-
1
-
-
85021849793
-
Canagliflozin slows progression of renal function decline independently of glycemic effects
-
Heerspink, HJL, Desai, M, Jardine, M, Balis, D, Meininger, G, Perkovic, V, Canagliflozin slows progression of renal function decline independently of glycemic effects. J Am Soc Nephrol 28 (2017), 368–375.
-
(2017)
J Am Soc Nephrol
, vol.28
, pp. 368-375
-
-
Heerspink, H.J.L.1
Desai, M.2
Jardine, M.3
Balis, D.4
Meininger, G.5
Perkovic, V.6
-
2
-
-
85060042753
-
Dapagliflozin and cardiovascular outcomes in type 2 diabetes
-
Wiviott, SD, Raz, I, Bonaca, MP, et al. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 380 (2019), 347–357.
-
(2019)
N Engl J Med
, vol.380
, pp. 347-357
-
-
Wiviott, S.D.1
Raz, I.2
Bonaca, M.P.3
-
3
-
-
84979895487
-
Empagliflozin and progression of kidney disease in type 2 diabetes
-
Wanner, C, Inzucchi, SE, Lachin, JM, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med 375 (2016), 323–334.
-
(2016)
N Engl J Med
, vol.375
, pp. 323-334
-
-
Wanner, C.1
Inzucchi, S.E.2
Lachin, J.M.3
-
4
-
-
85066483412
-
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
-
Perkovic, V, Jardine, MJ, Neal, B, et al. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med 380 (2019), 2295–2306.
-
(2019)
N Engl J Med
, vol.380
, pp. 2295-2306
-
-
Perkovic, V.1
Jardine, M.J.2
Neal, B.3
-
5
-
-
85067060766
-
Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE–TIMI 58 randomised trial
-
Mosenzon, O, Wiviott, SD, Cahn, A, et al. Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE–TIMI 58 randomised trial. Lancet Diabetes Endocrinol 7 (2019), 606–617.
-
(2019)
Lancet Diabetes Endocrinol
, vol.7
, pp. 606-617
-
-
Mosenzon, O.1
Wiviott, S.D.2
Cahn, A.3
-
6
-
-
85073746348
-
Effect of canagliflozin on renal and cardiovascular outcomes across different levels of albuminuria: data from the CANVAS program
-
Neuen, BL, Ohkuma, T, Neal, B, et al. Effect of canagliflozin on renal and cardiovascular outcomes across different levels of albuminuria: data from the CANVAS program. J Am Soc Nephrol 30 (2019), 2229–2242.
-
(2019)
J Am Soc Nephrol
, vol.30
, pp. 2229-2242
-
-
Neuen, B.L.1
Ohkuma, T.2
Neal, B.3
-
7
-
-
85073095324
-
SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis
-
Neuen, BL, Young, T, Heerspink, HJL, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol 7 (2019), 845–854.
-
(2019)
Lancet Diabetes Endocrinol
, vol.7
, pp. 845-854
-
-
Neuen, B.L.1
Young, T.2
Heerspink, H.J.L.3
-
8
-
-
85079017762
-
Evaluating the effects of canagliflozin on cardiovascular and renal events in patients with type 2 diabetes mellitus and chronic kidney disease according to baseline HbA1c, including those with HbA1c <7%: results from the CREDENCE trial
-
Cannon, C, Perkovic, V, Agarwal, R, et al. Evaluating the effects of canagliflozin on cardiovascular and renal events in patients with type 2 diabetes mellitus and chronic kidney disease according to baseline HbA1c, including those with HbA1c <7%: results from the CREDENCE trial. Circulation 141 (2020), 407–410.
-
(2020)
Circulation
, vol.141
, pp. 407-410
-
-
Cannon, C.1
Perkovic, V.2
Agarwal, R.3
-
9
-
-
84893214045
-
Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus
-
Cherney, DZI, Perkins, BA, Soleymanlou, N, et al. Renal hemodynamic effect of sodium-glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation 129 (2014), 587–597.
-
(2014)
Circulation
, vol.129
, pp. 587-597
-
-
Cherney, D.Z.I.1
Perkins, B.A.2
Soleymanlou, N.3
-
10
-
-
85075994597
-
The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial
-
van Bommel, EJM, Muskiet, MHA, van Baar, MJB, et al. The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial. Kidney Int 97 (2020), 202–212.
-
(2020)
Kidney Int
, vol.97
, pp. 202-212
-
-
van Bommel, E.J.M.1
Muskiet, M.H.A.2
van Baar, M.J.B.3
-
11
-
-
85074346599
-
Sodium glucose cotransporter-2 inhibition and cardiorenal protection: JACC review topic of the week
-
Cherney, DZ, Odutayo, A, Aronson, R, Ezekowitz, J, Parker, JD, Sodium glucose cotransporter-2 inhibition and cardiorenal protection: JACC review topic of the week. J Am Coll Cardiol 74 (2019), 2511–2524.
-
(2019)
J Am Coll Cardiol
, vol.74
, pp. 2511-2524
-
-
Cherney, D.Z.1
Odutayo, A.2
Aronson, R.3
Ezekowitz, J.4
Parker, J.D.5
-
12
-
-
85043593833
-
Dapagliflozin in focal segmental glomerulosclerosis: a combined human-rodent pilot study
-
Rajasekeran, H, Reich, HN, Hladunewich, MA, et al. Dapagliflozin in focal segmental glomerulosclerosis: a combined human-rodent pilot study. Am J Physiol Renal Physiol 314 (2018), F412–F422.
-
(2018)
Am J Physiol Renal Physiol
, vol.314
, pp. F412-F422
-
-
Rajasekeran, H.1
Reich, H.N.2
Hladunewich, M.A.3
-
13
-
-
85017527761
-
Sodium glucose transporter-2 inhibition has no renoprotective effects on non-diabetic chronic kidney disease
-
Ma, Q, Steiger, S, Anders, HJ, Sodium glucose transporter-2 inhibition has no renoprotective effects on non-diabetic chronic kidney disease. Physiol Rep, 5, 2017, e13228.
-
(2017)
Physiol Rep
, vol.5
-
-
Ma, Q.1
Steiger, S.2
Anders, H.J.3
-
14
-
-
84954104372
-
Sodium-glucose linked cotransporter-2 inhibition does not attenuate disease progression in the rat remnant kidney model of chronic kidney disease
-
Zhang, Y, Thai, K, Kepecs, DM, Gilbert, RE, Sodium-glucose linked cotransporter-2 inhibition does not attenuate disease progression in the rat remnant kidney model of chronic kidney disease. PLoS One, 11, 2016, e0144640.
-
(2016)
PLoS One
, vol.11
-
-
Zhang, Y.1
Thai, K.2
Kepecs, D.M.3
Gilbert, R.E.4
-
15
-
-
85051371074
-
A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice
-
Zhang, Y, Nakano, D, Guan, Y, et al. A sodium-glucose cotransporter 2 inhibitor attenuates renal capillary injury and fibrosis by a vascular endothelial growth factor-dependent pathway after renal injury in mice. Kidney Int 94 (2018), 524–535.
-
(2018)
Kidney Int
, vol.94
, pp. 524-535
-
-
Zhang, Y.1
Nakano, D.2
Guan, Y.3
-
16
-
-
65649142017
-
A new equation to estimate glomerular filtration rate
-
Levey, AS, Stevens, LA, Schmid, CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 150 (2009), 604–612.
-
(2009)
Ann Intern Med
, vol.150
, pp. 604-612
-
-
Levey, A.S.1
Stevens, L.A.2
Schmid, C.H.3
-
17
-
-
0015429594
-
A simple method for the determination of glomerular filtration rate
-
Bröchner-Mortensen, J, A simple method for the determination of glomerular filtration rate. Scand J Clin Lab Invest 30 (1972), 271–274.
-
(1972)
Scand J Clin Lab Invest
, vol.30
, pp. 271-274
-
-
Bröchner-Mortensen, J.1
-
18
-
-
33744839368
-
A formula to estimate the approximate surface area if height and weight be known
-
Du Bois, D, Du Bois, EF, A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 17 (1916), 863–871.
-
(1916)
Arch Intern Med
, vol.17
, pp. 863-871
-
-
Du Bois, D.1
Du Bois, E.F.2
-
19
-
-
85021254729
-
Effects of empagliflozin on the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and established cardiovascular disease: an exploratory analysis from the EMPA-REG OUTCOME randomised, placebo-controlled trial
-
Cherney, DZI, Zinman, B, Inzucchi, SE, et al. Effects of empagliflozin on the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and established cardiovascular disease: an exploratory analysis from the EMPA-REG OUTCOME randomised, placebo-controlled trial. Lancet Diabetes Endocrinol 5 (2017), 610–621.
-
(2017)
Lancet Diabetes Endocrinol
, vol.5
, pp. 610-621
-
-
Cherney, D.Z.I.1
Zinman, B.2
Inzucchi, S.E.3
-
20
-
-
85010952053
-
Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers
-
Heerspink, HJL, Johnsson, E, Gause-Nilsson, I, Cain, VA, Sjöström, CD, Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers. Diabetes Obes Metab 18 (2016), 590–597.
-
(2016)
Diabetes Obes Metab
, vol.18
, pp. 590-597
-
-
Heerspink, H.J.L.1
Johnsson, E.2
Gause-Nilsson, I.3
Cain, V.A.4
Sjöström, C.D.5
-
21
-
-
85019905074
-
The albuminuria-lowering response to dapagliflozin is variable and reproducible among individual patients
-
Petrykiv, SI, Laverman, GD, de Zeeuw, D, Heerspink, HJL, The albuminuria-lowering response to dapagliflozin is variable and reproducible among individual patients. Diabetes Obes Metab 19 (2017), 1363–1370.
-
(2017)
Diabetes Obes Metab
, vol.19
, pp. 1363-1370
-
-
Petrykiv, S.I.1
Laverman, G.D.2
de Zeeuw, D.3
Heerspink, H.J.L.4
-
22
-
-
85079082162
-
Rationale and protocol of the dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) randomized controlled trial
-
Heerspink, HJL, Stefansson, BV, Chertow, GM, et al. Rationale and protocol of the dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) randomized controlled trial. Nephrol Dial Transplant 35 (2020), 274–282.
-
(2020)
Nephrol Dial Transplant
, vol.35
, pp. 274-282
-
-
Heerspink, H.J.L.1
Stefansson, B.V.2
Chertow, G.M.3
-
23
-
-
85086569087
-
Farxiga phase III DAPA-CKD trial will be stopped early after overwhelming efficacy in patients with chronic kidney disease
-
(Accessed 17 April 2020)
-
AstraZeneca. Farxiga phase III DAPA-CKD trial will be stopped early after overwhelming efficacy in patients with chronic kidney disease. https://www.astrazeneca.com/media-centre/press-releases/2020/farxiga-phase-iii-dapa-ckd-trial-will-be-stopped-early-after-overwhelming-efficacy-in-patients-with-chronic-kidney-disease.html, March 30, 2020. (Accessed 17 April 2020)
-
(2020)
-
-
-
24
-
-
85044426288
-
SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism
-
Layton, AT, Vallon, V, SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism. Am J Physiol Renal Physiol 314 (2018), F969–F984.
-
(2018)
Am J Physiol Renal Physiol
, vol.314
, pp. F969-F984
-
-
Layton, A.T.1
Vallon, V.2
-
25
-
-
85064442920
-
Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation
-
Sayour, AA, Korkmaz-Icöz, S, Loganathan, S, et al. Acute canagliflozin treatment protects against in vivo myocardial ischemia-reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation. J Transl Med, 17, 2019, 127.
-
(2019)
J Transl Med
, vol.17
, pp. 127
-
-
Sayour, A.A.1
Korkmaz-Icöz, S.2
Loganathan, S.3
-
26
-
-
85075087714
-
Empagliflozin and dapagliflozin reduce ROS generation and restore NO bioavailability in tumor necrosis factor α-stimulated human coronary arterial endothelial cells
-
Uthman, L, Homayr, A, Juni, RP, et al. Empagliflozin and dapagliflozin reduce ROS generation and restore NO bioavailability in tumor necrosis factor α-stimulated human coronary arterial endothelial cells. Cell Physiol Biochem 53 (2019), 865–886.
-
(2019)
Cell Physiol Biochem
, vol.53
, pp. 865-886
-
-
Uthman, L.1
Homayr, A.2
Juni, R.P.3
-
27
-
-
84980320178
-
Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications
-
Heerspink, HJL, Perkins, BA, Fitchett, DH, Husain, M, Cherney, DZI, Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications. Circulation 134 (2016), 752–772.
-
(2016)
Circulation
, vol.134
, pp. 752-772
-
-
Heerspink, H.J.L.1
Perkins, B.A.2
Fitchett, D.H.3
Husain, M.4
Cherney, D.Z.I.5
-
28
-
-
85076595299
-
Mediators of the effects of canagliflozin on heart failure in patients with type 2 diabetes
-
Li, J, Woodward, M, Perkovic, V, et al. Mediators of the effects of canagliflozin on heart failure in patients with type 2 diabetes. JACC Heart Fail 8 (2020), 57–66.
-
(2020)
JACC Heart Fail
, vol.8
, pp. 57-66
-
-
Li, J.1
Woodward, M.2
Perkovic, V.3
-
29
-
-
85028413629
-
Pooled analysis of phase III trials indicate contrasting influences of renal function on blood pressure, body weight, and HbA1c reductions with empagliflozin
-
Cherney, DZI, Cooper, ME, Tikkanen, I, et al. Pooled analysis of phase III trials indicate contrasting influences of renal function on blood pressure, body weight, and HbA1c reductions with empagliflozin. Kidney Int 93 (2018), 231–244.
-
(2018)
Kidney Int
, vol.93
, pp. 231-244
-
-
Cherney, D.Z.I.1
Cooper, M.E.2
Tikkanen, I.3
-
30
-
-
85073118508
-
Dapagliflozin in patients with heart failure and reduced ejection fraction
-
McMurray, JJV, Solomon, SD, Inzucchi, SE, et al. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med 381 (2019), 1995–2008.
-
(2019)
N Engl J Med
, vol.381
, pp. 1995-2008
-
-
McMurray, J.J.V.1
Solomon, S.D.2
Inzucchi, S.E.3
|