Looking to the future of organs-on-chips: Interview with Professor John Wikswo

Future Science OA

Volumn 3, Issue 2, 2017, Pages

  Wikswo, John P ^a  

^a VANDERBILT UNIVERSITY   (United States)

Author keywords

Bioengineering; Body on a chip; Drug development; Microfluidics; Organ on a chip; Systems biology; Toxicology

Indexed keywords

SEROTONIN;

ASTRONOMY; BIOCHIP; BIOMEDICAL ENGINEERING; BIOPHYSICS; BLOOD BRAIN BARRIER; CELL CULTURE TECHNIQUE; CELL DIFFERENTIATION; ENDOMETRIOSIS; HEART PAPILLARY MUSCLE; HOMEOSTASIS; HUMAN; INDUCED PLURIPOTENT STEM CELL; INTERDISCIPLINARY RESEARCH; INTERVIEW; LAB ON A CHIP; MAGNETIC FIELD; METABOLIC ACTIVITY ASSAY; METABOLOMICS; MICROFLUIDICS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; ORGANS ON CHIP; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SYSTEMS BIOLOGY; TRANSCRIPTOMICS;

EID: 85069008367     PISSN: None     EISSN: 20565623     Source Type: Journal    
DOI: 10.4155/fsoa-2016-0085     Document Type: Review

References (9)

1. Brown JA, Codreanu SG, Shi M, et al. Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit. J. Neuroinflammation 13, 306 (2016)
2. Sidorov VY, Samson PC, Sidorova TN, et al. I-Wire Heart-on-a-Chip I: Three dimensional cardiac tissue constructs for physiology and pharmacology. Acta Biomater. (2016) (In Press).
3. Schroer AK, Shotwell MS, Sidorov VY, et al. I-Wire Heart-on-a-Chip II: Biomechanical analysis of contractile three-dimensional cardiac tissue constructs. Acta Biomater. (2016) (In Press).
4. Wikswo JP. The relevance and potential roles of microphysiological systems in biology and medicine. Exp. Biol. Med. 239, 1061-1072 (2014).
5. Wikswo JP, Porter AP, Biology coming full circle: joining the whole and the parts. Exp. Biol. Med. 240, 3-7 (2015).
6. Brown JA, Sherrod SD, Goodwin CR, et al. Metabolic consequences of Interleukin-6 challenge in developing neurons and astroglia. J. Neuroinflammation 11, 183 (2014).
7. Zhang R, Lahens NF, Ballance HI, Hughes ME, Hogenesch JB. A circadian gene expression atlas in mammals: implications for biology and medicine. Proc. Natl Acad. Sci. USA 111(45), 16219-16224 (2014).
8. TEDx talk. http://tedxtalks.ted.com/video
9. Sutherland JJ, Jolly RA, Goldstein KM, Stevens JL. Assessing concordance of drug-induced transcriptional response in rodent liver and cultured hepatocytes. PLoS Comput. Biol. 12(3), e1004847 (2016).