Antimicrobial resistance or delayed appropriate therapy - Does one influence outcomes more than the other among patients with serious infections due to carbapenem-resistant versus carbapenem-susceptible enterobacteriaceae?

Open Forum Infectious Diseases

Volumn 6, Issue 6, 2019, Pages

  Lodise, Thomas P ^a   Berger, Ariel ^b   Altincatal, Arman ^b   Wang, Rosa ^b   Bhagnani, Tarun ^b   Gillard, Patrick ^c   Bonine, Nicole G ^c  

^a ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b EVIDERA   (United States)

^c ALLERGAN PLC   (United States)

Author keywords

Antibacterial drug resistance; Antibiotic resistance; Carbapenems; Cost of illness; Enterobacteriaceae

Indexed keywords

ABDOMINAL INFECTION; ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; CARBAPENEM-RESISTANT ENTEROBACTERIACEAE; COST OF ILLNESS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTION; FEMALE; HOSPITAL ACQUIRED PNEUMONIA; HOSPITAL MORTALITY; HOSPITALIZATION; HUMAN; ICD-9; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PARENTERAL NUTRITION; PRIORITY JOURNAL; SYNERGISTIC EFFECT; THERAPY DELAY; TREATMENT DURATION; TREATMENT OUTCOME; URINARY TRACT INFECTION;

EID: 85068513124     PISSN: None     EISSN: 23288957     Source Type: Journal    
DOI: 10.1093/ofid/ofz194     Document Type: Article

References (28)

1. Solomkin JS, Mazuski JE, Bradley JS, et al. Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America. Clin Infect Dis 2010; 50: 133-64.
2. Nicolle LE, Bradley S, Colgan R, et al.; Infectious Diseases Society of America; American Society of Nephrology; American Geriatric Society. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis 2005; 40: 643-54.
3. Friedman ND, Kaye KS, Stout JE, et al. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of communityacquired infections. Ann Intern Med 2002; 137: 791-7.
4. American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005; 171: 388-416.
5. Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. http://www. cdc. gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508. pdf. Published April 23, 2013. Accessed April 26, 2019.
6. Falagas ME, Tansarli GS, Karageorgopoulos DE, Vardakas KZ. Deaths attributable to carbapenem-resistant Enterobacteriaceae infections. Emerg Infect Dis 2014; 20: 1170-5.
7. Bogan C, Kaye KS, Chopra T, et al. Outcomes of carbapenem-resistant Enterobacteriaceae isolation: matched analysis. Am J Infect Control 2014; 42: 612-20.
8. Zilberberg MD, Nathanson BH, Sulham K, et al. Carbapenem resistance, inappropriate empiric treatment and outcomes among patients hospitalized with Enterobacteriaceae urinary tract infection, pneumonia and sepsis. BMC Infect Dis 2017; 17: 279.
9. Davey PG, Marwick C. Appropriate vs. inappropriate antimicrobial therapy. Clin Microbiol Infect 2008; 14 (Suppl 3): 15-21.
10. Jerardi KE, Auger KA, Shah SS, et al. Discordant antibiotic therapy and length of stay in children hospitalized for urinary tract infection. J Hosp Med 2012; 7: 622-7.
11. Lodise TP Jr, Patel N, Kwa A, et al. Predictors of 30-day mortality among patients with Pseudomonas aeruginosa bloodstream infections: impact of delayed appropriate antibiotic selection. Antimicrob Agents Chemother 2007; 51: 3510-5.
12. Snydman DR. Empiric antibiotic selection strategies for healthcare-associated pneumonia, intra-abdominal infections, and catheter-associated bacteremia. J Hosp Med 2012; 7 (Suppl 1): S2-12.
13. Sturkenboom MC, Goettsch WG, Picelli G, et al. Inappropriate initial treatment of secondary intra-abdominal infections leads to increased risk of clinical failure and costs. Br J Clin Pharmacol 2005; 60: 438-43.
14. Tellado JM, Sen SS, Caloto MT, et al. Consequences of inappropriate initial empiric parenteral antibiotic therapy among patients with community-acquired intra-abdominal infections in Spain. Scand J Infect Dis 2007; 39: 947-55.
15. Premier. Premier Research Database. https://www. premierinc. com/transforminghealthcare/healthcare-performance-improvement/premier-applied-sciences/. Accessed May 9, 2018.
16. Centers for Disease Control and Prevention. Facility guidance for control of carbapenem-resistant Enterobacteriaceae (CRE). 2012-CRE toolkit. http: www. cdc. gov/hai/organisms/cre/cre-toolkit/background. html. Accessed October 21, 2014.
17. Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clin Proc 2011; 86: 156-67.
18. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008; 36: 309-32.
19. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika 1983; 70: 41-55.
20. Austin PC. An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivariate Behav Res 2011; 46: 399-424.
21. Neuner EA, Yeh JY, Hall GS, et al. Treatment and outcomes in carbapenemresistant Klebsiella pneumoniae bloodstream infections. Diagn Microbiol Infect Dis 2011; 69: 357-62.
22. van Duin D, Kaye KS, Neuner EA, Bonomo RA. Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes. Diagn Microbiol Infect Dis 2013; 75: 115-20.
23. Al-Hasan MN, Lahr BD, Eckel-Passow JE, Baddour LM. Predictive scoring model of mortality in Gram-negative bloodstream infection. Clin Microbiol Infect 2013; 19: 948-54.
24. Rhee JY, Kwon KT, Ki HK, et al. Scoring systems for prediction of mortality in patients with intensive care unit-acquired sepsis: a comparison of the Pitt bacteremia score and the Acute Physiology and Chronic Health Evaluation II scoring systems. Shock 2009; 31: 146-50.
25. Roth JA, Tschudin-Sutter S, Dangel M, et al. Value of the Pitt Bacteraemia Score to predict short-term mortality in Staphylococcus aureus bloodstream infection: a validation study. Swiss Med Wkly 2017; 147: w14482.
26. Waters M, Nightingale P, Edwards JD. A critical study of the APACHE II scoring system using earlier data collection. Arch Emerg Med 1990; 7: 16-20.
27. Centers for Disease Control and Prevention. Facility guidance for control of carbapenem-resistant Enterobacteriaceae (CRE)-November 2015 update CRE toolkit. Available at: https://www. cdc. gov/hai/organisms/cre/cre-toolkit/index. html. Accessed April 19, 2018.
28. Bell DM. Promoting appropriate antimicrobial drug use: perspective from the Centers for Disease Control and Prevention. Clin Infect Dis 2001; 33 (Suppl 3): S245-50.