Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

JCI insight

Volumn 4, Issue 4, 2019, Pages

  Liu, Li ^a,b   Wei, Qiang ^c   Lin, Qingqing ^a   Fang, Jun ^a   Wang, Haibo ^a   Kwok, Hauyee ^a   Tang, Hangying ^a   Nishiura, Kenji ^a   Peng, Jie ^a   Tan, Zhiwu ^a   Wu, Tongjin ^a   Cheung, Ka Wai ^a   Chan, Kwok Hung ^a   Alvarez, Xavier ^d   Qin, Chuan ^c   Lackner, Andrew ^d   Perlman, Stanley ^e,f   Yuen, Kwok Yung ^a   Chen, Zhiwei ^a,b  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b SHENZHEN THIRD PEOPLE S HOSPITAL   (China)

^c INSTITUTE OF LABORATORY ANIMAL SCIENCE   (China)

^d TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cytokines; Immunoglobulins; Infectious disease; Macrophages; Pulmonology

Indexed keywords

CORONAVIRUS SPIKE GLYCOPROTEIN; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY; VIRUS VACCINE;

ACUTE LUNG INJURY; ADULT; AGED; ANIMAL; BLOOD; CELL LINE; DISEASE MODEL; FEMALE; GENETICS; HUMAN; IMMUNOLOGY; LUNG; LUNG ALVEOLUS MACROPHAGE; MALE; METABOLISM; MIDDLE AGED; PASSIVE IMMUNIZATION; PATHOGENICITY; PATHOLOGY; PROCEDURES; RHESUS MONKEY; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VACCINIA VIRUS; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ACUTE LUNG INJURY; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL LINE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; LUNG; MACACA MULATTA; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SPIKE GLYCOPROTEIN, CORONAVIRUS; VACCINIA VIRUS; VIRAL VACCINES; YOUNG ADULT;

EID: 85062393219     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.123158     Document Type: Article

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