Strong and Sustained Antihypertensive Effect of Small Interfering RNA Targeting Liver Angiotensinogen

Hypertension (Dallas, Tex. : 1979)

Volumn 73, Issue 6, 2019, Pages 1249-1257

  Uijl, Estrellita ^a   Mirabito Colafella, Katrina M ^a,b   Sun, Yuan ^a   Ren, Liwei ^a   van Veghel, Richard ^a   Garrelds, Ingrid M ^a   de Vries, René ^a   Poglitsch, Marko ^c   Zlatev, Ivan ^d   Kim, Jae B ^d   Hoorn, Ewout J ^a   Foster, Don ^d   Danser, A H Jan ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MONASH UNIVERSITY   (Australia)

^c Attoquant Diagnostics GmbH   (Austria)

^d Alnylam Pharmaceuticals

Author keywords

acute kidney injury; hypertension; hypertrophy, left ventricular; renin angiotensin system; RNA, small interfering; RNAi therapeutics

Indexed keywords

ANGIOTENSINOGEN; RNA; SMALL INTERFERING RNA;

ANIMAL; BIOSYNTHESIS; BLOOD PRESSURE; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HYPERTENSION; LIVER; MALE; METABOLISM; PHYSIOLOGY; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANGIOTENSINOGEN; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HYPERTENSION; INJECTIONS, SUBCUTANEOUS; LIVER; MALE; RATS; RATS, INBRED SHR; RNA; RNA, SMALL INTERFERING;

EID: 85065810615     PISSN: None     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.119.12703     Document Type: Article

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