Positive cumulative fluid balance is associated with mortality in pediatric acute respiratory distress syndrome in the setting of acute kidney injury

Pediatric Critical Care Medicine

Volumn 20, Issue 4, 2019, Pages 323-331

  Zinter, Matt S ^a   Spicer, Aaron C ^b   Liu, Kathleen D ^c   Orwoll, Benjamin E ^d   Alkhouli, Mustafa F ^a   Brakeman, Paul R ^e   Calfee, Carolyn S ^c   Matthay, Michael A ^c   Sapru, Anil ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acute kidney injury; Acute lung injury; Acute respiratory distress syndrome; Interleukin 6; Pediatric intensive care unit

Indexed keywords

CREATININE; INTERLEUKIN 6; BIOLOGICAL MARKER;

ACUTE KIDNEY FAILURE; ADULT RESPIRATORY DISTRESS SYNDROME; AGE; ARTICLE; CHILD; CHILD NUTRITION; CHILDHOOD CANCER; CREATININE BLOOD LEVEL; FEMALE; FLUID BALANCE; FLUID INTAKE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MORTALITY; OBSERVATIONAL STUDY; OLIGURIA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SURVIVOR; ADOLESCENT; ANCESTRY GROUP; ARTIFICIAL VENTILATION; BLOOD; ELECTROLYTE BALANCE; INFANT; PEDIATRIC INTENSIVE CARE UNIT; PHYSIOLOGY; PRESCHOOL CHILD; RISK FACTOR; SEVERITY OF ILLNESS INDEX; SEX FACTOR;

ACUTE KIDNEY INJURY; ADOLESCENT; AGE FACTORS; BIOMARKERS; CHILD; CHILD, PRESCHOOL; CONTINENTAL POPULATION GROUPS; FEMALE; HUMANS; INFANT; INTENSIVE CARE UNITS, PEDIATRIC; INTERLEUKIN-6; MALE; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; WATER-ELECTROLYTE BALANCE;

EID: 85064313259     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000001845     Document Type: Article

References (54)

1. Quasney MW, Lopez-Fernandez YM, Santschi M, et al: The outcomes of children with pediatric acute respiratory distress syndrome: Proceedings from the pediatric acute lung injury consensus conference. Pediatr Crit Care Med 2015; 16:S118–S131
2. Sapru A, Flori H, Quasney MW, et al; Pediatric Acute Lung Injury Consensus Conference Group: Pathobiology of acute respiratory distress syndrome. Pediatr Crit Care Med 2015; 16:S6–S22
3. Zinter MS, Orwoll BE, Spicer AC, et al: Incorporating inflammation into mortality risk in pediatric acute respiratory distress syndrome. Crit Care Med 2017; 45:858–866
4. Jozwiak M, Silva S, Persichini R, et al: Extravascular lung water is an independent prognostic factor in patients with acute respiratory distress syndrome. Crit Care Med 2013; 41:472–480
5. Kangelaris KN, Calfee CS, May AK, et al: Is there still a role for the lung injury score in the era of the Berlin definition ARDS? Ann Intensive Care 2014; 4:4
6. Jozwiak M, Teboul JL, Monnet X: Extravascular lung water in critical care: Recent advances and clinical applications. Ann Intensive Care 2015; 5:38
7. Zhao Z, Jiang L, Xi X, et al: Prognostic value of extravascular lung water assessed with lung ultrasound score by chest sonography in patients with acute respiratory distress syndrome. BMC Pulm Med 2015; 15:98
8. Sutherland SM, Zappitelli M, Alexander SR, et al: Fluid overload and mortality in children receiving continuous renal replacement therapy: The prospective pediatric continuous renal replacement therapy registry. Am J Kidney Dis 2010; 55:316–325
9. Flori HR, Church G, Liu KD, et al: Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract 2011; 2011:854142
10. Valentine SL, Sapru A, Higgerson RA, et al; Pediatric Acute Lung Injury and Sepsis Investigator’s (PALISI) Network; Acute Respiratory Distress Syndrome Clinical Research Network (ARDSNet): Fluid balance in critically ill children with acute lung injury. Crit Care Med 2012; 40:2883–2889
11. Arikan AA, Zappitelli M, Goldstein SL, et al: Fluid overload is associated with impaired oxygenation and morbidity in critically ill children. Pediatr Crit Care Med 2012; 13:253–258
12. Willson DF, Thomas NJ, Tamburro R, et al; Pediatric Acute Lung and Sepsis Investigators Network: The relationship of fluid administration to outcome in the pediatric calfactant in acute respiratory distress syndrome trial. Pediatr Crit Care Med 2013; 14:666–672
13. Alobaidi R, Morgan C, Basu RK, et al: Association between fluid balance and outcomes in critically ill children: A systematic review and meta-analysis. JAMA Pediatr 2018; 172:257–268
14. Wiedemann HP, Wheeler AP, Bernard GR, et al; National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network: Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006; 354:2564–2575
15. Díaz F, Nuñez MJ, Pino P, et al: Implementation of preemptive fluid strategy as a bundle to prevent fluid overload in children with acute respiratory distress syndrome and sepsis. BMC Pediatr 2018; 18:207
16. Goldstein SL, Devarajan P: Pediatrics: Acute kidney injury leads to pediatric patient mortality. Nat Rev Nephrol 2010; 6:393–394
17. Nechemia-Arbely Y, Barkan D, Pizov G, et al: IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol 2008; 19:1106–1115
18. Greenberg JH, Whitlock R, Zhang WR, et al; TRIBE-AKI Consortium: Interleukin-6 and interleukin-10 as acute kidney injury biomarkers in pediatric cardiac surgery. Pediatr Nephrol 2015; 30:1519–1527
19. Liu KD, Glidden DV, Eisner MD, et al; National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group: Predictive and patho-genetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med 2007; 35:2755–2761
20. Mikłaszewska M, Korohoda P, Zachwieja K, et al: Serum interleukin 6 levels as an early marker of acute kidney injury on children after cardiac surgery. Adv Clin Exp Med 2013; 22:377–386
21. Meduri GU, Headley S, Kohler G, et al: Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 1995; 107:1062–1073
22. Andres-Hernando A, Altmann C, Bhargava R, et al: Prolonged acute kidney injury exacerbates lung inflammation at 7 days post-acute kidney injury. Physiol Rep 2014; 2:e12084
23. Brower RG, Matthay MA, Morris A, et al; Acute Respiratory Distress Syndrome Network: Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342:1301–1308
24. Spicer AC, Calfee CS, Zinter MS, et al: A simple and robust bedside model for mortality risk in pediatric patients with acute respiratory distress syndrome. Pediatr Crit Care Med 2016; 17:907–916
25. Ranieri VM, Rubenfeld GD, Thompson BT, et al; ARDS Definition Task Force: Acute respiratory distress syndrome: The Berlin definition. JAMA 2012; 307:2526–2533
26. Schwartz GJ, Work DF: Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol 2009; 4:1832–1843
27. Akcan-Arikan A, Zappitelli M, Loftis LL, et al: Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 2007; 71:1028–1035
28. Zappitelli M, Parikh CR, Akcan-Arikan A, et al: Ascertainment and epidemiology of acute kidney injury varies with definition interpretation. Clin J Am Soc Nephrol 2008; 3:948–954
29. Wells JC, Fewtrell MS, Davies PS, et al: Prediction of total body water in infants and children. Arch Dis Child 2005; 90:965–971
30. Liu KD, Thompson BT, Ancukiewicz M, et al; National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network: Acute kidney injury in patients with acute lung injury: Impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med 2011; 39:2665–2671
31. Pollack MM, Patel KM, Ruttimann UE: PRISM III: An updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24:743–752
32. Imai K, Keele L, Tingley D: A general approach to causal mediation analysis. Psychol Methods 2010; 15:309–334
33. Soler YA, Nieves-Plaza M, Prieto M, et al: Pediatric risk, injury, failure, loss, end-stage renal disease score identifies acute kidney injury and predicts mortality in critically ill children: A prospective study. Pediatr Crit Care Med 2013; 14:e189–e195
34. Chen J, Li X, Bai Z, et al: Association of fluid accumulation with clinical outcomes in critically ill children with severe sepsis. PLoS One 2016; 11:e0160093
35. Sakr Y, Vincent JL, Reinhart K, et al; Sepsis Occurence in Acutely Ill Patients Investigators: High tidal volume and positive fluid balance are associated with worse outcome in acute lung injury. Chest 2005; 128:3098–3108
36. Lucas CE, Ledgerwood AM, Shier MR, et al: The renal factor in the post-traumatic “fluid overload” syndrome. J Trauma 1977; 17:667–676
37. Lowenstein J, Schacht RG, Baldwin DS: Renal failure in minimal change nephrotic syndrome. Am J Med 1981; 70:227–233
38. Kuebler WM, Ying X, Singh B, et al: Pressure is proinflammatory in lung venular capillaries. J Clin Invest 1999; 104:495–502
39. Bruegger D, Jacob M, Rehm M, et al: Atrial natriuretic peptide induces shedding of endothelial glycocalyx in coronary vascular bed of guinea pig hearts. Am J Physiol Heart Circ Physiol 2005; 289:H1993–H1999
40. Chappell D, Bruegger D, Potzel J, et al: Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx. Crit Care 2014; 18:538
41. Semler MW, Marney AM, Rice TW, et al; NIH NHLBI ARDS Network: B-type natriuretic peptide, aldosterone, and fluid management in ARDS. Chest 2016; 150:102–111
42. Plötz FB, Bouma AB, van Wijk JA, et al: Pediatric acute kidney injury in the ICU: An independent evaluation of pRIFLE criteria. Intensive Care Med 2008; 34:1713–1717
43. Bresolin N, Bianchini AP, Haas CA: Pediatric acute kidney injury assessed by pRIFLE as a prognostic factor in the intensive care unit. Pediatr Nephrol 2013; 28:485–492
44. Sutherland SM, Byrnes JJ, Kothari M, et al: AKI in hospitalized children: Comparing the pRIFLE, AKIN, and KDIGO definitions. Clin J Am Soc Nephrol 2015; 10:554–561
45. Cordemans C, De Laet I, Van Regenmortel N, et al: Aiming for a negative fluid balance in patients with acute lung injury and increased intra-abdominal pressure: A pilot study looking at the effects of PAL-treatment. Ann Intensive Care 2012; 2(Suppl 1):S15
46. Goldstein SL, Currier H, Graf Cd, et al: Outcome in children receiving continuous venovenous hemofiltration. Pediatrics 2001; 107:1309–1312
47. Foland JA, Fortenberry JD, Warshaw BL, et al: Fluid overload before continuous hemofiltration and survival in critically ill children: A retrospective analysis. Crit Care Med 2004; 32:1771–1776
48. Hayes LW, Oster RA, Tofil NM, et al: Outcomes of critically ill children requiring continuous renal replacement therapy. J Crit Care 2009; 24:394–400
49. Famous KR, Delucchi K, Ware LB, et al; ARDS Network: Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care Med 2017; 195:331–338
50. Calfee CS, Delucchi K, Parsons PE, et al; NHLBI ARDS Network: Subphenotypes in acute respiratory distress syndrome: Latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2014; 2:611–620
51. Duncan CN, Lehmann LE, Cheifetz IM, et al; Pediatric Acute Lung Injury and Sepsis (PALISI) Network: Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant. Pediatr Crit Care Med 2013; 14:261–267
52. Zinter MS, DuBois SG, Spicer A, et al: Pediatric cancer type predicts infection rate, need for critical care intervention, and mortality in the pediatric intensive care unit. Intensive Care Med 2014; 40:1536–1544
53. Michael M, Kuehnle I, Goldstein SL: Fluid overload and acute renal failure in pediatric stem cell transplant patients. Pediatr Nephrol 2004; 19:91–95
54. Harambat J, van Stralen KJ, Kim JJ, et al: Epidemiology of chronic kidney disease in children. Pediatr Nephrol 2012; 27:363–373