Positive or Not, That Is the Question: HIV Testing for Individuals on Pre-exposure Prophylaxis

Journal of Acquired Immune Deficiency Syndromes

Volumn 78, Issue 2, 2018, Pages E11-E13

  Zucker, Jason ^a   Carnevale, Caroline ^b   Rai, Alex J ^a   Gordon, Peter ^a   Sobieszczyk, Magdalena E ^a  

^a NewYork Presbyterian Hospital   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOLUTEGRAVIR; EMTRICITABINE; TENOFOVIR; VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ADD ON THERAPY; ADULT; ANTIRETROVIRAL THERAPY; CASE REPORT; CLINICAL ARTICLE; COMBINATION DRUG THERAPY; CONDOM USE; DELAYED DIAGNOSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOASSAY; LETTER; LIMIT OF DETECTION; MALE; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PATIENT COMPLIANCE; POLYMERASE CHAIN REACTION; PRE-EXPOSURE PROPHYLAXIS; PRIORITY JOURNAL; REPEAT PROCEDURE; SEXUALITY; VIRUS DETECTION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; ISOLATION AND PURIFICATION; PROCEDURES;

ADULT; ANTI-HIV AGENTS; HIV; HIV INFECTIONS; HUMANS; MALE; PRE-EXPOSURE PROPHYLAXIS; RNA, VIRAL;

EID: 85065311942     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0000000000001665     Document Type: Letter

References (14)

1. Branson BM, Owen SM, Wesolowski LG, et al. Quick Reference Guide—Laboratory Testing for the Diagnosis of HIV Infection: Updated Recommendations Recommended Laboratory HIV Testing Algorithm for Serum or Plasma Specimens: Centers for Disease Control and Prevention and Association of Public Health Laboratories. 2014: 1–2. Available at: http://dx.doi.org/10.15620/cdc. 23447. Accessed August 24, 2017.
2. Fiebig E, Wright D, Rawal B, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003;17:1871–1879.
3. Busch MP, Satten GA. Time course of viremia and antibody seroconversion following human immunodeficiency virus exposure. Am J Med. 1997;102:117–124.
4. Curtis KA, Kennedy MS, Luckay A, et al. Delayed maturation of antibody avidity but not seroconversion in rhesus macaques infected with simian HIV during oral preexposure prophylaxis. J Acquir Immune Defic Syndr. 2011;57:355–362.
5. Sivay MV, Li M, Piwowar-Manning E, et al. Characterization of HIV seroconverters in a TDF/FTC PrEP study. J Acquir Immune Defic Syndr. 2017;75:1.
6. Donnell D, Ramos E, Celum C, et al. The effect of oral pre-exposure prophylaxis on the progression of HIV-1 seroconversion. AIDS. 2017;31:2007–2016.
7. Jensen TO, Robertson P, Whybin R, et al. A signal-to-cutoff ratio in the abbott architect HIV Ag/Ab combo assay that predicts subsequent confirmation of HIV-1 infection in a low-prevalence setting. J Clin Microbiol. 2015;53:1709–1711.
8. Ananworanich J, Chomont N, Eller LA, et al. HIV DNA set point is rapidly established in acute HIV infection and dramatically reduced by early ART. EBioMedicine. 2016;11:68–72.
9. De Souza MS, Pinyakorn S, Akapirat S, et al. Initiation of antiretroviral therapy during acute HIV-1 infection leads to a high rate of nonreactive HIV serology. Clin Infect Dis. 2016; 63:555–561.
10. Hoornenborg E, Prins M, Achterbergh RCA, et al. Acquisition of wild-type HIV-1 infection in a patient on pre-exposure prophylaxis with high intracellular concentrations of tenofovir diphosphate: a case report. Lancet HIV. 2017; 4:e522–e528.
11. Markowitz M, Grossman H, Anderson PL, et al. Newly acquired infection with multidrug resistant HIV-1 in a patient adherent to pre-exposure prophylaxis. J Acquir Immune Defic Syndr. 2017;76:e104–e106.
12. Anderson P, Harrigan PR, Tan D. Multidrugresistant HIV-1 infection despite preexposure prophylaxis. N Engl J Med. 2017;376:500–501.
13. Centers for Disease Control and Prevention. Preexposure prophylaxis for the prevention of HIV infection in the United States—2014 clinical practice guideline. 2014. Available at: http://www.cdc.gov/hiv/pdf/PrEPguidelines2014.pdf. Accessed July 24, 2016.
14. Association of Public Health Laboratories. Suggested reporting language for the diagnostic testing algorithm. 2017. Available at: https://www.aphl.org/aboutAPHL/publications/Documents/ID_2017Apr-HIVLab-Test-Suggested-Reporting-Language.pdf August 24, 2017.