Elevated activated partial thromboplastin time-based clot waveform analysis markers have strong positive association with acute venous thromboembolism

Biochemia Medica

Volumn 29, Issue 2, 2019, Pages 385-393

  Tan, Chuen Wen ^a   Cheen, McVin Hua Heng ^a   Wong, Wan Hui ^a   Wu, Ian Qianhuang ^a   Chua, Brian Lee Wei ^a   Ahamedulla, Sahul Hameed ^a   Lee, Lai Heng ^a   Ng, Heng Joo ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Activated partial thromboplastin time; Blood coagulation; Thrombophilia; Thrombosis; Venous thromboembolism

Indexed keywords

BIOLOGICAL MARKER; ANTICOAGULANT AGENT;

ACTIVATED PARTIAL THROMBOPLASTIN TIME; ADULT; AGED; ANTICOAGULATION; ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; CLINICAL ARTICLE; CLINICAL FEATURE; CLOT WAVEFORM ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSESSMENT; DISEASE ASSOCIATION; ETHNICITY; FEMALE; HEMATOCRIT; HEMOSTATIC TECHNIQUE; HUMAN; MALE; OUTCOME ASSESSMENT; PREDICTIVE VALUE; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; THROMBOSIS; VENOUS THROMBOEMBOLISM; WAVEFORM; ACUTE DISEASE; BLOOD; BLOOD CLOTTING TEST; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; VERY ELDERLY; YOUNG ADULT;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; BLOOD COAGULATION TESTS; COMPUTED TOMOGRAPHY ANGIOGRAPHY; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; RETROSPECTIVE STUDIES; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 85068491277     PISSN: 13300962     EISSN: None     Source Type: Journal    
DOI: 10.11613/BM.2019.020710     Document Type: Article

References (28)

1. van Hylckama Vlieg A, van der Linden IK, Bertina RM, Rosendaal FR. High levels of factor IX increase the risk of venous thrombosis. Blood. 2000;95:3678-82.
2. Tsai AW, Cushman M, Rosamond WD, Heckbert SR, Tracy RP, Aleksic N, et al. Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE). Am J Med. 2002;113:636–42. https://doi.org/10.1016/S0002-9343(02)01345-1
3. van Hylckama Vlieg A, Rosendaal FR. High levels of fibrino-gen are associated with the risk of deep venous thrombosis mainly in the elderly. J Thromb Haemost. 2003;1:2677–8. https://doi.org/10.1111/j.1538-7836.2003.0543b.x
4. Tripodi A, Chantarangkul V, Martinelli I, Bucciarelli P, Mannucci PM. A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. Blood. 2004;104:3631-4. https://doi.org/10.1182/blood-2004-03-1042
5. Korte W, Clarke S, Lefkowitz JB. Short Activated Partial Thromboplastin Times Are Related to Increased Thrombin Generation and an Increased Risk for Thromboembolism. Am J Clin Pathol. 2000;113:123–7. https://doi.org/10.1309/G98J-ANA9-RMNC-XLYU
6. Hron G, Eichinger S, Weltermann A, Quehenberger P, Halb-mayer WM, Kyrle PA. Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time. J Thromb Haemost. 2006;4:752–6. https://doi.org/10.1111/j.1538-7836.2006.01868.x
7. Legnani C, Mattarozzi S, Cini M, Cosmi B, Favaretto E, Palareti G. Abnormally short activated partial thromboplastin time values are associated with increased risk of recurrence of venous thromboembolism after oral anticoagulation withdrawal. Br J Haematol. 2006;134:227–32. https://doi. org/10.1111/j.1365-2141.2006.06130.x
8. Tripodi A, Martinelli I, Chantarangkul V, Battaglioli T, Cle-rici M, Mannucci PM. The endogenous thrombin potential and the risk of venous thromboembolism. Thromb Res. 2007;121:353–9. https://doi.org/10.1016/j.thro-mres.2007.04.012
9. Tripodi A, Legnani C, Chantarangkul V, Cosmi B, Palareti G, Mannucci PM. High thrombin generation measured in the presence of thrombomodulin is associated with an increased risk of recurrent venous thromboembolism. J Thromb Haemost. 2008;6:1327–33. https://doi.org/10.1111/j.1538-7836.2008.03018.x
10. Dargaud Y, Trzeciak MC, Bordet JC, Ninet J, Negrier C. Use of calibrated automated thrombinography +/-thrombomodulin to recognise the prothrombotic phenotype. Thromb Haemost. 2006;96:562–7. https://doi.org/10.1160/TH06-03-0179
11. Lipets EN, Ataullakhanov FI. Global assays of hemostasis in the diagnostics of hypercoagulation and evaluation of thrombosis risk. Thromb J. 2015;13:4. https://doi. org/10.1186/s12959-015-0038-0
12. van Hylckama Vlieg A, Christiansen SC, Luddington R, Cannegieter SC, Rosendaal FR, Baglin TP. Elevated endogenous thrombin potential is associated with an increased risk of a first deep venous thrombosis but not with the risk of recurrence. Br J Haematol. 2007;138:769–74. https://doi. org/10.1111/j.1365-2141.2007.06738.x
13. Toh CH, Samis J, Downey C, Walker J, Becker L, Brufatto N, et al. Biphasic transmittance waveform in the APTT coagulation assay is due to the formation of a Ca++-dependent complex of C-reactive protein with very-low-density lipoprotein and is a novel marker of impending disseminated intravascular coagulation. Blood. 2002;100:2522–9. https://doi. org/10.1182/blood.V100.7.2522
14. Matsumoto T, Shima M, Takeyama M, Yoshida K, Tanaka I, Sakurai Y, et al. The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assay. J Thromb Haemost. 2006;4:377–84. https://doi.org/10.1111/j.1538-7836.2006.01730.x
15. Haku J, Nogami K, Matsumoto T, Ogiwara K, Shima M. Optimal monitoring of bypass therapy in hemophilia A pati- ents with inhibitors by the use of clot waveform analysis. J Thromb Haemost. 2014;12:355–62. https://doi.org/10.1111/jth.12488
16. Siegemund T, Scholz U, Schobess R, Siegemund A. Clot waveform analysis in patients with haemophilia A. Hamosta-seologie. 2014;34:S48–52. https://doi.org/10.5482/HAMO-14-02-0016
17. Ruberto MF, Marongiu F, Mandas A, Mameli A, Porru M, Ci-anchetti E, et al. The venous thromboembolic risk and the clot wave analysis: a useful relationship? Clin Chem Lab Med. 2018;56:448–53. https://doi.org/10.1515/cclm-2017-0678
18. Nogami K, Matsumoto T, Tabuchi Y, Soeda T, Arai N, Ki-tazawa T, et al. Modified clot waveform analysis to measure plasma coagulation potential in the presence of the anti-factor IXa/factor X bispecific antibody emicizu-mab. J Thromb Haemost. 2018;16:1078–88. https://doi. org/10.1111/jth.14022
19. Cohen J. A power primer. Psychol Bull. 1992;112:155–9.
20. Braun PJ, Givens TB, Stead AG, Beck LR, Gooch SA, Swan RJ, et al. Properties of optical data from activated partial thromboplastin time and prothrombin time assays. Thromb Haemost. 1997;78:1079–87. https://doi. org/10.1055/s-0038-1657690
21. Undas A, Zawilska K, Ciesla-Dul M, Lehmann-Kopydlowska A, Skubiszak A, Ciepluch K, et al. Altered fibrin clot structure/ function in patients with idiopathic venous thromboembolism and in their relatives. Blood. 2009;114:4272–8. https://doi.org/10.1182/blood-2009-05-222380
22. Cieslik J, Mrozinska S, Broniatowska E, Undas A. Altered plasma clot properties increase the risk of recurrent deep vein thrombosis: a cohort study. Blood. 2018;131:797–807. https://doi.org/10.1182/blood-2017-07-798306
23. Righini M, Robert-Ebadi H, Le Gal G. Diagnosis of acute pulmonary embolism. J Thromb Haemost. 2017;15:1251–61. https://doi.org/10.1111/jth.13694
24. Righini M, Perrier A, De Moerloose P, Bounameaux H. D-Dimer for venous thromboembolism diagnosis: 20 years later. J Thromb Haemost. 2008;6:1059–71. https://doi. org/10.1111/j.1538-7836.2008.02981.x
25. Brill-Edwards P, Lee A. D-dimer testing in the diagnosis of acute venous thromboembolism. Thromb Haemost. 1999;82:688–94. https://doi.org/10.1055/s-0037-1615898
26. Di Nisio M, Squizzato A, Rutjes AWS, Büller HR, Zwinder-man AH, Bossuyt PMM. Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review. J Thromb Haemost. 2007;5:296–304. https://doi. org/10.1111/j.1538-7836.2007.02328.x
27. Ng HJ, Lee LH. Trends in prevalence of deep venous thrombosis among hospitalised patients in an Asian institution. Thromb Haemost. 2009;101:1095–9. https://doi. org/10.1160/TH08-11-0755
28. Reddel CJ, Tan C, Chen V. Thrombin Generation and Cancer: Contributors and Consequences. Cancers (Basel). 2019;11:100. https://doi.org/10.3390/cancers11010100