The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense

JCI insight

Volumn 4, Issue 4, 2019, Pages

  Horton, Julie L ^a   Davidson, Michael T ^b   Kurishima, Clara ^c   Vega, Rick B ^a   Powers, Jeffery C ^c   Matsuura, Timothy R ^d   Petucci, Christopher ^a,d   Lewandowski, E Douglas ^a,e   Crawford, Peter A ^a,f   Muoio, Deborah M ^b   Recchia, Fabio A ^c,g   Kelly, Daniel P ^a,d  

^a BURNHAM INSTITUTE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g SCUOLA SUPERIORE SANT ANNA   (Italy)

Author keywords

Cardiology; Heart failure; Metabolism; Mitochondria; Mouse models

Indexed keywords

3 HYDROXYBUTYRIC ACID; HYDROXYBUTYRATE DEHYDROGENASE;

ANIMAL; CARDIAC MUSCLE; CYTOLOGY; DISEASE EXACERBATION; DISEASE MODEL; DOG; ENERGY METABOLISM; FEMALE; GENETICS; HEART FAILURE; HEART VENTRICLE; HEART VENTRICLE REMODELING; HUMAN; ISOLATED HEART; KNOCKOUT MOUSE; MALE; METABOLISM; MITOCHONDRION; MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGICAL STRESS; THERMODYNAMICS;

3-HYDROXYBUTYRIC ACID; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DOGS; ENERGY METABOLISM; FEMALE; HEART FAILURE; HEART VENTRICLES; HUMANS; HYDROXYBUTYRATE DEHYDROGENASE; ISOLATED HEART PREPARATION; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MYOCARDIUM; OXIDATION-REDUCTION; STRESS, PHYSIOLOGICAL; THERMODYNAMICS; VENTRICULAR REMODELING;

EID: 85062062876     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.124079     Document Type: Article

References (0)