Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

JCI insight

Volumn 3, Issue 1, 2018, Pages

  Guedan, Sonia ^a   Posey, Avery D ^a   Shaw, Carolyn ^a   Wing, Anna ^a   Da, Tong ^a   Patel, Prachi R ^a   McGettigan, Shannon E ^a   Casado Medrano, Victoria ^a   Kawalekar, Omkar U ^a   Uribe Herranz, Mireia ^b   Song, Decheng ^a   Melenhorst, J Joseph ^a   Lacey, Simon F ^a   Scholler, John ^a   Keith, Brian ^a   Young, Regina M ^a   June, Carl H ^a  

^a Department of Pathology and Laboratory Medicine ^*

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Immunology; Immunotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CD137 LIGAND; CD28 ANTIGEN; INDUCIBLE T CELL COSTIMULATOR;

ADENOCARCINOMA; ANIMAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MEMBRANE; DRUG SCREENING; HUMAN; IMMUNOLOGY; LUNG TUMOR; METABOLISM; METASTASIS; MOUSE; PANCREAS TUMOR; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR CELL LINE;

4-1BB LIGAND; ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; CD28 ANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL MEMBRANE; HUMANS; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; LUNG NEOPLASMS; MICE; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS; RECEPTORS, CHIMERIC ANTIGEN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85062013005     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.96976     Document Type: Article

References (0)