A further look at therapeutic interventions for suicide attempts and self-harm in adolescents: An updated systematic review of randomized controlled trials

Frontiers in Psychiatry

Volumn 9, Issue , 2018, Pages 1-16

  Iyengar, Udita ^a   Snowden, Natasha ^a   Asarnow, Joan R ^b   Moran, Paul ^c,d   Tranah, Troy ^a   Ougrin, Dennis ^a,e  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Adolescent; Depression; NSSI; RCT; Self harm; Suicidal ideation; Suicide

Indexed keywords

EID: 85070251967     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2018.00583     Document Type: Review

References (61)

1. Prevention NAAFS. (2014). Research Prioritization Task Force. A Prioritized Research Agenda for Suicide Prevention: An Action Plan to Save Lives. Rockville, MD: National Institute of Mental Health and Research Prioritization Task Force.
2. Patton GC, Coffey C, Sawyer SM, Viner RM, Haller DM, Bose K, et al. Global patterns of mortality in young people: A systematic analysis of population health data. Lancet (2009) 374:881–92. doi: 10.1016/S0140-6736(09) 60741-8
3. Butler AM, Malone K. Attempted suicide v. non-suicidal self-injury: Behaviour, syndrome or diagnosis? Br J Psychiatry (2013) 202:324–5. doi: 10.1192/bjp.bp.112.113506
4. American Psychiatric Association. (2013). Diagnostic and Statistical Manual ofMental Disorders, 5th edn. Arlington, VA: American Psychiatric Publishing.
5. Hawton K, Harriss L. Deliberate self-harm in young people: Characteristics and subsequent mortality in a 20-year cohort of patients presenting to hospital. J Clin Psychiatry (2007) 68:1574–83. doi: 10.4088/JCP.v68n1017
6. Asarnow JR, Porta G, Spirito A, Emslie G, Clarke G, Wagner KD, et al. Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: Findings from the TORDIA study. J Am Acad Child Adoles Psychiatry (2011) 50:772–81. doi: 10.1016/j.jaac.2011.04.003
7. Brent DA, McMakin DL, Kennard BD, Goldstein TR, Mayes TL, Douaihy AB. Protecting adolescents from self-harm: A critical review of intervention studies. J Am Acad Child Adoles Psychiatry (2013) 52:1260–71. doi: 10.1016/j.jaac.2013.09.009
8. Ougrin D, Boege I. Brief report: The Self Harm Questionnaire: A new tool designed to improve identification of self harm in adolescents. J Adoles. (2013) 36:221–5. doi: 10.1016/j.adolescence.2012.09.006
9. Moran P, Coffey C, Romaniuk H, Olsson C, Borschmann R, Carlin JB, et al. The natural history of self-harm from adolescence to young adulthood: A population-based cohort study. Lancet (2012) 379:236–43. doi: 10.1016/S0140-6736(11)61141-0
10. Rowe SL, French RS, Henderson C, Ougrin D, Slade M, Moran P. Helpseeking behaviour and adolescent self-harm: A systematic review. Aust N Zeal J Psychiatry (2014) 48:1083–95. doi: 10.1177/0004867414555718
11. Ougrin D, Tranah T, Stahl D, Moran P, Asarnow JR. Therapeutic interventions for suicide attempts and self-harm in adolescents: Systematic review and meta-analysis. J Am Acad Child Adoles Psychiatry (2015) 54:97–107.e102. doi: 10.1016/j.jaac.2014.10.009
12. Shaffer D, Gould MS, Fisher P, Trautman P, Moreau D, Kleinman M, et al. Psychiatric diagnosis in child and adolescent suicide. Arch Gener Psychiatry (1996) 53:339–48. doi: 10.1001/archpsyc.1996.01830040075012
13. Gould MS, King R, Greenwald S, Fisher P, Schwab-Stone M, Kramer R, et al. Psychopathology associated with suicidal ideation and attempts among children and adolescents. J Am Acad Child Adoles Psychiatry (1998) 37:915–23. doi: 10.1097/00004583-199809000-00011
14. National Confidential Inquiry into Suicide and Homicide by People with Mental Illness. (2017). Suicide by Children and Young People. Manchester: University of Manchester, 2017.
15. Lundh L-G, Wångby-Lundh M, Paaske M, Ingesson S, Bjärehed J. Depressive symptoms and deliberate self-harm in a community sample of adolescents: A prospective study. Depress Res Treat. (2011) 2011:935871. doi: 10.1155/2011/935871
16. Singhal A, Ross J, Seminog O, Hawton K, Goldacre MJ. Risk of self-harm and suicide in people with specific psychiatric and physical disorders: Comparisons between disorders using English national record linkage. J R Soc Med. (2014) 107:194–204. doi: 10.1177/0141076814522033
17. Yang F-Y, Lai CY, Yen C-F, Hsu Y-Y, Zauszniewski JA. The depressive symptoms, resourcefulness, and self-harm behaviors of adolescents. J Nurs Res. (2017) 25:41–9. doi: 10.1097/jnr.0000000000000127
18. Zubrick SR, Hafekost J, Johnson SE, Sawyer MG, Patton G, Lawrence D. The continuity and duration of depression and its relationship to non-suicidal selfharm and suicidal ideation and behavior in adolescents 12–17. J Affect Disord. (2017) 220:49–56. doi: 10.1016/j.jad.2017.05.050
19. Brent DA, Greenhill LL, Compton S, Emslie G, Wells K, Walkup JT, et al. The Treatment of Adolescent Suicide Attempters study (TASA): Predictors of suicidal events in an open treatment trial. J Am Acad Child Adoles Psychiatry (2009) 48:987–96. doi: 10.1097/CHI.0b013e3181b5dbe4
20. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials (1996) 17:1–12. doi: 10.1016/0197-2456(95)00134-4
21. Spirito A, Boergers J, Donaldson D, Bishop D, Lewander W. An intervention trial to improve adherence to community treatment by adolescents after a suicide attempt. J Am Acad Child Adolesc Psychiatry (2002) 41:435–42. doi: 10.1097/00004583-200204000-00016
22. Hazell PL, Martin G, McGill K, Kay T, Wood A, Trainor G, et al. Group therapy for repeated deliberate self-harm in adolescents: Failure of replication of a randomized trial. J Am Acad Child Adolesc Psychiatry (2009) 48:662–70. doi: 10.1097/CHI.0b013e3181a0acec
23. Green JM, Wood AJ, Kerfoot MJ, Trainor G, Roberts C, Rothwell J, et al. Group therapy for adolescents with repeated self harm: Randomised controlled trial with economic evaluation. BMJ (2011) 2011:342. doi: 10.1136/bmj.d682
24. Wood A, Trainor G, Rothwell J, Moore A, Harrington R. Randomized trial of group therapy for repeated deliberate self-harm in adolescents. J Am Acad Child Adolesc Psychiatry (2001) 40:1246–53. doi: 10.1097/00004583-200111000-00003
25. Schuppert HM, Timmerman ME, Bloo J, Van Gemert TG, Wiersema HM, Minderaa RB, et al. Emotion regulation training for adolescents with borderline personality disorder traits: A randomized controlled trial. J Am Acad Child Adolesc Psychiatry (2012) 51:1314–1323.e1312. doi: 10.1016/j.jaac.2012.09.002
26. Schuppert HM, Giesen-Bloo J, Van Gemert TG, Wiersema HM, Minderaa RB, Emmelkamp PM, et al. Effectiveness of an emotion regulation group training for adolescents—a randomized controlled pilot study. Clin Psychol Psychother. (2009) 16:467–78. doi: 10.1002/cpp.637
27. Alavi A, Sharifi B, Ghanizadeh A, Dehbozorgi G. Effectiveness of cognitivebehavioral therapy in decreasing suicidal ideation and hopelessness of the adolescents with previous suicidal attempts. Iran J Pediatrics (2013) 23:467–72. doi: 10.1016/j.neurenf.2012.04.266
28. Esposito-Smythers C, Spirito A, Kahler CW, Hunt J, Monti P. Treatment of co-occurring substance abuse and suicidality among adolescents: A randomized trial. J Consult Clin Psychol. (2011) 79:728–39. doi: 10.1037/a0026074
29. Mehlum L, Tormoen AJ, Ramberg M, Haga E, Diep LM, Laberg S, et al. Dialectical behavior therapy for adolescents with repeated suicidal and selfharming behavior: A randomized trial. J Am Acad Child Adolesc Psychiatry (2014) 53:1082–91. doi: 10.1016/j.jaac.2014.07.003
30. Donaldson D, Spirito A, Esposito-Smythers C. Treatment for adolescents following a suicide attempt: Results of a pilot trial. J Am Acad Child Adolesc Psychiatry (2005) 44:113–20. doi: 10.1097/00004583-200502000-00003
31. Asarnow JR, Hughes JL, Babeva KN, Sugar CA. Cognitive-behavioral family treatment for suicide attempt prevention: A randomized controlled trial. J Am Acad Child Adolesc Psychiatry (2017) 56:506–14. doi: 10.1016/j.jaac.2017.03.015
32. Rossouw TI, Fonagy P. Mentalization-based treatment for self-harm in adolescents: A randomized controlled trial. J AmAcad Child Adolesc Psychiatry (2012) 51:1304–1313.e1303. doi: 10.1016/j.jaac.2012.09.018
33. Chanen AM, Jackson HJ, McCutcheon LK, Jovev M, Dudgeon P, Yuen HP, et al. Early intervention for adolescents with borderline personality disorder using cognitive analytic therapy: Randomised controlled trial. Br J Psychiatry (2008) 193:477–84. doi: 10.1192/bjp.bp.107.048934
34. Ougrin D, Boege I, Stahl D, Banarsee R, Taylor E. Randomised controlled trial of therapeutic assessment versus usual assessment in adolescents with self-harm: 2-year follow-up. Arch Dis Child. (2013) 98:772–6. doi: 10.1136/archdischild-2012-303200
35. Cotgrove A, Zirinsky L, Black D, Weston D. Secondary prevention of attempted suicide in adolescence. J Adoles. (1995) 18:569. doi: 10.1006/jado.1995.1039
36. Harrington R, Kerfoot M, Dyer E, McNiven F, Gill J, Harrington V, et al. Randomized trial of a home-based family intervention for children who have deliberately poisoned themselves. J Am Acad Child Adolesc Psychiatry (1998) 37:512–8.
37. Wharff EA, Ginnis KB, Ross AM, White EM, White MT, Forbes PW. Family- Based Crisis Intervention With Suicidal Adolescents: A Randomized Clinical Trial. Pediatr Emerg Care (2017). doi: 10.1097/PEC.0000000000001076. [Epub ahead of print].
38. Diamond GS, Wintersteen MB, Brown GK, Diamond GM, Gallop R, Shelef K, et al. Attachment-based family therapy for adolescents with suicidal ideation: A randomized controlled trial. J Am Acad Child Adoles Psychiatry (2010) 49:122–31. doi: 10.1016/j.jaac.2009.11.002
39. King CA, Kramer A, Preuss L, Kerr DC, Weisse L, Venkataraman S. Youth-nominated support team for suicidal adolescents (Version 1): A randomized controlled trial. J Consult Clin Psychol. (2006) 74:199–206. doi: 10.1037/0022-006X.74.1.199
40. King CA, Klaus N, Kramer A, Venkataraman S, Quinlan P, Gillespie B. The youth-nominated support team–version ii for suicidal adolescents: A randomized controlled intervention trial. J Consult Clin Psychol. (2009) 77:880. doi: 10.1037/a0016552
41. Pineda J, Dadds MR. Family intervention for adolescents with suicidal behavior: A randomized controlled trial and mediation analysis. J Am Acad Child Adoles Psychiatry (2013) 52:851–62. doi: 10.1016/j.jaac.2013.05.015
42. Mehlum L, Ramberg M, Tørmoen AJ, Haga E, Diep LM, Stanley BH, et al. Dialectical behavior therapy compared with enhanced usual care for adolescents with repeated suicidal and self-harming behavior: Outcomes over a one-year follow-up. J Am Acad Child Adoles Psychiatry (2016) 55:295–300. doi: 10.1016/j.jaac.2016.01.005
43. Tørmoen A, Grøholt B, Haga E, Brager-Larsen A, Miller A, Walby F, et al. Feasibility of dialectical behavior therapy with suicidal and self-harming adolescents with multi-problems: Training, adherence, and retention. Arch Suic Res. (2014) 18:432–44. doi: 10.1080/13811118.2013. 826156
44. Stanley B, Brown G, Brent DA, Wells K, Poling K, Curry J, et al. Cognitivebehavioral therapy for suicide prevention (CBT-SP): Treatment model, feasibility, and acceptability. J Am Acad Child Adoles Psychiatry (2009) 48:1005–13. doi: 10.1097/CHI.0b013e3181b5dbfe
45. Vitiello B, Brent DA, Greenhill LL, Emslie G, Wells K, Walkup JT, et al. Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study. J Am Acad Child Adoles Psychiatry (2009) 48:997–1004. doi: 10.1097/CHI.0b013e3181b5db66
46. Wharff EA, Ginnis KM, Ross AM. Family-based crisis intervention with suicidal adolescents in the emergency room: A pilot study. Soc Work (2012) 57:133–43. doi: 10.1093/sw/sws017
47. Wilkinson P, Kelvin R, Roberts C, Dubicka B, Goodyer I. Clinical and psychosocial predictors of suicide attempts and nonsuicidal self-injury in the Adolescent Depression Antidepressants and Psychotherapy Trial (ADAPT). Am J Psychiatry (2011) 168:495–501. doi: 10.1176/appi.ajp.2010.10050718
48. National Center for Clinical Excellence. (2011). Self-Harm in Over 8s: Long- Term Management. (Clinical Guideline CGI 33). Available online at: Https:// www.nice.org.uk/guidance/cg133
49. Mohr DC, Ho J, Duffecy J, Baron KG, Lehman KA, Jin L, et al. Perceived barriers to psychological treatments and their relationship to depression. J Clin Psychol (2010) 66:394–409. doi: 10.1002/jclp.20659
50. Sturm R, Sherbourne CD. Are barriers to mental health and substance abuse care still rising? J Behav Health Serv Res. (2001) 28:81. doi: 10.1007/BF02287236
51. Cottrell DJ, Wright-Hughes A, Collinson M, Boston P, Eisler I, Fortune S, et al. Effectiveness of systemic family therapy versus treatment as usual for young people after self-harm: A pragmatic, phase 3, multicentre, randomised controlled trial. Lancet Psychiatry (2018) 5:203–16. doi: 10.1016/S2215-0366(18)30058-0
52. McCauley E, Berk MS, Asarnow JR, Adrian M, Cohen J, Korslund K, et al. Efficacy of dialectical behavior therapy for adolescents at high risk for suicide: A randomized clinical trial. JAMA Psychiatry (2018) 75:777–85. doi: 10.1001/jamapsychiatry.2018.1109
53. Ougrin D, Corrigall R, Poole J, Zundel T, Sarhane M, Slater V, et al. Comparison of effectiveness and cost-effectiveness of an intensive community supported discharge service versus treatment as usual for adolescents with psychiatric emergencies: A randomised controlled trial. Lancet Psychiatry (2018) 5:477–85. doi: 10.1016/S2215-0366(18)30129-9
54. Rees CS, Hasking P, Breen LJ, Lipp OV, Mamotte C. Group mindfulness based cognitive therapy vs. group support for self-injury among young people: Study protocol for a randomised controlled trial. BMC Psychiatry (2015) 15:154. doi: 10.1186/s12888-015-0527-5
55. Van Spijker BA, Calear AL, Batterham PJ, Mackinnon AJ, Gosling JA, Kerkhof AJ, et al. Reducing suicidal thoughts in the Australian general population through web-based self-help: Study protocol for a randomized controlled trial. Trials (2015) 16:62. doi: 10.1186/s13063-015-0589-1
56. Wright-Hughes A, Graham E, Farrin A, Collinson M, Boston P, Eisler I, et al. Self-Harm Intervention: Family Therapy (SHIFT), a study protocol for a randomised controlled trial of family therapy versus treatment as usual for young people seen after a second or subsequent episode of self-harm. Trials (2015) 16:501. doi: 10.1186/s13063-015- 1007-4
57. Haddock G, Davies L, Evans E, Emsley R, Gooding P, Heaney L, et al. Investigating the feasibility and acceptability of a cognitive behavioural suicide prevention therapy for people in acute psychiatric wards (the ‘INSITE’trial): Study protocol for a randomised controlled trial. Trials (2016) 17:79. doi: 10.1186/s13063-016-1192-9
58. Pepping CA, Lyons A, McNair R, Kirby JN, Petrocchi N, Gilbert P. A tailored compassion-focused therapy program for sexual minority young adults with depressive symotomatology: Study protocol for a randomized controlled trial. BMC Psychol. (2017) 5:5. doi: 10.1186/s40359-017- 0175-2
59. Asarnow JR, and Clarke G. (2017). Randomized Controlled Trial of Stepped Care for Suicide Prevention in Adolescents and Young Adults. Available online at: Https://clinicaltrials.gov: NIMH
60. Boudreaux E, and Kiefe C. (2017). A System of Safety: Preventing Suicided Through Healthcare System Transformation. Available online at: Https:// clinicaltrials.gov
61. Kemp K. (2017). Implementing a Brief Suicide Intervention for High Risk Youth With Front-Line Juvenile Justice Staff. Available online at: Https://clinicaltrials. gov