Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus

JCI insight

Volumn 3, Issue 23, 2018, Pages

  Liu, Yudong ^a   Lightfoot, Yaíma L ^a   Seto, Nickie ^a   Carmona Rivera, Carmelo ^a   Moore, Erica ^a   Goel, Rishi ^a   O'Neil, Liam ^a   Mistry, Pragnesh ^a   Hoffmann, Victoria ^b   Mondal, Santanu ^c   Premnath, Padmavathy Nandha ^c   Gribbons, Katherine ^a   Dell'Orso, Stefania ^d   Jiang, Kan ^d   Thompson, Paul R ^c   Sun, Hong Wei ^d   Coonrod, Scott A ^e   Kaplan, Mariana J ^a  

^a NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^b Office of the Director   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d IRP   (United States)

^e Animal Health Diagnostic Center   (United States)

Author keywords

Autoimmune diseases; Autoimmunity; Inflammation; Lupus; Neutrophils

Indexed keywords

HISTONE; HYDROLASE; INTERFERON; PADI2 PROTEIN, MOUSE; PEPTIDYLARGININE DEIMINASE 4, MOUSE; PROTEIN ARGININE DEIMINASE; TOLL LIKE RECEPTOR 7; TRANSCRIPTOME;

ADAPTIVE IMMUNITY; ANIMAL; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; DISEASE MODEL; EXTRACELLULAR TRAP; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; INNATE IMMUNITY; KNOCKOUT MOUSE; METABOLISM; MOUSE; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; TH1 CELL; TH17 CELL;

ADAPTIVE IMMUNITY; ANIMALS; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; EXTRACELLULAR TRAPS; FEMALE; GENE EXPRESSION REGULATION; HISTONES; HUMANS; HYDROLASES; IMMUNITY, INNATE; INFLAMMATION; INTERFERON TYPE I; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, KNOCKOUT; PROTEIN-ARGININE DEIMINASES; T-LYMPHOCYTES; TH1 CELLS; TH17 CELLS; TOLL-LIKE RECEPTOR 7; TRANSCRIPTOME;

EID: 85063240542     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.124729     Document Type: Article

References (0)