Missing in Action: African Ancestry Brain Research

Neuron

Volumn 107, Issue 3, 2020, Pages 407-411

  Weinberger, Daniel R ^a   Dzirasa, Kafui ^b   Crumpton Young, Lesia L ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MORGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICA SOUTH OF THE SAHARA; AFRICAN AMERICAN; ARTICLE; BLACK PERSON; BRAIN DISEASE; DEGENERATIVE DISEASE; DISEASE PREDISPOSITION; DNA SEQUENCING; EPIGENETICS; GENE EXPRESSION PROFILING; GENETIC REGULATION; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE ENVIRONMENT INTERACTION; HEALTH CARE DISPARITY; HIGH RISK POPULATION; HUMAN; MENTAL DISEASE; MULTIOMICS; PERSONALIZED MEDICINE; POPULATION GENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RACE DIFFERENCE; RNA SEQUENCING; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIOECONOMICS; TRANSCRIPTOMICS; BRAIN; MEDICAL RESEARCH; NEUROSCIENCE; PATIENT SELECTION;

AFRICAN CONTINENTAL ANCESTRY GROUP; BIOMEDICAL RESEARCH; BRAIN; BRAIN DISEASES; HUMANS; NEUROSCIENCES; PATIENT SELECTION; PRECISION MEDICINE;

EID: 85088994770     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2020.07.008     Document Type: Note

References (10)

1. Bailey, Z.D., Krieger, N., Agénor, M., Graves, J., Linos, N., Bassett, M.T., Structural racism and health inequities in the USA: evidence and interventions. Lancet 389 (2017), 1453–1463.
2. Bentley, A.R., Callier, S.L., Rotimi, C.N., Evaluating the promise of inclusion of African ancestry populations in genomics. NPJ Genom. Med., 5, 2020, 5.
3. Bigdeli, T.B., Genovese, G., Georgakopoulos, P., Meyers, J.L., Peterson, R.E., Iyegbe, C.O., Medeiros, H., Valderrama, J., Achtyes, E.D., Kotov, R., et al. Consortium on the Genetics of Schizophrenia (COGS) Investigators, Genomic Psychiatry Cohort (GPC) Consortium. Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry. Mol. Psychiatry, 2019, 10.1038/s41380-019-0517-y Published online October 7, 2019.
4. Gandal, M.J., Zhang, P., Hadjimichael, E., Walker, R.L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., et al., PsychENCODE Consortium. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science, 362, 2018, eaat8127.
5. Gurdasani, D., Barroso, I., Zeggini, E., Sandhu, M.S., Genomics of disease risk in globally diverse populations. Nat. Rev. Genet. 20 (2019), 520–535.
6. Jaffe, A.E., Hoeppner, D.J., Saito, T., Blanpain, L., Ukaigwe, J., Burke, E.E., Collado-Torres, L., Tao, R., Tajinda, K., Maynard, K.R., et al. Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk. Nat. Neurosci. 23 (2020), 510–519.
7. Martin, A.R., Kanai, M., Kamatani, Y., Okada, Y., Neale, B.M., Daly, M.J., Clinical use of current polygenic risk scores may exacerbate health disparities. Nat. Genet. 51 (2019), 584–591.
8. Price, A.J., Collado-Torres, L., Ivanov, N.A., Xia, W., Burke, E.E., Shin, J.H., Tao, R., Ma, L., Jia, Y., Hyde, T.M., et al. Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation. Genome Biol., 20, 2019, 196.
9. Rajabli, F., Feliciano, B.E., Celis, K., Hamilton-Nelson, K.L., Whitehead, P.L., Adams, L.D., Bussies, P.L., Manrique, C.P., Rodriguez, A., Rodriguez, V., et al. Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS Genet., 14, 2018, e1007791.
10. Sherman, R.M., Forman, J., Antonescu, V., Puiu, D., Daya, M., Rafaels, N., Boorgula, M.P., Chavan, S., Vergara, C., Ortega, V.E., et al. Assembly of a pan-genome from deep sequencing of 910 humans of African descent. Nat. Genet. 51 (2019), 30–35.