An overview of positive cultures and clinical outcomes in septic patients: A sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial

Critical Care

Volumn 23, Issue 1, 2019, Pages

  Panday, Rishi S Nannan ^a,b   Lammers, Eline M J ^a   Alam, Nadia ^a   Nanayakkara, Prabath W B ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

(Blood) culture; (Multi) organ failure; Antibiotics; Antimicrobial therapy; Mortality; Organ dysfunction; Sepsis

Indexed keywords

ANTIBIOTIC AGENT; CEFTRIAXONE; ANTIINFECTIVE AGENT;

AGED; ANTIBIOTIC THERAPY; BACTERIUM CULTURE; BLOOD CULTURE; CLINICAL EVALUATION; CLINICAL FEATURE; CLINICAL OUTCOME; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; EMERGENCY CARE; FEMALE; GRAM NEGATIVE SEPSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; SEPSIS; CHI SQUARE DISTRIBUTION; COMPLICATION; EMERGENCY HEALTH SERVICE; MICROBIOLOGY; MIDDLE AGED; MORTALITY; NETHERLANDS; ORGAN DYSFUNCTION SCORE; PROCEDURES; SURVIVAL ANALYSIS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BLOOD CULTURE; CHI-SQUARE DISTRIBUTION; EMERGENCY MEDICAL SERVICES; FEMALE; HUMANS; MALE; MIDDLE AGED; MORTALITY; NETHERLANDS; ORGAN DYSFUNCTION SCORES; OUTCOME ASSESSMENT, HEALTH CARE; SEPSIS; SURVIVAL ANALYSIS;

EID: 85066474090     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-019-2431-8     Document Type: Review

References (31)

1. Deutschman CS, Tracey KJ. Sepsis: current dogma and new perspectives. Immunity. 2014;40(4):463-75.
2. Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med. 2016;193(3):259-72.
3. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303-10.
4. Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009;136(5):1237-48.
5. Bernard GR, Ely EW, Wright TJ, Fraiz J, Stasek JE Jr, Russell JA, et al. Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med. 2001;29(11):2051-9.
6. Gupta S, Sakhuja A, Kumar G, McGrath E, Nanchal RS, Kashani KB. Culture-negative severe sepsis: Nationwide trends and outcomes. Chest. 2016;150(6):1251-9.
7. Kethireddy S, Bilgili B, Sees A, Kirchner HL, Ofoma UR, Light RB, et al. Culture-negative septic shock compared with culture-positive septic shock: a retrospective cohort study. Crit Care Med. 2018;46(4):506-12.
8. Phua J, Ngerng W, See K, Tay C, Kiong T, Lim H, et al. Characteristics and outcomes of culture-negative versus culture-positive severe sepsis. Crit Care. 2013;17(5):R202.
9. Brooks D, Smith A, Young D, Fulton R, Booth MG. Mortality in intensive care: the impact of bacteremia and the utility of systemic inflammatory response syndrome. Am J Infect Control. 2016;44(11):1291-5.
10. Rannikko J, Syrjanen J, Seiskari T, Aittoniemi J, Huttunen R. Sepsis-related mortality in 497 cases with blood culture-positive sepsis in an emergency department. Int J Infect Dis. 2017;58:52-7.
11. Groenewoudt M, Roest AA, Leijten FM, Stassen PM. Septic patients arriving with emergency medical services: a seriously ill population. Eur J Emerg Med. 2014;21(5):330-5.
12. Alam N, Oskam E, Stassen PM, Exter PV, van de Ven PM, Haak HR, et al. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med. 2018;6(1):40-50.
13. Alam N, de Ven PM, Oskam E, Stassen P, Kramer MH, Exter PV, et al. Study protocol for a multi-centre, investigator-initiated, randomized controlled trial to compare the effects of prehospital antibiotic treatment for sepsis patients with usual care after training emergency medical services (EMS) personnel in early recognition (- the Prehospital ANTibiotics Against Sepsis (PHANTASi) trial. Acute Med 2016;15(4):176-184.
14. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801-10.
15. Baum GL. The significance of Candida albicans in human sputum. N Engl J Med. 1960;263:70-3.
16. Hall KK, Lyman JA. Updated review of blood culture contamination. Clin Microbiol Rev. 2006;19(4):788-802.
17. Robinson J. Colonization and infection of the respiratory tract: what do we know? Paediatr Child Health. 2004;9(1):21-4.
18. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31(4):1250-6.
19. Jager KJ, Zoccali C, Macleod A, Dekker FW. Confounding: what it is and how to deal with it. Kidney Int. 2008;73(3):256-60.
20. Coburn B, Morris AM, Tomlinson G, Detsky AS. Does this adult patient with suspected bacteremia require blood cultures? JAMA. 2012;308(5):502-11.
21. Fernando SM, Tran A, Taljaard M, Cheng W, Rochwerg B, Seely AJE, et al. Prognostic accuracy of the quick sequential organ failure assessment for mortality in patients with suspected infection: a systematic review and meta-analysis. Ann Intern Med. 2018;168(4):266-75.
22. Fernando SM, Rochwerg B, Seely AJE. Clinical implications of the third international consensus definitions for sepsis and septic shock (Sepsis-3). CMAJ. 2018;190(36):E1058-E9.
23. Levy MM, Dellinger RP, Townsend SR, Linde-Zwirble WT, Marshall JC, Bion J, et al. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010;36(2):222-31.
24. Bloos F, Hinder F, Becker K, Sachse S, Mekontso Dessap A, Straube E, et al. A multicenter trial to compare blood culture with polymerase chain reaction in severe human sepsis. Intensive Care Med. 2010;36(2):241-7.
25. Lehmann LE, Alvarez J, Hunfeld KP, Goglio A, Kost GJ, Louie RF, et al. Potential clinical utility of polymerase chain reaction in microbiological testing for sepsis. Crit Care Med. 2009;37(12):3085-90.
26. Suberviola B, Marquez-Lopez A, Castellanos-Ortega A, Fernandez-Mazarrasa C, Santibanez M, Martinez LM. Microbiological diagnosis of sepsis: polymerase chain reaction system versus blood cultures. Am J Crit Care. 2016;25(1):68-75.
27. Louie RF, Tang Z, Albertson TE, Cohen S, Tran NK, Kost GJ. Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia. Crit Care Med. 2008;36(5):1487-92.
28. Dark PM, Dean P, Warhurst G. Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection. Crit Care. 2009;13(4):217.
29. Venturelli C, Righi E, Borsari L, Aggazzotti G, Busani S, Mussini C, et al. Impact of pre-analytical time on the recovery of pathogens from blood cultures: results from a large retrospective survey. PLoS One. 2017;12(1):e0169466.
30. Bloos F, Reinhart K. Rapid diagnosis of sepsis. Virulence. 2014;5(1):154-60.
31. Sakr Y, Lobo SM, Moreno RP, Gerlach H, Ranieri VM, Michalopoulos A, et al. Patterns and early evolution of organ failure in the intensive care unit and their relation to outcome. Crit Care. 2012;16(6):R222.