Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell–Derived Endothelial Cells

Journal of the American College of Cardiology

Volumn 73, Issue 21, 2019, Pages 2722-2737

  Lee, Won Hee ^a,b   Ong, Sang Ging ^a,c   Zhou, Yang ^a   Tian, Lei ^a   Bae, Hye Ryeong ^a   Baker, Natalie ^a   Whitlatch, Adam ^d   Mohammadi, Leila ^d   Guo, Hongchao ^a   Nadeau, Kari C ^a   Springer, Matthew L ^d   Schick, Suzaynn F ^d   Bhatnagar, Aruni ^e   Wu, Joseph C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF ILLINOIS   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e University of Louisville School of Medicine   (United States)

Author keywords

e cigarette aerosol; e liquid flavoring; endothelial dysfunction; iPSC ECs

Indexed keywords

CASPASE 3; CASPASE 7; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; NICOTINE; REACTIVE OXYGEN METABOLITE; CYTOKINE;

APOPTOSIS; ARTICLE; CARDIOVASCULAR RISK; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; LEUKOCYTE COUNT; MACROPHAGE ACTIVATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RISK ASSESSMENT; ADULT; ADVERSE EVENT; BLOOD; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; DRUG EFFECT; ELECTRONIC CIGARETTE; MACROPHAGE; METABOLISM; SMOKING; VAPING;

ADULT; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CYTOKINES; ELECTRONIC NICOTINE DELIVERY SYSTEMS; ENDOTHELIAL CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LEUKOCYTE COUNT; MACROPHAGES; NICOTINE; REACTIVE OXYGEN SPECIES; SMOKERS; VAPING;

EID: 85065740078     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2019.03.476     Document Type: Article

References (29)

1. U.S. Department of Health and Human Services. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. 2014, U.S. Department of Health and Human Services, Atlanta, GA.
2. U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults: A Report of the Surgeon General. 2016, U.S. Department of Health and Human Services, Atlanta, GA.
3. Arrazola, R.A., Singh, T., Corey, C.G., et al. Tobacco use among middle and high school students - United States, 2011–2014. MMWR Morb Mortal Wkly Rep 64 (2015), 381–385.
4. Zhu, S.H., Sun, J.Y., Bonnevie, E., et al. Four hundred and sixty brands of e-cigarettes and counting: implications for product regulation. Tob Control 23:Suppl 3 (2014), iii3–iii9.
5. Scott, G., Proposed new steps to protect youth by preventing access to flavored tobacco products and banning menthol in cigarettes. FDA Statement, November 2018 Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/UCM625884.htm. (Accessed 9 April 2019)
6. Goniewicz, M.L., Knysak, J., Gawron, M., et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 23 (2014), 133–139.
7. Grana, R., Benowitz, N., Glantz, S.A., E-cigarettes: a scientific review. Circulation 129 (2014), 1972–1986.
8. Bahl, V., Lin, S., Xu, N., Davis, B., Wang, Y.H., Talbot, P., Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod Toxicol 34 (2012), 529–537.
9. Messner, B., Bernhard, D., Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis. Arterioscler Thromb Vasc Biol 34 (2014), 509–515.
10. Celermajer, D.S., Sorensen, K.E., Georgakopoulos, D., et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 88 (1993), 2149–2155.
11. Fetterman, J.L., Weisbrod, R.M., Feng, B., et al. Flavorings in tobacco products induce endothelial cell dysfunction. Arterioscler Thromb Vasc Biol 38 (2018), 1607–1615.
12. Kodo, K., Ong, S.G., Jahanbani, F., et al. iPSC-derived cardiomyocytes reveal abnormal TGF-beta signalling in left ventricular non-compaction cardiomyopathy. Nat Cell Biol 18 (2016), 1031–1042.
13. Coleman, B., Rostron, B., Johnson, S.E., et al. Transitions in electronic cigarette use among adults in the Population Assessment of Tobacco and Health (PATH) Study, Waves 1 and 2 (2013-2015). Tob Control 28 (2019), 50–59.
14. Delnevo, C.D., Giovenco, D.P., Steinberg, M.B., et al. Patterns of electronic cigarette use among adults in the United States. Nicotine Tob Res 18 (2016), 715–719.
15. Schnabel, R., Blankenberg, S., Oxidative stress in cardiovascular disease: successful translation from bench to bedside?. Circulation 116 (2007), 1338–1340.
16. Ghosh, A., Gao, L., Thakur, A., Siu, P.M., Lai, C.W.K., Role of free fatty acids in endothelial dysfunction. J Biomed Sci, 24, 2017, 50.
17. Kim, F., Tysseling, K.A., Rice, J., et al. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol 25 (2005), 989–994.
18. Behar, R.Z., Luo, W., Lin, S.C., et al. Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols. Tob Control 25 (2016), ii94–ii102.
19. Miller, M.A., Danhorn, T., Cruickshank-Quinn, C.I., et al. Gene and metabolite time-course response to cigarette smoking in mouse lung and plasma. PLoS One, 12, 2017, e0178281.
20. Haswell, L.E., Baxter, A., Banerjee, A., et al. Reduced biological effect of e-cigarette aerosol compared to cigarette smoke evaluated in vitro using normalized nicotine dose and RNA-seq-based toxicogenomics. Sci Rep, 7, 2017, 888.
21. Marsot, A., Simon, N., Nicotine and cotinine levels with electronic cigarette: a review. Int J Toxicol 35 (2016), 179–185.
22. Dawkins, L., Corcoran, O., Acute electronic cigarette use: nicotine delivery and subjective effects in regular users. Psychopharmacology (Berl) 231 (2014), 401–407.
23. Carnevale, R., Sciarretta, S., Violi, F., et al. Acute impact of tobacco vs electronic cigarette smoking on oxidative stress and vascular function. Chest 150 (2016), 606–612.
24. Nakamura, K., Barzi, F., Lam, T.H., et al. Cigarette smoking, systolic blood pressure, and cardiovascular diseases in the Asia-Pacific region. Stroke 39 (2008), 1694–1702.
25. Tan, H.Y., Wang, N., Li, S., Hong, M., Wang, X., Feng, Y., The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases. Oxid Med Cell Longev, 2016, 2016, 2795090.
26. He, C., Carter, A.B., The metabolic prospective and redox regulation of macrophage polarization. J Clin Cell Immunol, 6, 2015, 371.
27. Wannamethee, S.G., Lowe, G.D., Shaper, A.G., Rumley, A., Lennon, L., Whincup, P.H., Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease. Eur Heart J 26 (2005), 1765–1773.
28. Lymperaki, E., Makedou, K., Iliadis, S., Vagdatli, E., Effects of acute cigarette smoking on total blood count and markers of oxidative stress in active and passive smokers. Hippokratia 19 (2015), 293–297.
29. Nair, S., Kulkarni, S., Camoens, H.M., Ghosh, K., Mohanty, D., Changes in platelet glycoprotein receptors after smoking—a flow cytometric study. Platelets 12 (2001), 20–26.