Association between postoperative haemoglobin concentrations and composite of non-fatal myocardial infarction and all-cause mortality in noncardiac surgical patients: post hoc analysis of the POISE-2 trial

British Journal of Anaesthesia

Volumn 126, Issue 1, 2021, Pages 87-93

  Turan, Alparslan ^a   Rivas, Eva ^a,b   Devereaux, Philip J ^c,d,e   Bravo, Mauro ^a   Mao, Guangmei ^a   Cohen, Barak ^a,f   Maheshwari, Kamal ^a   Pu, Xuan ^a   Ruetzler, Kurt ^a   Li, Kai ^a,g   Sessler, Daniel I ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

^c HAMILTON HEALTH SCIENCES   (Canada)

^d Department of Clinical Epidemiology and Biostatistics ^*  (Canada)

^e MCMASTER UNIVERSITY   (Canada)

^f TEL AVIV UNIVERSITY   (Israel)

^g CHINA JAPAN UNION HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

anaemia; anaesthesia; cardiovascular risk; haemoglobin; myocardial infarction; postoperative outcomes risk; surgery

Indexed keywords

HEMOGLOBIN;

ADULT; AGED; ALL CAUSE MORTALITY; ARTICLE; FEMALE; HEART INFARCTION; HEMOGLOBIN DETERMINATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURGICAL PATIENT; ANEMIA; BLOOD; CAUSALITY; MIDDLE AGED; POSTOPERATIVE COMPLICATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANEMIA; CAUSALITY; FEMALE; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES;

EID: 85091610146     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1016/j.bja.2020.08.054     Document Type: Article

References (29)

1. Weiser, T.G., Haynes, A.B., Molina, G., et al. Estimate of the global volume of surgery in 2012: an assessment supporting improved health outcomes. Lancet, 385, 2015, S11.
2. Abbott, T.E.F., Pearse, R.M., Archbold, R.A., et al. A Prospective international multicentre cohort study of intraoperative heart rate and systolic blood pressure and myocardial injury after noncardiac surgery. Anesth Analg 126 (2018), 1936–1945.
3. Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators, Devereaux, P.J., Chan, M.T.V., Alonso-Coello, P., et al. Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery. JAMA 307 (2012), 2295–2304.
4. Writing Committee for the VISION Study Investigators Devereaux, P.J., Biccard, B.M., Sigamani, A., et al. Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery. JAMA 317 (2017), 1642–1651.
5. Botto, F., Alonso-Coello, P., Chan, M.T.V., et al. Myocardial injury after noncardiac surgery. Anesthesiology 120 (2014), 564–578.
6. Khan, J., Alonso-Coello, P., Devereaux, P.J., Myocardial injury after noncardiac surgery. Curr Opin Cardiol 29 (2014), 307–311.
7. Abbott, T.E.F., Fowler, A.J., Dobbs, T.D., Harrison, E.M., Gillies, M.A., Pearse, R.M., Frequency of surgical treatment and related hospital procedures in the UK: a national ecological study using hospital episode statistics. Br J Anaesth 119 (2017), 249–257.
8. Devereaux, P.J.J., Mrkobrada, M., Sessler, D.I., et al. Aspirin in patients undergoing noncardiac surgery. N Engl J Med 370 (2014), 1494–1503.
9. Devereaux, P.J., Sessler, D.I., Leslie, K., et al. Clonidine in patients undergoing noncardiac surgery. N Engl J Med 370 (2014), 1504–1513.
10. Devereaux, P.J., Xavier, D., Pogue, J., et al. Characteristics and short-term prognosis of perioperative myocardial infarction in patients undergoing noncardiac surgery: a cohort study. Ann Intern Med 154 (2011), 523–528.
11. Salmasi, V., Maheshwari, K., Yang, D., et al. Relationship between intraoperative hypotension, defined by either reduction from baseline or absolute thresholds, and acute kidney and myocardial injury after noncardiac surgery: a retrospective cohort analysis. Anesthesiology 126 (2017), 47–65.
12. Walsh, M., Devereaux, P.J., Garg, A.X., et al. Relationship between intraoperative mean arterial pressure and clinical outcomes after noncardiac surgery. Anesthesiology 119 (2013), 507–515.
13. Carson, J.L., Duff, A., Poses, R.M., et al. Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 348 (1996), 1055–1060.
14. Musallam, K.M., Tamim, H.M., Richards, T., et al. Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 378 (2011), 1396–1407.
15. Spinelli, E., Bartlett, R.H., Anemia and transfusion in critical care. J Intensive Care Med 31 (2016), 295–306.
16. Docherty, A.B., O'Donnell, R., Brunskill, S., et al. Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis. BMJ, 352, 2016, i1351.
17. Mueller, M.M., Van Remoortel, H., Meybohm, P., et al. Patient blood management: recommendations from the 2018 Frankfurt Consensus Conference. JAMA 321 (2019), 983–997.
18. Carson, J.L., Guyatt, G., Heddle, N.M., et al. Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage. JAMA 316 (2016), 2025–2035.
19. Carson, J.L., Brooks, M.M., Abbott, J.D., et al. Liberal versus restrictive transfusion thresholds for patients with symptomatic coronary artery disease. Am Heart J 165 (2013), 964–971.e1.
20. Turan, A., Cohen, B., Rivas, E., et al. Association between postoperative haemoglobin and myocardial injury after noncardiac surgery: a retrospective cohort analysis. Br J Anaesth, 2020, 10.1016/j.bja.2020.08.056.
21. Thygesen, K., Alpert, J.S., Jaffe, A.S., et al. Third universal definition of myocardial infarction. Circulation 126 (2012), 2020–2035.
22. Carson, J.L., Terrin, M.L., Noveck, H., et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N Engl J Med 365 (2011), 2453–2462.
23. Cooper, H.A., Rao, S.V., Greenberg, M.D., et al. Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study). Am J Cardiol 108 (2011), 1108–1111.
24. Walsh, M., Srinathan, S.K., McAuley, D.F., et al. The statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index. J Clin Epidemiol 67 (2014), 622–628.
25. Grolleau, F., Collins, G.S., Smarandache, A., et al. The fragility and reliability of conclusions of anesthesia and critical care randomized trials with statistically significant findings: a systematic review. Crit Care Med 47 (2019), 456–462.
26. Sun, Z., Sessler, D.I., Dalton, J.E., et al. Postoperative hypoxemia is common and persistent: a prospective blinded observational study. Anesth Analg 121 (2015), 709–715.
27. Turan, A., Chang, C., Cohen, B., et al. Incidence, severity, and detection of blood pressure perturbations after abdominal surgery: a prospective blinded observational study. Anesthesiology 130 (2019), 550–559.
28. Yilmaz, H.O., Babazade, R., Leung, S., et al. Postoperative hypotension and surgical site infections after colorectal surgery. Anesth Analg 127 (2018), 1129–1136.
29. Mascha, E.J., Sessler, D.I., Design and analysis of studies with binary-event composite endpoints: guidelines for anesthesia research. Anesth Analg 112 (2011), 1461–1471.