Modern Adjuvants. functional aspects

Concepts in Vaccine Development

Volumn , Issue , 2012, Pages 243-264

  Morein, Bror ^a   Lövgren Bengtsson, Karin ^a   Cox, John ^a  

^a NATIONAL VETERINARY INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85064875785     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (85)

1. Adams, S. E, Dawson, K. M, Gull, K, Kingsman, S. M, and Kingsman, A. J. (1987) The expression of hybrid HIV: Ty virus-like particles in yeast. Nature 329, 68-70
2. Allison, A. C. and Byars, N. E. (1986) An Adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and cell-mediated immunity. J. Immunol. Methods 95, 157-168
3. Allison, A. C. and Byars, N. E. (1990) Adjuvant formulations and their mode of action. Semin Immunol. 2 (5), 369-374
4. Allison, A. C. and Byars, N. E. (1991) Immunological adjuvants: desirable properties and sideeffects. Mol. Immunol. 28(3), 279-284
5. Alving, C. R. (1992) Immunological aspects of liposomes: Presentation and processing of liposomal protein and phospholipid antigens. Biochim. Biophys. Acta 1113, 307-322
6. Asanuma, H., Koide, F., Suzuki, Y., Nagamine, T., Aizawa, C., Kurata, T., and Tamura, S. (1995) Cross-protection against influenza virus infection in mice vaccinated by combined nasal/subcutaneous administration. Vaccine 13, 3-5
7. Ben-Ahmeida, E. T. S, Potter, C. W, Gregoriadis, G., Adithan, C., and Jennings, R. (1994) IgG subclass response and protection against challenge following immunisation of mice with various influenza A vaccines.J Med Microbiol. 40, 261-269
8. Benner, R., Hijmans, W., and Haaijman, J. J. (1981b) The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation. Clin.Exp. Immunol. 46,1-8
9. Benner, R., van Oudenaren, A., and Koch, G. (1981a) Chapter 14. Induction of antibody formation in the mouse bone marrow. Immunol, methods II, 247-261
10. Bomford, R. (1980) The comparative selectivity of adjuvants for humoral and cell-mediated immunity, Effect on the antibody response to bovine serum albumin and sheep red blood cells of Freund's incomplete and complete adjuvants, alhydrogel, Corynebacterium parvum, Bordetella pertussis, muramyl dipeptide and saponin. Clin. Exp. Immunol. 39, 426-434
11. Böttiger, M. (1973) Experiences from investigations of virus isolations from sewage over a 2-year period with special regard to polioviruses. Arch. Gesamte Virusforschung 41, 80-85
12. Böttiger, M. (1984) Long-term immunity following vaccination with killed poliovirus vaccine in Sweden, a country with no circulating poliovirus. Rev. infect. Dis. 6, 548-551
13. Böttiger, M. and Herrström, E. (1992) Isolation of poliovirues from sewage and their characteristics: Experience over two decades in Sweden. Scand. J. Infect. Dis. 24, 151-155
14. Bright, H., Turnbull, T., Toms, G. L., and Scott, R. (1995) Comparison of the T helper cell response induced by respiratory syncytial virus and its fusion protein in BALB/c mice. Vaccine 13, 915-922
15. Ciaassen, I. J. T. M., Osterhaus, A. D. M. E., and Ciaassen, E. (1995) Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes. Eur. J. Immunology 25, 1446-1452
16. Ciaassen, I., Osterhaus, A., Boersma, W., Schellekens, M., and Ciaassen, E. (1995) Fluorescent labelling of virus, bacteria and iscoms: In vivo systemic and mucosal localisation patterns. In: Advances in Mucosal Immunology. Mestecky, J. et al. (eds). Plenum Press, New York, 1485-1489
17. Cox, J. and Coulter, A. (1992) Advances in adjuvant technology and application. In: Animal Parasite Control Utilizing Biotechnology. Yong, W. K. (ed.), CRC Press Boca Raton, Ann Arbor, London, Tokyo. 49-112
18. Cox, J. and Coulter, A. (1996) Adjuvants-structure and function. Submitted
19. Dalsgaard, K. (1974) Saponin adjuvants III Isolation of a substance from Quillaja saponaria molina with adjuvant activity in foot-and-mouth disease vaccines. Arch. ges. virus forsch. 44,243-254
20. Dalsgaard, K. (1978) A study on the isolation and characterization of the saponin Quii A. Evaluation of its adjuvant activity with special reference to the application in foot-and-mouth disease. Acta Vet. Scand. (suppl) 69,1-40
21. Dalsgaard, K., Jensen, M. H., and Sörensen, K. J. (1977) Saponin adjuvants IV. Evaluation of the adjuvant Quii A in the vaccination of cattle against foot-and-mouth disease. Acta vet. Scand. 18, 349-360
22. De Haan, A., Geerligs, H. J., Huchshorn, J. P., Van Scharrenburg, G. J. M., Palache, A. M., and Wilsschut, J. (1995) Mucosal immunoadjuvant activity of liposomes: induction of systemic IgG and secretory IgA responses in mice by intranasal immunization with an influenza subunit vaccine and coadministrated liposomes. Vaccine 13, 155-162
23. Deres, K., Schild, H., Wiesmuller, K. H., Jung, G., and Rammensee, H. G. (1989) In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature 342, 561-564
24. Dickinson, B. L. and Clements, J. D. (1995) Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity. Infect. Immun. 63, 1617-1623
25. Douce, G., Turcotte, C., Cropley, I., Roberts, M, Pizza, M., Domenghini, M., Rappuoli, R., and Dougan, G. (1995) Mutants of Escherichia coli heat-labile toxin lacking ADPribosyltransferase activity act as nontoxic, mucosal adjuvants. Proc. Natl. Acad. Sci. USA, 92, 1644-1648
26. Driscoll, J. (1994) The role of the proteasome in cellular protein degradation. Histol. Histophathol. 9, 197-202
27. Eldridge, J. H., Hammond, C. J., Meulbroek, J. A., Staas, J. K., Gilley, R. M., and Tice, T. R. (1990) Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches. J. controlled Rei. 11,205-214
28. Eldridge, J. H., Staas, J. K., Meulbroek, J. A., McGhee, J. A., Tice, T. R., and Gilley, R. M. (1991) Biodegradable microspheres as a vaccine delivery system. Mol. Immunol. 28, 287-294
29. Fontana, M. R., Manetti, R., Giannelli, V., Magagnoli, C., Marchini, A., Olivieri, R., Domenighini, M., Rappuoli, R., and Pizza, M. (1995) Construction of nontoxic derivatives of cholera toxin and characterization of the immunological response against the A subunit. Infect. Immun. 63, 2356-2360
30. Freund, J. (1951) The effect of paraffin oil and mycobacteria on antibody formation and sensitization. a review. Am. J. Clin. Pathol. 21, 645-656
31. Goldberg, A. L. and Rock, K. L. (1992) Proteolysis, proteasomes and antigen presentation. Nature, 357, 375-379
32. Gould-Fogerite, S., Edghill-Smith, Y., Kheiri, M., Wang, Z, Das, K., Feketeova, E, Canki, M., and Mannio, R. J. (1994) Lipid matrix-based subunit vaccines: A structure-function approach to oral and parenteral immunization. Aids Research and human retroviruses 10 suppl. 2, S99-S103
33. Hall, C. B. (1994) Prospects for a respiratory syncytial virus vaccine. Science 265,1393-1394
34. Hansen, D. S., Villacres-Eriksson, M., âkerblom, L., Hellman, U., Segura, E., Carlomagno, M., and Morein, B. (1996) An immunoaffinity purified Trypanosoma cruzi antigen suppresses cellular proliferation through a TGF-β mediated mechanism. Submitted
35. Harding, C. V., Collins, D. S., Slot, J. W., Geuze, H. J., and Unanue, E. R. (1991) Liposomeencapsulated antigens are processed in lysosomes, recycled, and presented to T cells. Cell 64, 393-401
36. Holt, L. B. (1949) Quantitative studies in diphtheria prophylaxis: the primary response. Br. J. Exp. Pathol. 30, 289-297
37. Howerton, D. A., Hunter, R. L., Ziegler, H. K., and Check, I. J. (1990) Induction of macrophage la expression in vivo by a synthetic block copolymer, L81. J. Immunol. 144, 1578-1584
38. Hu, J. G. and Kitagawa, T. (1990) Studies on the optimal immunization schedule of experimental animals. VI. Antigen dose-response of aluminium hydroxide-aided immunization and booster effect under low antigen dose. Chem. Pharm. Bull. 38, 2775-2779
39. Hunter, R. L., McNicholl, J., and Lai, A. (1994) Mechanism of action of nonionic block copolymer adjuvants. Aids Research and human retroviruses 10 suppl.2, S95-S98
40. Jones, P. D., Tha Hla, R., Morein, B., Lövgren, K., and Ada, G. L. (1988) Cellular immune responses in the murine lung to local immunization with influenza A virus glycoproteins in micelles and immunostimulatory complexes (iscoms). Scand. J. Immunol. 27, 645-652
41. Kersten, G. F. A. and Crommelin, D. J. A. (1995) Liposomes and iscoms as vaccine formulations. Biochim. Biophys Acta 1241, 117-138
42. Kraal, G., Janse, M., and Ciaassen, E. (1988) Marginal metallophilic macrophages in the mouse spleen: effects of neonatal injections of MOMA-1 antibody on the humoral immune response. Immunol. Lett. 17, 139-144
43. Labbe, M., Charpilienne, A., Crawford, S. E., Estes, M. K., and Cohen, J. (1991) Expression of rotavirus VP2 produces empty corelike particles. J. Virol. 65, 2946-2952
44. Lascelles, A. K., Eagleson, G., Beh, K. J., and Watson, D. L. (1989) Significance of Freund's adjuvant/antigen injection granuloma in the maintenance of serum antibody response. Vet. Immunol. Immunopathol. 22, 15-27
45. Lazorova, L., Artursson, P., Lövgren Bengtsson, K., and Sjölander, A. (1995) Influence of a particulate Quillaja saponin-containing adjuvant, iscom-matrix, on the handling and transport of influenza virus antigens in human intestinal epithelial cells (Caco-2). Submitted
46. Liew, F. Y., Russell, M., Appleyard, G., Brand, C. M., and Beale, J. (1984) Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity. Eur. J. Immunol. 14, 350-356
47. Lövgren, K., Kâberg, H., and Morein, B. (1990) An experimental influenza subunit vaccine (iscom): induction of protective immunity to challenge infection in mice after intranasal or subcutaneous administration. Clin. Exp. Immunol. 82, 435-439
48. Macatonia, S. E., Taylor, P. M., Knight, S. C., and Askonas, B. A. (1989) Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T-cell responses in vitro. J. Exp. Med. 169, 1255-1264
49. Mahon, B. P., Katrak, K, Nomoto, A., Macadam, A. J., Minor, P. D, and Mills, K. H. (1995) Poliovirus-specific CD4+ Thl clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. J. Exp. Med. 181, 1285-1292
50. Mannhalter, J. W, Neychev, H. O., Zlabinger, G. J., Ahmad, R., and Eibl, M. M. (1985) Modulation of the human immune response by the non-toxic and non-pyrogenic adjuvant aluminium hydroxide: effect on antigen uptake and antigen presentation. Clin. Exp. Immunol. 61, 141-151
51. McMenamin, C, Oliver, J., Girn, B, Holt, B. J., Kees, U. R., Thomas, W. R., and Holt, P. G. (1991) Regulation of T-cell sensitization at epithelial surfaces in the respiratory tract: suppression of IgE responses to inhaled antigens by CD3+ Ter alpha-/beta-lymphocytes (putative gamma/delta T cells). Immunology 74, 234-249
52. Morein, B., Lövgren, K., Rönnberg, B., Sjölander, A., Villacrés-Eriksson, M. (1995) Immunostimulating Complexes. Clinical Potential in Vaccine Development. Clinical Immunotherapeutics 3, 461-475. ADIS International
53. Morein, B., Sundquist, B., Höglund, S., Dalsgaard, K., and Osterhaus, A. (1984) Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature 308,457-460
54. Mowat, A. Mei. and Maloy, K. (1994) Chapter 3. Immune Stimulating Complexes as Vectors for Oral Immunization. In: Novel Delivery Systems for Oral Vaccines. O'Hagan, D. T. (ed.), CRC Press, Inc. Boca Raton, USA
55. Mumford, J. A., Jesset, D., Rollinson, E. A., Hannant, D., and Draper, M. E. (1994) Duration of protective efficacy of equine influenza immunostimulating complex/tetanus vaccines. The Veterinary Record, 12, 158-162
56. Neefjes, J., Gottfried, E., Roelse, J., Gromme, M., Obst, R., Hammerling, G. J., Momburg, F. (1995) Analyis of the fine specificity of rat, mouse and human TAP peptide transporters. Eur. J. Immunol. 25, 1133-1136
57. Nordengrahn, A., Merza, M., Rusvai, M., Ekström, J., Morein, B., and Belák, S. (1995) Equine Herpesvirus type 2 (EHV-2) as a predisposing factor for Rhodococcus equi pneumonia in foals: Prevention of the bifactorial disease with EHV-2 immunostimulating complexes. Submitted
58. O'Hagan, D. T., Palin, K. J., and Davis, S. S. (1989) Poly(butyl-2-cyanoacrylate) particles as adjuvants for oral immunization. Vaccine 7, 213-216
59. Osebold, J. W. (1982) Mechanisms of action by immunologic adjuvants. J. Vet. Med. Assoc. 181, 983-987
60. Ott, G., Barchfeld, G. L., Cheraoff, D., Radhakrishnan, R., van Hoogevest, P., and Van Nest, G. (1995) Design and evaluation of a safe and potent adjuvant for human vaccines. In: Vaccine design: The subunit and adjuvant approach. Powell, M. F. and Newman, M. J. (eds) Plenum Press, New York
61. Powell, M. F. and Newman, M. J. (eds) (1995) Vaccine Design: The subunit and adjuvant approach. Plenum Press, New York
62. Rechsteiner, M., Hoffmann, L., and Dubiel, W. (1993) The multicatylytic and 26S proteases. J. Biol. Chem. 268, 6065-6068
63. Ribi, E., Cantrell, J. L., Takayama, K., Qureshi, N., Peterson, J., and Ribi, H. O. (1984) Lipid A and immunotherapy. Rev. Infect. Dis. 6, 567-572
64. Rivett, J. (1993) Proteasomes: multicatylytic proteinase complexes. Biochem. J. 291, 1-10
65. Sacco, A. G., Yurewicz, E. C., and Subramanian, M. G. (1989) Effect of varying dosages and adjuvants on antibody response in squirrel monkeys (Saimirí sciureus) immunized with the porcine zona pellucida Mr = 55,000 glycoprotein (ZP3). Am. J. Reprod. Immunol. 21, 1-8
66. Santos, L. M., Lider, O., Audette, J., Khoury, S. J., and Weiner, H. L. (1990) Characterization of immunomodulatory properties and accessory cell function of small intestinal epithelial cells. Cell. Immunol. 127, 26-34
67. Scalzo, A. G., Elliot, S. L., Cox, J. C, Gardner, J., Moss, D. J., and Suhrbier, A. (1995) Induction of cytotoxic T cells to murine cytomegalovirus by using a nanopeptide and a humancompatible adjuvant (Montanide LSA-720). J. Virol. 69, 1306-1309
68. Sjölander, A., Lövgren Bengtsson, K., and Morein, B. (submitted) Kinetics, localization and cytokine profile of T cell responses to immune stimulating complexes (iscoms) containing human influenza virus envelope glycoproteins
69. Sjölander, A., Lövgren Bengtsson, K., Johansson, M., and Morein, B. (1996) Kinetics, localization and isotype profile of antibody responses to immune stimulating complexes (iscoms) containing human influenza virus envelope glycoproteins. Scand. J. Immunol., 43, 164-172
70. Snippe, H., De Reuver, M. J., Strickland, F., Willers, J. M. N., and Hunter, R.L. (1981) Adjuvant effect of nonionic block polymer surfactants in humoral and cellular immunity Int. Arch. Allergy Appi. Immunol. 65, 390-398
71. Snodgrass, D. R., Campbell, I., Mwenda, J. M., Chege, G., Seleman, M. A., Morein, B., and Hart, C. A. (1995) Stimulation of rotavirus IgA, IgG and neutralising antibodies in baboon milk by parenteral vaccination. Vaccine 13, 408-413
72. Staats, H. F., Jackson, R. J., Marinaro, M., Takahashi, I., Kiyono H, and McGhee, J. R. (1994) Mucosal immunity to infection with implications for vaccine development. Curr. Opin. Immunol. 6, 572-583
73. Strobbe, R., Charlier, G, Debecq, J., and van Aert, A. (1976) Studies about the adjuvant activity of saponin fractions in foot-and-mouth disease vaccine. III. Comparison of the irritant, adjuvant and hemolytic activities of six commercial saponins and their hemolytic fractions obtained by chromatography on Sephadex G100. Arch. Exp. Vet. Med. 30, 173-181
74. Svennerholm, A.-M., Hanson, L. A., Holmgren, I., Lindblad, B. S., Nilsson, B., and Quereshi, F. (1980) Different secretory immunoglobulin A antibody responses to cholera vaccination in Swedish and Pakistani women. Infect. Immun. 30,427-430
75. Takahashi, H., Takeshita, T., Morein, B., Putney, S., Germain, R. N., and Berzofsky, J. (1990) Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope proteins in iscoms. Nature 344, 873-875
76. Takayama, K., Olsen, M., Datta, P., and Hunter, R. L. (1991) Adjuvant activity of non-ionic block copolymers. V. Modulation of antibody isotype by lipopolysaccharides, lipid A and precursors. Vaccine 9, 257-265
77. Thepen, T., van Rooijen, N., and Kraal, G. (1989) Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice. J. exp. Med. 170, 499-509
78. Vajdy, M. and Lycke, N. (1993) Stimulation of antigen-specific T-and B-cell memory in local as well as systemic lymphoid tissues following oral immunization with cholera toxin adjuvant. Immunology 80, 197-203
79. Villacres-Eriksson, M. (1993) Induction of immune responses by iscoms. Ph. D. Thesis, Swedish University of Agricultural Sciences
80. Watson, D. L., Lövgren, K., Watson N. A., Fossum, C., Morein, B., and Höglund, S. (1989) The inflammatory response and antigen localization following immunization with influenza virus iscoms. Inflammation 13,641-649
81. Watson, D., Watson, N., Fossum, C., Lövgren, K., and Morein, B. (1992) Interactions between immune-stimulating complexes (ISCOMS) and peritoneal mononuclear leucocytes. Microbiol. and Immunol. 36, 199-203
82. Weiner, H. L., Friedman, A., Miller, A., Khoury, S. J., al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R. B.,Trentham, D. E., and Hafler, D. A. (1994) Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev.Immunol. 12, 809-837
83. Wilschut, J., De Haan, A., Geerligs, H. J., Huchschorn, J. P., van Schauenburg, G. J. M., Palache, A. M., Renegar, K. B., and Small Jr., P. A. (1994) Liposomes as a mucosal adjuvant system: An intranasal liposomal influenza subunit vaccine and the role of IgA in nasal anti-influenza immunity. J. Liposome Res. 4, 301
84. WO 90/14837. Adjuvant formulation comprising a submicron oil droplet emulsion, van Nest, G., Ott, G., Barchfield
85. WO 94/15636. Vaccine preparations. Cox, J., Sparks, R., Jacobs, I., Mason, N. Yap, K. L., Ada, G. L., and McKenzie, I. S. C. (1978) Transfer of specific cytotoxic T cells protects mice inoculated with influenza viruses. Nature 273, 238-239