 2019;33(10):e13703. 10.1111/ctr.13703. DOI: 10.1111/ctr.13703
36. Cata JP, Wang H, Gottumukkala V, Reuben J, Sessler DI. Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth. 2013;110(5):690–701. 10.1093/bja/aet068. DOI: 10.1093/bja/aet068
37. Vamvakas EC. Deleterious clinical effects of transfusion immunomodulation: proven beyond a reasonable doubt. Transfusion. 2006;46(3):492–5. 10.1111/j.1537-2995.2006.00748.x. DOI: 10.1111/j.1537-2995.2006.00748.x
38. Kindscher J. Blood usage in a newly organized liver transplant program. Transplant Proc. 1993;25(2):1823.
39. Massicotte L, Denault AY, Beaulieu D, et al. Transfusion rate for 500 consecutive liver transplantations: experience of one liver transplantation center. Transplantation. 2012;93(12):1276–81. 10.1097/TP.0b013e318250fc25. DOI: 10.1097/TP.0b013e318250fc25
40. Kuroda S, Tashiro H, Kobayashi T, Oshita A, Amano H, Ohdan H. No impact of perioperative blood transfusion on recurrence of hepatocellular carcinoma after hepatectomy. World J Surg. 2012;36(3):651–8. 10.1007/s00268-012-1425-3. DOI: 10.1007/s00268-012-1425-3
41. Yang T, Lu JH, Lau WY, et al. Perioperative blood transfusion does not influence recurrence-free and overall survivals after curative resection for hepatocellular carcinoma: a propensity score matching analysis. J Hepatol. 2016;64(3):583–93. 10.1016/j.jhep.2015.10.012. DOI: 10.1016/j.jhep.2015.10.012