Real-time tracking of self-reported symptoms to predict potential COVID-19

Nature Medicine

Volumn 26, Issue 7, 2020, Pages 1037-1040

  Menni, Cristina ^a   Valdes, Ana M ^a,b   Freidin, Maxim B ^a   Sudre, Carole H ^a   Nguyen, Long H ^c   Drew, David A ^c   Ganesh, Sajaysurya ^d   Varsavsky, Thomas ^a   Cardoso, M Jorge ^a   El Sayed Moustafa, Julia S ^a   Visconti, Alessia ^a   Hysi, Pirro ^a   Bowyer, Ruth C E ^a   Mangino, Massimo ^a,e   Falchi, Mario ^a   Wolf, Jonathan ^d   Ourselin, Sebastien ^a   Chan, Andrew T ^c   Steves, Claire J ^a   Spector, Tim D ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Zoe Global Limited   (United Kingdom)

^e BHF Centre for Regenerative Medicine and BHF Centre of Excellence and the Biomedical Research Centre at Guy s St Thomas NHS Foundation Trust and King s College London   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL PAIN; ADULT; ARTICLE; BODY MASS; CLINICAL FEATURE; CONTROLLED STUDY; CORONAVIRUS DISEASE 2019; COUGHING; DELIRIUM; DIARRHEA; DYSPNEA; FATIGUE; FEMALE; FEVER; HUMAN; LOSS OF APPETITE; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; THORAX PAIN; AGED; BETACORONAVIRUS; BIOLOGICAL MODEL; COMPUTER SYSTEM; CORONAVIRUS INFECTION; DISEASE NOTIFICATION; MIDDLE AGED; MOBILE APPLICATION; PANDEMIC; PATHOLOGY; PHYSIOLOGY; PROCEDURES; PRODROMAL SYMPTOM; PROGNOSIS; SELF REPORT; SEVERITY OF ILLNESS INDEX; SMARTPHONE; SMELLING DISORDER; TASTE DISORDER; UNITED KINGDOM; UNITED STATES; VIRUS PNEUMONIA;

ADULT; AGED; BETACORONAVIRUS; COMPUTER SYSTEMS; CORONAVIRUS INFECTIONS; COUGH; DISEASE NOTIFICATION; DYSPNEA; FATIGUE; FEMALE; HUMANS; MALE; MIDDLE AGED; MOBILE APPLICATIONS; MODELS, BIOLOGICAL; OLFACTION DISORDERS; PANDEMICS; PNEUMONIA, VIRAL; PRODROMAL SYMPTOMS; PROGNOSIS; SELF REPORT; SEVERITY OF ILLNESS INDEX; SMARTPHONE; TASTE DISORDERS; UNITED KINGDOM; UNITED STATES;

EID: 85084445397     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/s41591-020-0916-2     Document Type: Article

References (13)

1. Whittington, A. M. et al. Coronavirus: rolling out community testing for COVID-19 in the NHS. BMJ Opinion https://blogs.bmj.com/bmj/2020/02/17/coronavirus-rolling-out-community-testing-for-covid-19-in-the-nhs/ (2020).
2. Rossman, H. et al. A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys. Nat. Med. 10.1038/s41591-020-0857-9 (2020).
3. Gane, S. B., Kelly, C. & Hopkins, C. Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology https://doi.org/10.4193/Rhin20.114 (2020).
4. Iacobucci, G. Sixty seconds on… anosmia. Br. Med. J. 368, m1202 (2020). DOI: 10.1136/bmj.m1202
5. Brann, D. et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Preprint at bioRxiv https://www.biorxiv.org/content/10.1101/2020.03.25.009084v3 (2020).
6. Sungnak, W. et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat. Med. 10.1038/s41591-020-0868-6 (2020).
7. Hopkiins, C. & Kumar, N. Loss of Sense of Smell as Marker of COVID-19 Infection (ENT UK, 2020).
8. Eliezer, M. et al. Sudden and complete olfactory loss function as a possible symptom of COVID-19. JAMA Otolaryngol. Head Neck Surg. 10.1001/jamaoto.2020.0832 (2020).
9. Spinato, G. et al. Alterations in smell or taste in mildly symptomatic outpatients with SARS-CoV-2 infection. J. Am. Med. Assoc. 10.1001/jama.2020.6771 (2020).
10. Drew, D. et al. Rapid implementation of mobile technology for real-time epidemiology of COVID-19. Science https://science.sciencemag.org/content/early/2020/05/04/science.abc0473/tab-article-info (2020).
11. Roberts, M. Coronavirus: are loss of smell and taste key symptoms? BBC News (1 April 2020).
12. Oleszkiewicz, A., Kunkel, F., Larsson, M. & Hummel, T. Consequences of undetected olfactory loss for human chemosensory communication and well-being. Phil. Trans. R. Soc. Lond. B Biol. Sci. 375, 20190265 (2020). DOI: 10.1098/rstb.2019.0265
13. LeDell, E., Petersen, M. & van der Laan, M. Computationally efficient confidence intervals for cross-validated area under the ROC curve estimates. Electron J. Stat. 9, 1583–1607 (2015). DOI: 10.1214/15-EJS1035