Fate of Pathologically Bound Oxygen Resulting from Inhalation of Labeled Ozone in Rats

Environmental Health Insights

Volumn 7, Issue , 2013, Pages

  Hatch, Gary E ^a   Slade, Ralph ^a   McKee, John ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

adducts; biomarkers; excretion; oxidative stress; ozone

Indexed keywords

EID: 85073226133     PISSN: None     EISSN: 11786302     Source Type: Journal    
DOI: 10.4137/EHI.S12673     Document Type: Article

References (26)

1. U.S. E. P. A. Air quality criteria for ozone and related photochemical oxidants: Integrated Science Assessment. Research Triangle Park, NC2013.
2. Devlin R.B., Duncan K.E., Jardim M., Schmitt M.T., Rappold A.G., Diaz-Sanchez D., Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects. Circulation. Jul 3, 2012; 126(1): 104–11.
3. Ito K., De Leon S.F., Lippmann M., Associations between ozone and daily mortality—Analysis and meta-analysis. Epidemiology. Jul 2005; 16(4): 446–57.
4. Bell M.L., McDermott A., Zeger S.L., Samet J.M., Dominici F., Ozone and short-term mortality in 95 US urban communities, 1987-2000. Jama-J Am Med Assoc. Nov 17, 2004; 292(19): 2372–8.
5. Frampton M.W., Pryor W.A., Cueto R., Cox C., Morrow P.E., Utell M.J., Ozone exposure increases aldehydes in epithelial lining fluid in human lung. Am J Respir Crit Care Med. Apr 1999; 159(4): 1134–7.
6. Mudway I.S., Kelly F.J., Ozone and the lung: a sensitive issue. Molecular Aspects of Medicine. 2000; 21(1-2): 1–48.
7. Liu L., Leech J.A., Urch R.B.. A comparison of biomarkers of ozone exposure in human plasma, nasal lavage, and sputum. Inhal Toxicol. 1999; 11(8): 657–74.
8. Foster W.M., Wills-Karp M., Tankersley C.G., Chen X., Paquette N.C., Bloodborne markers in humans during multiday exposure to ozone. J Appl Physiol. 1996; 81: 794–800.
9. Pryor W.A., How far does ozone penetrate into the pulmonary air tissue boundary before it reacts. Free Radical Bio Med. 1992; 12(1): 83–8.
10. Pryor W.A., Squadrito G.L., Friedman M., The cascade mechanism to explain ozone toxicity—the role of lipid ozonation products. Free Radical Bio Med. Dec 1995; 19(6): 935–41.
11. Chuang G.C., Yang Z., Westbrook D.G.. Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol-Lung C. Aug 2009; 297(2): L209–16.
12. Kodavanti U.P., Thomas R., Ledbetter A.D.. Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles. Environ Health Perspect. Mar 2011; 119(3): 312–8.
13. Kadiiska M.B., Hatch G.E., Nyska A.. Biomarkers of Oxidative Stress Study IV: Ozone exposure of rats and its effect on antioxidants in plasma and bronchoalveolar lavage fluid. Free Radical Biology & Medicine. 2011 Nov 1, 2011; 51(9): 1636–42. Epub Jul 2011.
14. Kadiiska M.B., Gladen B.C., Baird D.D.. Biomarkers of oxidative stress study: Are plasma antioxidants markers of CC1(4) poisoning? Free Radical Bio Med. Mar 2000; 28(6): 838–45.
15. Kadiiska M.B., Basu S., Brot N.. Biomarkers of oxidative stress study V: Ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine. Free Radical Bio Med. Aug 2013; 61: 408–15.
16. Hatch G.E., Slade R., Harris L.P.. Ozone dose and effect in humans and rats—a comparison using O-18 labeling and bronchoalveolar lavage. Am J Respir Crit Care Med. Sep 1994; 150(3): 676–83.
17. Hatch G.E., McKee J., Brown J.. Biomarkers of dose and effect of inhaled ozone in resting versus exercising human subjects: comparison with resting rats. Biomarker Insights. 2013; 8: 53–67.
18. 18O. Am J Physiol. 1999; 276: L332–40.
19. Hatch G.E., Slade R., Stead A.G., Graham J.A., Species comparison of acute inhalation toxicity of ozone and phosgene. J Toxicol Environ Health. 1986; 19(1): 43–53.
20. Bhalla D.K., Mannix R.C., Kleinman M.T., Crocker T.T., Relative permeability of nasal, tracheal, and bronchoalveolar mucosa to macromolecules in rats exposed to ozone. J Toxicol Environ Health. 1986; 17(2-3): 269–83.
21. Wright J.R., Clements J.A., Metabolism and turnover of lung surfactant. American Review of Respiratory Disease. Aug 1987; 136(2): 426–44.
22. Gordon C.J., Schladweiler M.C., Krantz T., King C., Kodavanti U.P., Cardiovascular and thermoregulatory responses of unrestrained rats exposed to filtered or unfiltered diesel exhaust. Inhal Toxicol. Apr 2012; 24(5): 296–309.
23. Santrock J., Hayes J.M., Adaptation of the unterzaucher procedure for determination of O-18 in organic-substances. Analytical Chemistry. Jan 1, 1987; 59(1): 119–27.
24. Stahl W.R., Scaling of respiratory variables in mammals. J Appl Physiol. 1967; 22: 453–60.
25. Wiester M.J., Tepper J.S., King M.E., Menache M.G., Costa D.L., Comparative-Study of Ozone (O3) Uptake in 3 Strains of Rats and in the Guinea-Pig. Toxicol Appl Pharm. Oct 1988; 96(1): 140–6.
26. Tepper J.S., Costa D.L., Lehmann J.R., Weber M.F., Hatch G.E., Unattenuated structural and biochemical-alterations in the rat lung during functional adaptation to ozone. American Review of Respiratory Disease. Aug 1989; 140(2): 493–501.