Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

Emerging Microbes and Infections

Volumn 9, Issue 1, 2020, Pages 757-760

  Meng, Juan ^a,b   Xiao, Guohui ^a,b   Zhang, Juanjuan ^a   He, Xing ^a   Ou, Min ^a   Bi, Jing ^a   Yang, Rongqing ^a   Di, Wencheng ^a   Wang, Zhaoqin ^a   Li, Zigang ^b   Gao, Hong ^a   Liu, Lei ^a   Zhang, Guoliang ^a,b  

^a SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Shenzhen Bay Laboratory   (China)

Author keywords

angiotensin II type1 receptor blockers; angiotensin converting enzyme inhibitors; COVID 19; hypertension; Renin angiotensin system

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; INTERLEUKIN 6; LACTATE DEHYDROGENASE; CD3 ANTIGEN; IL6 PROTEIN, HUMAN;

ADULT; ANTIHYPERTENSIVE THERAPY; BLOOD; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL OUTCOME; COMPARATIVE STUDY; CORONAVIRUS DISEASE 2019; ELECTRONIC MEDICAL RECORD; FEMALE; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYPERTENSION; HYPERTENSIVE PATIENT; ISCHEMIC HEART DISEASE; LACTATE DEHYDROGENASE BLOOD LEVEL; LETTER; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RETROSPECTIVE STUDY; VIRUS LOAD; AGED; BETACORONAVIRUS; CHINA; COMPLICATION; CORONAVIRUS INFECTION; CYTOLOGY; MIDDLE AGED; PANDEMIC; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; TREATMENT OUTCOME; VIROLOGY; VIRUS PNEUMONIA;

AGED; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; BETACORONAVIRUS; C-REACTIVE PROTEIN; CD3 COMPLEX; CD8-POSITIVE T-LYMPHOCYTES; CHINA; CORONAVIRUS INFECTIONS; FEMALE; HUMANS; HYPERTENSION; INTERLEUKIN-6; MALE; MIDDLE AGED; PANDEMICS; PNEUMONIA, VIRAL; RENIN-ANGIOTENSIN SYSTEM; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; VIRAL LOAD;

EID: 85082791338     PISSN: None     EISSN: 22221751     Source Type: Journal    
DOI: 10.1080/22221751.2020.1746200     Document Type: Letter

References (12)

1. Wu Z, McGoogan JM., Characteristics of and important Lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a Report of 72 314 cases from the Chinese Center for disease control and Prevention. JAMA. 2020.
2. Wang Z, Chen Z, Zhang L, et al. Status of Hypertension in China: Results from the China Hypertension Survey, 2012-2015. Circulation: CIRCULATIONAHA.117.032380.
3. Hampl V, Herget J, Bíbová J, et al. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia. Physiol Res. 2015;64(1):25–38.
4. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020.
5. Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. Nat. Med. 2005;11(8):875–879. doi: 10.1038/nm1267
6. Moon JY., Recent Update of renin-angiotensin-aldosterone. Sys Pathogenesis Hypertens. 2013;11(2):41–45.
7. Yang P, Gu H, Zhao Z, et al. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 2015;4(1):7027. doi: 10.1038/srep07027
8. Liu Y, Yang Y, Zhang C, et al. Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury. Beijing: Science China Life sciences; 2020.
9. Hsu WT, Galm BP, Schrank G, et al. Effect of renin-angiotensin-aldosterone system inhibitors on short-Term mortality After sepsis: a population-based aohort study. Hypertension. 2020;75(2):483–491. doi: 10.1161/HYPERTENSIONAHA.119.13197
10. Wang X, Khaidakov M, Ding Z, et al. Cross-talk between inflammation and angiotensin II: studies based on direct transfection of cardiomyocytes with AT1R and AT2R cDNA. Exp Biol Med. 2012;237(12):1394–1401. doi: 10.1258/ebm.2012.012123
11. Ye R, Liu Z., ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway. Exp Mol Pathol. 2020;113:104350. doi: 10.1016/j.yexmp.2019.104350
12. Gage JR, Fonarow G, Hamilton M, et al. Beta Blocker and angiotensin-converting enzyme Inhibitor therapy Is associated with decreased Th1/Th2 cytokine ratios and inflammatory cytokine production in patients with chronic heart failure. Neuroimmunomodulation. 2004;11(3):173–180. doi: 10.1159/000076766