Effects of nonnutritive sweeteners on body weight and BMI in diverse clinical contexts: Systematic review and meta-analysis

Obesity Reviews

Volumn 21, Issue 7, 2020, Pages

  Laviada Molina, Hugo ^a   Molina Segui, Fernanda ^a   Pérez Gaxiola, Giordano ^b   Cuello García, Carlos ^c   Arjona Villicaña, Ruy ^d   Espinosa Marrón, Alan ^a   Martinez Portilla, Raigam Jafet ^e  

^a Universidad Marista de Merida   (Mexico)

^b Servicio de Hematología Y Oncología Hospital Pediátrico de Sinaloa Dr Rigoberto Aguilar Pico   (Mexico)

^c MCMASTER UNIVERSITY   (Canada)

^d Infectious Diseases Research Unit Hospital Regional de Alta Especialidad de la Península de Yucatán   (Mexico)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

artificial sweeteners; body weight; obesity; systematic review

Indexed keywords

NONNUTRITIVE SWEETENER; PLACEBO; SUCROSE; WATER;

AGE; BODY MASS; BODY WEIGHT; CALORIC INTAKE; HUMAN; OBESITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEX DIFFERENCE; SYSTEMATIC REVIEW; DIET; DRUG EFFECT; META ANALYSIS; PATHOPHYSIOLOGY;

BODY MASS INDEX; BODY WEIGHT; DIET; HUMANS; NON-NUTRITIVE SWEETENERS; OBESITY;

EID: 85082802114     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/obr.13020     Document Type: Review

References (47)

1. World Health Organization. Obesity and overweight. 2018. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Published February 16, 2018. Accessed October 12, 2019.
2. Gardner C, Wylie-Rosett J, Gidding SS, et al. Nonnutritive sweeteners: current use and health perspectives—a scientific statement from the American Heart Association and the American Diabetes Association. Circulation. 2012;126(4):509-519. https://doi.org/10.1161/CIR.0b013e31825c42ee
3. Yang Q. Gain weight by “going diet?” artificial sweeteners and the neurobiology of sugar cravings. Yale J Biol Med. 2010;83(2):101-108.
4. Suez J, Shapiro H, Elinav E. Role of the microbiome in the normal and aberrant glycemic response. Clin Nutr Exp. 2016;6:59-73. https://doi.org/10.1016/j.yclnex.2016.01.001
5. Mattes RD, Popkin BM. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr. 2009;89(1):1-14. https://doi.org/10.3945/ajcn.2008.26792
6. Mattes RD. Low calorie sweeteners: science and controversy. Physiol Behav. 2016;164(Pt B):429-431. https://doi.org/10.1016/j.physbeh.2016.01.005
7. Rogers PJ, Hogenkamp PS, De Graaf C, et al. Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies. Int J Obes (Lond). 2016;40(3):381-394. https://doi.org/10.1038/ijo.2015.177
8. Campos V, Despland C, Brandejsky V, et al. Sugar- and artificially sweetened beverages and intrahepatic fat: a randomized controlled trial. Obesity. 2015;23(12):2335-2339. https://doi.org/10.1002/oby.21310
9. Peters JC, Beck J, Cardel M, et al. The effects of water and non-nutritive sweetened beverages on weight loss and weight maintenance: a randomized clinical trial. Obesity. 2016;24(2):297-304. https://doi.org/10.1002/oby.21327
10. Madjd A, Taylor MA, Delavari A, Malekzadeh R, Macdonald IA, Farshchi HR. Effects of replacing diet beverages with water on weight loss and weight maintenance: 18-month follow-up, randomized clinical trial. Int J Obes (Lond). 2018;42(4):835-840. https://doi.org/10.1038/ijo.2017.306
11. Higgins KA, Considine RV, Mattes RD. Aspartame consumption for 12 weeks does not affect glycemia, appetite, or body weight of healthy, lean adults in a randomized controlled trial. J Nutr. 2018;148(4):650-657. https://doi.org/10.1093/jn/nxy021
12. Higgins KA, Mattes RD. A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity. Am J Clin Nutr. 2019;109(5):1288-1301. https://doi.org/10.1093/ajcn/nqy381
13. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100. https://doi.org/10.1371/journal.pmed.1000100
14. Bennett JA. The Consolidated Standards of Reporting Trials (CONSORT): guidelines for reporting randomized trials. Nurs Res. 2005;54(2):128-132. https://doi.org/10.1097/00006199-200503000-00007
15. Ferreira AVM, Generoso SV, Teixeira AL. Do low-calorie drinks ‘cheat' the enteral-brain axis? Curr Opin Clin Nutr Metab Care. 2014;17(5):465-470. https://doi.org/10.1097/MCO.0000000000000082
16. st ed. Copenhagen; 2014.
17. Higgins J, Green S. The standardized mean difference. In: Higgins J, ed. Cochrane Handbook for Systematic Reviews of Interventions. 6th ed. West Sussex: Wiley-Blackwell; 2011.
18. 2 is not an absolute measure of heterogeneity. Res Synth Methods. 2017;8(1):5-18. https://doi.org/10.1002/jrsm.1230
19. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to Meta-Analysis. 1rst ed. Chichester: John Wiley & Sons; 2009.
20. Schwarzer G. meta: an R package for meta-analysis. R News. 2007;7:40-45.
21. Reid M, Hammersley R, Duffy M. Effects of sucrose drinks on macronutrient intake, body weight, and mood state in overweight women over 4 weeks. Appetite. 2010;55(1):130-136. https://doi.org/10.1016/j.appet.2010.05.001
22. Reid M, Hammersley R, Duffy M, Ballantyne C. Effects on obese women of the sugar sucrose added to the diet over 28 d: a quasi-randomised, single-blind, controlled trial. Br J Nutr. 2014;111(3):563-570. https://doi.org/10.1017/S0007114513002687
23. Tate DF, Turner-McGrievy G, Stevens J, et al. Replacing caloric beverages with water or diet beverages for weight loss in adults: results of a 6-month randomized controlled trial. Am Clin Nutr. 2011;95(3):555-563. https://doi.org/10.3945/ajcn.111.026278
24. Knopp RH, Brandt K, Arky RA. Effects of aspartame in young persons during weight reduction. J Toxicol Environ Health. 1976;2(2):417-428. https://doi.org/10.1080/15287397609529443
25. De Ruyter JC, Olthof MR, Seidell JC, Katan MB. A trial of sugar-free or sugar-sweetened beverages and body weight in children. N Engl J Med. 2012;367(15):1397-1406. https://doi.org/10.1056/NEJMoa1203034
26. Ebbeling CB, Feldman HA, Osganian SK, Chomitz VR, Ellenbogen SJ, Ludwig DS. Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents: a randomized, controlled pilot study. Pediatrics. 2006;117(3):673-680. https://doi.org/10.1542/peds.2005-0983
27. Ebbeling CB, Feldman HA, Chomitz VR, et al. A randomized trial of sugar-sweetened beverages and adolescent body weight. N Engl J Med. 2012;367(15):1407-1416. https://doi.org/10.1056/NEJMoa1203388
28. Frey GH. Use of aspartame by apparently healthy children and adolescents. J Toxicol Environ Health. 1976;2(2):401-415. https://doi.org/10.1080/15287397609529442
29. Kanders BS, Lavin PT, Kowalchuk MB, Greenberg I, Blackburn GL. An evaluation of the effect of aspartame on weight loss. Appetite. 1988;11(1):73-84.
30. Maersk M, Belza A, Stødkilde-Jørgensen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. 2012;95(2):283-289. https://doi.org/10.3945/ajcn.111.022533
31. Koyuncu BU, Balci MK. Metabolic effects of dissolved aspartame in the mouth before meals1 in prediabetic patients; a randomized controlled cross-over study. J Endocrinol Diabetes Obes. 2014;2(2):1032.
32. Blackburn GL, Kanders BS, Lavin PT, Keller SD, Whatley J. The effect of aspartame as part of a multidisciplinary weight-control program on short- and long-term control of body weight. Am J Clin Nutr. 1997;65(2):409-418. https://doi.org/10.1093/ajcn/65.2.409
33. Maki KC, Curry LL, Carakostas MC, et al. The hemodynamic effects of rebaudioside A in healthy adults with normal and low-normal blood pressure. Food Chem Toxicol. 2008;46:S40-S46. https://doi.org/10.1016/j.fct.2008.04.040
34. Raben A, Vasilaras T, Møller C, Astrup A. Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10 wk of supplementation in overweight subjects. Am J Clin Nutr. 2002;76(4):721-729. https://doi.org/10.1093/ajcn/76.4.721
35. Reid M, Hammersley R, Hill AJ, Skidmore P. Long-term dietary compensation for added sugar: effects of supplementary sucrose drinks over a 4-week period. Br J Nutr. 2007;97(1):193-203. https://doi.org/10.1017/S0007114507252705
36. Azad MB, Abou-Setta AM, Chauhan BF, et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. Cmaj. 2017;189(28):E929-E939. https://doi.org/10.1503/cmaj.161390
37. Toews I, Lohner S, de Gaudry DK, Sommer H, Meerpohl JJ. Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies. BMJ. 2019;364:k4718. https://doi.org/10.1136/bmj.k4718
38. Miller PE, Perez V. Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies. Am J Clin Nutr. 2014;100(3):765-777. https://doi.org/10.3945/ajcn.113.082826
39. Romo-Romo A, Aguilar-Salinas CA, Brito-Cordova GX, Diaz RAG, Valentin DV, Almeda-Valdes P. Effects of the non-nutritive sweeteners on glucose metabolism and appetite regulating hormones: systematic review of observational prospective studies and clinical trials. PLoS One. 2016;11(8):1-17. https://doi.org/10.1371/journal.pone.0161264
40. Johnson RK, Lichtenstein AH, Anderson CAM, et al. Low-calorie sweetened beverages and cardiometabolic health: a science advisory from the American Heart Association. Circulation. 2018;138(9):e126-e140. https://doi.org/10.1161/CIR.0000000000000569
41. Cummings P, Psaty BM. The association between cholesterol and death from injury. Ann Intern Med. 1994;120(10):848-855. https://doi.org/10.7326/0003-4819-120-10-199405150-00006
42. Pritchard KI. Should observational studies be a thing of the past? J Natl Cancer Inst. 2008;100(7):451-452. https://doi.org/10.1093/jnci/djn074
43. Maki KC, Slavin JL, Rains TM, Kris-Etherton PM. Limitations of observational evidence: implications for evidence-based dietary recommendations. Adv Nutr. 2014;5(1):7-15. https://doi.org/10.3945/an.113.004929
44. Sievenpiper JL, Khan TA, Ha V, Viguiliouk E, Auyeung R. The importance of study design in the assessment of nonnutritive sweeteners and cardiometabolic health. Can Med Assoc J. 2017;189(46):E1424-E1425. https://doi.org/10.1503/cmaj.733381
45. Koehler K, De Souza MJ, Williams NI. Less-than-expected weight loss in normal-weight women undergoing caloric restriction and exercise is accompanied by preservation of fat-free mass and metabolic adaptations. Eur J Clin Nutr. 2017;71(3):365-371. https://doi.org/10.1038/ejcn.2016.203
46. López-García R, Socolovsky S. General features, safety and regulation of non-caloric sweeteners. Arch Cardiol Mex. 2017;87:1-12.
47. Franz MJ, VanWormer JJ, Crain AL, et al. Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. J am Diet Assoc. 2007;107(10):1755-1767. https://doi.org/10.1016/j.jada.2007.07.017